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Dive into the research topics where Dong-Guk Paeng is active.

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Featured researches published by Dong-Guk Paeng.


Ultrasound in Medicine and Biology | 2010

Cyclic and radial variation of the echogenicity of blood in human carotid arteries observed by harmonic imaging.

Dong-Guk Paeng; Kweon-Ho Nam; K. Kirk Shung

To better understand the characteristics of erythrocyte aggregation in flowing blood, echogenicity variation in blood was observed both in vitro and in vivo. However, few noninvasive observations of blood echogenicity variation during the cardiac cycle in human arteries have been reported. In the present study, to reduce the dynamic range between the blood vessel lumen and the surrounding tissue, coded harmonic images were acquired from human carotid arteries using a GE LOGIQ 700 Expert system (GE, Milwaukee, WI, USA) with an M12L probe, which enabled the noninvasive detection of the cyclic and radial variation of echogenicity in arterial vessels. It was found that blood echogenicity increased during systole, reaching a maximum at peak systole and then decreased to a weak level during diastole. The echogenicity profiles of blood along the vessel diameter were found to be approximately parabolic in the cardiac cycle, except for the hypoechoic zone near the center of the vessel at peak systole. The present results for human carotid arteries corroborate previous in vitro observations that showed a cyclic and radial variation of blood echogenicity, which was thought to be caused by the enhancement of erythrocyte aggregation due to the combined effects of flow acceleration and shear rate during systole.


Ultrasonics | 2014

Improvement of ultrasound speckle image velocimetry using image enhancement techniques

Eunseop Yeom; Kweon-Ho Nam; Dong-Guk Paeng; Sang Joon Lee

Ultrasound-based techniques have been developed and widely used in noninvasive measurement of blood velocity. Speckle image velocimetry (SIV), which applies a cross-correlation algorithm to consecutive B-mode images of blood flow has often been employed owing to its better spatial resolution compared with conventional Doppler-based measurement techniques. The SIV technique utilizes speckles backscattered from red blood cell (RBC) aggregates as flow tracers. Hence, the intensity and size of such speckles are highly dependent on hemodynamic conditions. The grayscale intensity of speckle images varies along the radial direction of blood vessels because of the shear rate dependence of RBC aggregation. This inhomogeneous distribution of echo speckles decreases the signal-to-noise ratio (SNR) of a cross-correlation analysis and produces spurious results. In the present study, image-enhancement techniques such as contrast-limited adaptive histogram equalization (CLAHE), min/max technique, and subtraction of background image (SB) method were applied to speckle images to achieve a more accurate SIV measurement. A mechanical sector ultrasound scanner was used to obtain ultrasound speckle images from rat blood under steady and pulsatile flows. The effects of the image-enhancement techniques on SIV analysis were evaluated by comparing image intensities, velocities, and cross-correlation maps. The velocity profiles and wall shear rate (WSR) obtained from RBC suspension images were compared with the analytical solution for validation. In addition, the image-enhancement techniques were applied to in vivo measurement of blood flow in human vein. The experimental results of both in vitro and in vivo SIV measurements show that the intensity gradient in heterogeneous speckles has substantial influence on the cross-correlation analysis. The image-enhancement techniques used in this study can minimize errors encountered in ultrasound SIV measurement in which RBCs are used as flow tracers instead of exogenous contrast agents.


Ultrasound in Medicine and Biology | 2013

TEMPERATURE-DEPENDENT THERMAL PROPERTIES OF EX VIVO LIVER UNDERGOING THERMAL ABLATION

Sitaramanjaneya Reddy Guntur; Kang Il Lee; Dong-Guk Paeng; Andrew Coleman; Min Joo Choi

Thermotherapy uses a heat source that raises temperatures in the target tissue, and the temperature rise depends on the thermal properties of the tissue. Little is known about the temperature-dependent thermal properties of tissue, which prevents us from accurately predicting the temperature distribution of the target tissue undergoing thermotherapy. The present study reports the key thermal parameters (specific heat capacity, thermal conductivity and heat diffusivity) measured in ex vivo porcine liver while being heated from 20 ° C to 90 ° C and then naturally cooled down to 20 ° C. The study indicates that as the tissue was heated, all the thermal parameters resulted in plots with asymmetric quasi-parabolic curves with temperature, being convex downward with their minima at the turning temperature of 35-40 ° C. The largest change was observed for thermal conductivity, which decreased by 9.6% from its initial value (at 20 ° C) at the turning temperature (35 ° C) and rose by 45% at 90 ° C from its minimum (at 35 ° C). The minima were 3.567 mJ/(m(3) ∙ K) for specific heat capacity, 0.520 W/(m.K) for thermal conductivity and 0.141 mm(2)/s for thermal diffusivity. The minimum at the turning temperature was unique, and it is suggested that it be taken as a characteristic value of the thermal parameter of the tissue. On the other hand, the thermal parameters were insensitive to temperature and remained almost unchanged when the tissue cooled down, indicating that their variations with temperature were irreversible. The rate of the irreversible rise at 35 ° C was 18% in specific heat capacity, 40% in thermal conductivity and 38.3% in thermal diffusivity. The study indicates that the key thermal parameters of ex vivo porcine liver vary largely with temperature when heated, as described by asymmetric quasi-parabolic curves of the thermal parameters with temperature, and therefore, substantial influence on the temperature distribution of the tissue undergoing thermotherapy is expected.


Ultrasonics | 2014

3D reconstruction of a carotid bifurcation from 2D transversal ultrasound images.

Eunseop Yeom; Kweon-Ho Nam; Changzhu Jin; Dong-Guk Paeng; Sang Joon Lee

Visualizing and analyzing the morphological structure of carotid bifurcations are important for understanding the etiology of carotid atherosclerosis, which is a major cause of stroke and transient ischemic attack. For delineation of vasculatures in the carotid artery, ultrasound examinations have been widely employed because of a noninvasive procedure without ionizing radiation. However, conventional 2D ultrasound imaging has technical limitations in observing the complicated 3D shapes and asymmetric vasodilation of bifurcations. This study aims to propose image-processing techniques for better 3D reconstruction of a carotid bifurcation in a rat by using 2D cross-sectional ultrasound images. A high-resolution ultrasound imaging system with a probe centered at 40MHz was employed to obtain 2D transversal images. The lumen boundaries in each transverse ultrasound image were detected by using three different techniques; an ellipse-fitting, a correlation mapping to visualize the decorrelation of blood flow, and the ellipse-fitting on the correlation map. When the results are compared, the third technique provides relatively good boundary extraction. The incomplete boundaries of arterial lumen caused by acoustic artifacts are somewhat resolved by adopting the correlation mapping and the distortion in the boundary detection near the bifurcation apex was largely reduced by using the ellipse-fitting technique. The 3D lumen geometry of a carotid artery was obtained by volumetric rendering of several 2D slices. For the 3D vasodilatation of the carotid bifurcation, lumen geometries at the contraction and expansion states were simultaneously depicted at various view angles. The present 3D reconstruction methods would be useful for efficient extraction and construction of the 3D lumen geometries of carotid bifurcations from 2D ultrasound images.


IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control | 2009

Ultrasonic backscatter from rat blood in aggregating media under in vitro rotational flow

Kweon-Ho Nam; Dong-Guk Paeng; Min Joo Choi

Ultrasonic backscatter from flowing and static rat red blood cells (RBCs) in autologous plasma and in 360 kDa polyvinylpyrrolidone (PVP 360) solution was measured as a function of hematocrit. The flow speed was varied by a stirring magnet in a cylindrical chamber. The radio-frequency (RF) signals backscattered by RBC samples were measured over 5 min in a pulse-echo setup with a 5 MHz focused transducer. Although the intact rat blood has poor RBC aggregability, RBC aggregation of rat blood was enhanced by replacing its plasma with a higher molecular weight polymer solution. The experimental results showed that the nonlinear relationship between hematocrit and ultrasonic backscatter from rat RBCs in plasma and aggregating media is affected by flow speed, which may provide a unified insight into hematocrit dependence of RBC aggregation under flowing and static conditions.


IEEE Transactions on Biomedical Engineering | 2010

Reusable Ultrasonic Tissue Mimicking Hydrogels Containing Nonionic Surface-Active Agents for Visualizing Thermal Lesions

Seong Keun Park; S.R.Anjaneya Reddy Guntur; Kang Il Lee; Dong-Guk Paeng; Min Joo Choi

The present study aims to identify a new recipe for reusable tissue mimicking phantoms that allows the optical visualization of thermal lesions produced in various applications of therapeutic ultrasound where thermal mechanisms are important. The phantom was made of polyacrylamide hydrogel containing a nonionic surface-active agent (NiSAA) as a temperature-sensitive indicator. Threshold temperature above which a thermal lesion is regarded to be formed in the phantom is controlled by selecting an NiSAA. In the present study, three NiSAAs of polyoxyethylene alkyl ether series with nominal clouding points of 66°C, 70°C, and 80°C were chosen. Test phantoms were prepared with polyacrylamide hydrogel, corn syrup and NiSAAs [5% (w/v)]. Key acoustic properties of the three NiSAA hydrogels were found to be similar to those of human liver. The phantoms were optically transparent at room temperature (25°C) and became opaque after exceeding the clouding points. The transparency was recovered on cooling, although the system demonstrated hysteresis. The phantoms were tested both in their ability to provide visualization of thermal lesions produced by high-intensity focused ultrasound and also to examine any characteristic differences in the shape of the lesions formed at different threshold temperatures. The present study suggests that the NiSAA polyacrylamide hydrogel will be of a practical use in quality assurance in various applications of therapeutic ultrasound where thermal mechanisms are important.


Ultrasound in Medicine and Biology | 2011

THE ACUTE EFFECTS OF SMOKING ON THE CYCLIC VARIATIONS IN BLOOD ECHOGENICITY OF CAROTID ARTERY

Ying Li; Tae-Hoon Bok; Jeong-Hwa Yang; Min-Joo Choi; Dong-Guk Paeng

The objective of this research is to study the cyclic variations in echogenicity (CVE) as an acute response to smoking. CVEs, caused by the aggregation of red blood cells (RBC) were measured from the cross-sectional images of the common carotid artery using coded harmonic imaging of a commercial ultrasound system. The amplitude of the CVE (A(cve)) was analyzed among 28 smokers before and after smoking. A(cve) was increased in 22 smokers and decreased in six smokers after 1-2 cigarettes were smoked. Heart rate (HR) was also estimated from the ultrasonic images before and after smoking. The smokers were optimally divided into two clusters with respect to the change in A(cve) and the intrinsic characteristics of smokers (i.e., daily consumed cigarettes and smoking years) through a two-step cluster analysis (TSCA). The increase in A(cve) after smoking was significantly higher in the heavy smoker cluster compared with the light smoker cluster. The results suggest that the acute changes in A(cve) in response to smoking are different between heavy smokers and light smokers. This preliminary study demonstrates the potential application of coded harmonic ultrasound imaging to detect or characterize RBC aggregation. In addition, the results may be useful for understanding the acute physiologic changes caused by smoking.


Japanese Journal of Applied Physics | 2003

Ultrasound: An Unexplored Tool for Blood Flow Visualization and Hemodynamic Measurements

K. Kirk Shung; Dong-Guk Paeng

Ultrasonic scattering by blood has been studied both theoretically and experimentally for a better characterization of the performance of ultrasonic devices. In the course of these investigations it became clear that ultrasonic scattering from blood is critically related to the hematological and hemodynamic properties of blood, including hematocrit, plasma protein concentration, flow rate, and flow cycle duration, to name a few parameters. An unexpected conclusion from this work is that ultrasound appears to be a totally unexplored and ignored tool for blood flow visualization and hemodynamic measurements. Two unique hemodynamic phenomena have been observed: the black hole, a low echogenic zone in the center stream of a blood vessel, and the collapsing ring, an hyperechogenic ring converging from the vessel periphery toward the center, and eventually collapsing during pulsatile flow. They seemed to be resulted from the spatial and temporal variations of the shear rate and acceleration in the vessel.


Ultrasonics | 2014

Effects of red blood cell aggregates dissociation on the estimation of ultrasound speckle image velocimetry.

Eunseop Yeom; Kweon-Ho Nam; Dong-Guk Paeng; Sang Joon Lee

Ultrasound speckle image of blood is mainly attributed by red blood cells (RBCs) which tend to form RBC aggregates. RBC aggregates are separated into individual cells when the shear force is over a certain value. The dissociation of RBC aggregates has an influence on the performance of ultrasound speckle image velocimetry (SIV) technique in which a cross-correlation algorithm is applied to the speckle images to get the velocity field information. The present study aims to investigate the effect of the dissociation of RBC aggregates on the estimation quality of SIV technique. Ultrasound B-mode images were captured from the porcine blood circulating in a mock-up flow loop with varying flow rate. To verify the measurement performance of SIV technique, the centerline velocity measured by the SIV technique was compared with that measured by Doppler spectrograms. The dissociation of RBC aggregates was estimated by using decorrelation of speckle patterns in which the subsequent window was shifted as much as the speckle displacement to compensate decorrelation caused by in-plane loss of speckle patterns. The decorrelation of speckles is considerably increased according to shear rate. Its variations are different along the radial direction. Because the dissociation of RBC aggregates changes ultrasound speckles, the estimation quality of SIV technique is significantly correlated with the decorrelation of speckles. This degradation of measurement quality may be improved by increasing the data acquisition rate. This study would be useful for simultaneous measurement of hemodynamic and hemorheological information of blood flows using only speckle images.


Ultrasonics | 2014

Asymmetric radial expansion and contraction of rat carotid artery observed using a high-resolution ultrasound imaging system.

Kweon-Ho Nam; Tae-Hoon Bok; Changzhu Jin; Dong-Guk Paeng

The geometry of carotid artery bifurcation is of high clinical interest because it determines the characteristics of blood flow that is closely related to the formation and development of atherosclerotic plaque. However, information on the dynamic changes in the vessel wall of carotid artery bifurcation during a pulsatile cycle is limited. This pilot study investigated the cyclic changes in carotid artery geometry caused by blood flow pulsation in rats. A high-resolution ultrasound imaging system with a broadband scanhead centered at 40 MHz was used to obtain longitudinal images of the rat carotid artery. A high frame rate retrospective B-scan imaging technique based on the use of electrocardiogram to trigger signal acquisition was used to examine precisely the fast arterial wall motion. Two-dimensional geometry data obtained from nine rats showed that the rat carotid artery asymmetrically contracts and dilates during each cardiac cycle. Systolic/diastolic vessel diameters near the upstream and downstream regions from the bifurcation were 0.976 ± 0.011/0.825 ± 0.015 mm and 0.766 ± 0.015/0.650 ± 0.016 mm, respectively. Their posterior/anterior wall displacement ratios in the radial direction were 41.0 ± 14.9% and 2.9 ± 1.6%, respectively. These results indicate that in the vicinity of bifurcation, the carotid artery favorably expands to the anterior side during the systolic phase. This phenomenon was observed to be more prominent in the downstream region near the bifurcation. The cyclic variation pattern in wall movement varies depending on the measurement site, which shows different patterns at far upstream and downstream of the bifurcation. The asymmetric radial expansion and contraction of the rat carotid artery observed in this study may be useful in studying the hemodynamic etiology of cardiovascular diseases because the pulsatile changes in vessel geometry may affect the local hemodynamics that determines the spatial distribution of wall shear stress, one of important cardiovascular risk factors. Further systematic study is needed to clarify the effects of wall elasticity, branch angle and vessel diameter ratio on the asymmetric wall motion of carotid artery bifurcation.

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Juho Kim

Jeju National University

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K. Kirk Shung

University of Southern California

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Kweon-Ho Nam

Pohang University of Science and Technology

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Kweon-Ho Nam

Pohang University of Science and Technology

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Jinho Bae

Jeju National University

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Chong Hyun Lee

Jeju National University

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Min Joo Choi

Jeju National University

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Changzhu Jin

Jeju National University

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