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Archive | 1983

NMR Studies on Short Helices

Doris M. Cheng; Denise Frechet; L. S. Kan

This NMR study on short DNA helices has five general objectives: (1) to develop effective approaches in the assignment of proton and phosphorus resonances of short helices; (2) to calibrate the NMR theory as applied to nucleic acid; (3) to obtain the helical DNA conformational parameters as accurately as possible; (4) to serve as a model system for defected DNA studies, and (5) to serve as a model for protein-nucleic acid interactions.


Biochemistry | 1980

Proton nuclear magnetic resonance studies on dideoxyribonucleoside methylphosphonates

Lou S. Kan; Doris M. Cheng; Paul S. Miller; Junichi Yano; Paul O. P. Ts'o


Biopolymers | 1984

1H‐ and 31P‐nuclear magnetic resonance studies on the conformation of d‐(CpGpCpG)2 and d‐(CpGpCpGpCpG)2 short helices in B‐conformation

Doris M. Cheng; Lou-Sing Kan; Denise Frechet; Paul O. P. Ts'o; Seiichi Uesugi; Toshio Shida; Morio Ikehara


Biochemistry | 1982

Proton nuclear magnetic resonance study of a self-complementary decadeoxyribonucleotide, C-C-A-A-G-C-T-T-G-G

Lou Sing Kan; Doris M. Cheng; Krishna Jayaraman; Eldon E. Leutzinger; Paul S. Miller; Paul O. P. Ts'o


Biochemistry | 1982

Conformational study of two short pentadeoxyribonucleotides, d-CpCpApApG and d-CpTpTpGpG, and their fragments by proton nuclear magnetic resonance

Doris M. Cheng; Lou Sing Kan; Eldon E. Leutzinger; Krishna Jayaraman; Paul S. Miller; Paul O. P. Ts'o


Biopolymers | 1980

1H- and 13C-NMR studies on caffeine and its interaction with nucleic acids.

Lou-Sing Kan; Philip N. Borer; Doris M. Cheng; Paul O. P. Ts'o


Biopolymers | 1984

Contributions of the PO ester and CO torsion angles of the phosphate group to 31P-nuclear magnetic shielding constant in nucleic acids: Theoretical and experimental study of model compounds

Claude Giessner-Prettre; Bernard Pullman; Fernando Ribas Parado; Doris M. Cheng; Virginia L. Iuorno; Paul O. P. Ts'o


Biochemistry | 1980

Preparation of a decadeoxyribonucleotide helix for studies by nuclear magnetic resonance

Paul S. Miller; Doris M. Cheng; Nathan Dreon; Krishna Jayaraman; Lou Sing Kan; Eldon E. Leutzinger; Stephen M. Pulford; Paul O. P. Ts'o


Biopolymers | 1982

An effective method for the assignment of 31P-NMR resonance(s) of oligonucleotides.

Doris M. Cheng; Lou-Sing Kan; Paul S. Miller; Eldon E. Leutzinger; Paul O. P. Ts'o


Biopolymers | 1983

Multinuclear magnetic resonance studies of monomers and diemrs containing 2′-fluoro-2′-deoxyadenosine

Doris M. Cheng; Lou-Sing Kan; Paul O. P. Ts'o; Seiichi Uesugi; Yoko Takatsuka; Morio Ikehara

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Lou-Sing Kan

Johns Hopkins University

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Paul S. Miller

Johns Hopkins University

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Lou Sing Kan

Johns Hopkins University

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Denise Frechet

Johns Hopkins University

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