Dong-Gi Kwag

The Study on the Market Competitiveness Reinforcement for Convergence Industry

The purpose of this research is to bring supportive ways to reinforce the market competitiveness of fusion industry based on the rapidly arising fusion industries considering system improvement and fusion R&D support. The research has proceeded in the order of setup for competitiveness reinforcing way of fusion industry and deduction for competitiveness reinforcing way based on directivity. It classified the fusion industry into introduction, diffusion and development by time, and suggested expert fusion R&D, open type fusion R&D, customized fusion R&D, system improvement of market entrance and supportive way for public purchase as the supportive way. It`s purpose is to lead the entrance into the new fusion market, stabilize to settle into the market and create high value products by resolving difficulties for the market entrance of the new fusion products & service, reinforcing the fusion capability and securing the competitive advantage.

Enhancement of skin permeation of vitamin C using vibrating microneedles

This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC0-∞ and Cmax increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.