Donald L. Schneider

Effect of Cholestyramine on Cholesterol Metabolism in Young Adult Swine

Summary Nine-week-old swine were fed the bile acid sequestrant, cholestyramine, at 2% and 4% of the diet for successive 4-week periods. Cholestyramine increased bile acid excretion about 10-fold, but the rate of liver biosynthesis of cholesterol was 19 times higher in the cholestyramine fed pigs than in the control pigs. This marked increase in cholesterol synthesis was apparently sufficient to prevent a decrease in plasma cholesterol levels. Feeding 4% cholestyramine (approximately 70 g/day) had no effect on growth, food efficiency, organ weights, plasma lipids and aorta cholesterol. Liver cholesterol levels were decreased slightly, liver vitamin A stores were decreased about one-third, and excretion of fecal fat and cholesterol-like (Lieberman-Burchard reactive) materials were increased in the cholestyramine fed pigs.

Effect of Sterculia foetida oil on uptake of water by the avian egg yolk.

Summary The yolks of eggs from hens having a one-egg clutch average took up significantly more water than those from hens having 2-4 egg clutch sizes. Yolks from hens having 2, 3, and 4 egg clutch, sizes showed no significant differences in water uptake. Yolks from eggs stored overnight and from hens given Sterculia foetida oil were not significantly heavier and did not take up more water than eggs from hens given corn oil. However, when the eggs were stored one month the yolks from the hens fed Sterculia foetida oil increased 20% in weight and showed an 80% greater water uptake than those from the corn oil fed hens.