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Dive into the research topics where Donald Hnatowich is active.

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Featured researches published by Donald Hnatowich.


Molecular Imaging and Biology | 2006

Influence of Two Transfectors on Delivery of 99mTc Antisense DNA in Tumor-Bearing Mice

Kayoko Nakamura; Yi Wang; Xinrong Liu; Atsushi Kubo; Donald Hnatowich

PurposeThe aim of the study is to determine whether delivery into tumor cells in vivo of a 99mTc-labeled antisense phosphorothioate DNA targeting the mdr1 mRNA improves after electrostatic complexation with the transmembrane transfector (TF) carriers Neophectin™ or jetPEI™ as was observed by us in vitro.MethodsThe biodistribution of the labeled antisense DNA before and after complexation with either TF was determined in nude mice bearing KB-G2 (Pgp++) tumors.ResultsComplexation with either TF resulted in significantly higher background radioactivity levels in almost all normal tissues and modest improvement in tumor accumulation at best. The tumor accumulation was lower compared to naked at six hours (0.34 and 0.23 vs. 0.40% ID/g) and modestly higher at 24–28 hours (0.15 and 0.15 vs. 0.12% ID/g) for Neophectin and jetPEI, respectively. That blood was less than 0.18% ID/g for both TFs even at six hours suggests that tumor accumulations may have suffered from rapid blood clearance.ConclusionThe results of this investigation show that because of the unfavorable pharmacokinetics of radiolabeled phosphorothioate DNAs when electrostatically complexed to jetPEI or Neophectin, neither TF appears to be useful in vivo despite favorable results in vitro. Future studies will devote greater consideration to the relative rates of tumor accumulation and blood clearance.


Bioconjugate Chemistry | 2004

Evidence of antisense tumor targeting in mice

Kayoko Nakamura; Fan C; Guozheng Liu; Jiang He; Shuping Dou; Atsushi Kubo; Mary Rusckowski; Donald Hnatowich


Society of Nuclear Medicine Annual Meeting Abstracts | 2008

Evaluation of a new TAG-72 binding peptide

Ling Chen; Yi Wang; Xinrong Liu; Guozheng Liu; Shuping Dou; Nan Xiao; Donald Hnatowich; Mary Rusckowski


Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Imaging Candida albicans infection in mice by targeting ribosomal RNA

Yuzhen Wang; Ling Chen; Xinrong Liu; Guozheng Liu; Shuping Dou; Donald Hnatowich; Mary Rusckowski


Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Intraperitoneal administration is not always a viable alternative to intravenous administration

Guozheng Liu; Shuping Dou; Miles Smith; Yuzhen Wang; Mary Rusckowski; Donald Hnatowich


Society of Nuclear Medicine Annual Meeting Abstracts | 2011

Pretargeting vs direct targeting of a human islet cell transplant in mice

Guozheng Liu; Shuping Dou; Mary Rusckowski; Philip R. Streeter; Dale Greiner; Donald Hnatowich


Society of Nuclear Medicine Annual Meeting Abstracts | 2011

90Y labeled cMORF for pretargeting radiotherapy in mice

Guozheng Liu; Shuping Dou; Yuxia Liu; Yuzhen Wang; Mary Rusckowski; Donald Hnatowich


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Evaluation of two TAG-72 binding peptides identified by phage display selection

Ling Chen; Dengfeng Cheng; Yi Wang; Guozheng Liu; Shuping Dou; Xinrong Liu; Donald Hnatowich; Mary Rusckowski


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Modifying the biodistribution of the anti TAG-72 peptide T3-15 peptide by multivalent PEG conjugation

Nan Xiao; Xinrong Liu; Dengfeng Cheng; Yuxia Liu; Guozheng Liu; Ling Chen; Minmin Liang; Donald Hnatowich; Mary Rusckowski


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Nanoparticle-mediated anti-Her2/neu siRNA delivery for breast cancer therapy in vitro

Xinrong Liu; Kayoko Nakamura; Dengfeng Cheng; Minmin Liang; Yuxia Liu; Ling Chen; Mary Rusckowski; Donald Hnatowich

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Mary Rusckowski

University of Massachusetts Amherst

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Xinrong Liu

University of Massachusetts Medical School

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Guozheng Liu

University of Massachusetts Amherst

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Ling Chen

University of Massachusetts Medical School

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Shuping Dou

University of Massachusetts Medical School

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Minmin Liang

University of Massachusetts Medical School

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Yuxia Liu

University of Massachusetts Medical School

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