Doo-Hoon Song

Tailoring of antibacterial Ag nanostructures on TiO2 nanotube layers by magnetron sputtering

To reduce the incidence of postsurgical bacterial infection that may cause implantation failure at the implant-bone interface, surface treatment of titanium implants with antibiotic materials such as silver (Ag) has been proposed. The purpose of this work was to create TiO2 nanotubes using plasma electrolytic oxidation (PEO), followed by formation of an antibacterial Ag nanostructure coating on the TiO2 nanotube layer using a magnetron sputtering system. PEO was performed on commercially pure Ti sheets. The Ag nanostructure was added onto the resulting TiO2 nanotube using magnetron sputtering at varying deposition rates. Field emission scanning electron microscopy and transmission electron microscopy were used to characterize the surface, and Ag content on the TiO2 nanotube layer was analyzed by X-ray diffraction and X-ray photoelectron spectroscopy. Scanning probe microscopy for surface roughness and contact angle measurement were used to indirectly confirm enhanced TiO2 nanotube hydrophilicity. Antibacterial activity of Ag ions in solution was determined by inductively coupled plasma mass spectrometry and antibacterial testing against Staphylococcus aureus (S. aureus). In vitro, TiO2 nanotubes coated with sputtered Ag resulted in significantly reduced S. aureus. Cell viability assays showed no toxicity for the lowest sputtering time group in the osteoblastic cell line MC3T3-E1. These results suggest that a multinanostructured layer with a biocompatible TiO2 nanotube and antimicrobial Ag coating is a promising biomaterial that can be tailored with magnetron sputtering for optimal performance.

Time-dependent growth of titania nanotubes from sputtered titanium thin films for bio-application

Summary form only given. TiO 2 nanotubes are biocompatible and many studies have been carried out for their biotechnological applications, especially in relation to drug carriers. The purpose of this study is to apply TiO 2 film on the variety of metal substrates that could be used as biomaterials, and by forming various depth of nanotubes on the films, biocompatibility of the TiO 2 nanotube and its ability as a carrier is applied to variety of materials according to various purposes. In this work, we present the fabrication of self-organized TiO 2 nanotubes layer that was grown from flat and thin sputter-deposited titanium (Ti) films on Si (100) wafer.

Conservative the effect of heat treatment on osteogenic property of sputtered antibacterial silver-titanium oxide nanocomposite films

Summary form only given. Silver-containing titanium oxide (Ag-TiOx) nanocomposite thin films were deposited on cp-Ti substrate using DC reactive magnetron sputtering system. After deposition, heat treatment process was performed under 600°C for 1 hour. It is well known fact that the success of dental implant surgery is dependent on the bone-implant osseointegration. Also, longterm success rate is dependent on the absence of bacteria surrounding the implants which can induce the bio-film formation. In this study, effect of heat treatment on osseointegration and mechanical behavior of the antibacterial sputtered films was investigated.

Enhanced funtion of human periodontal ligament cells cultured on nanoporous titanium surfaces

Summary form only given. Biological integration of implant to surrounding tissue is important process as it determines its clinical success and attraction of bone cells. Also, in order to reduce the problems of implant-related infections, many kinds of the surface treatment on titanium have been proposed. The formations of TiO 2 nanotubes on the titanium have been widely studied to improve the biocompatibility of the surface, and silver nanoparticles have been known to exhibit the antibacterial efficacy. The purpose of this study was to carry out surface treatment on titanium and observe response of human periodontal ligament (hPDL) cells using combination of nanotube formation and silver nanoparticles treatment.