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Dive into the research topics where Krishna Jayaraman is active.

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Featured researches published by Krishna Jayaraman.


Nucleosides, Nucleotides & Nucleic Acids | 1993

Synthesis of Cholesteryl Supports and Phosphoramidite for Automated DNA Synthesis of Triple-Helix Forming Oligonucleotides (Tfos)

Huynh Vu; Pradeep Singh; Laurie Lewis; Joseph G. Zendegui; Krishna Jayaraman

Abstract DMT-Cholesteryl succinylamino solid supports (CPG, loading: 33 μmole/gram and TentaGel loading: 152 μmole/gram) and DMT-cholesteryl phosphoramidite were prepared for use in automated DNA synthesis of cholesteryl modified TFOs in the synthesis scales from 0.2 to 300 μmole. The modified TFOs were found to have a 5 to 50 fold increase in their uptake properties.


Nucleosides, Nucleotides & Nucleic Acids | 1995

Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides

Krishna Jayaraman; Ross H. Durland; T. S. Rao; Ganapathi R. Revankar; V. Bodepudi; Nilabh Chaudhary; J. Guy-Caffey

Abstract The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of oligonucleotides.


Nucleosides, Nucleotides & Nucleic Acids | 1994

Synthesis of Triple Helix Forming Oligonucleotides with a Stretched Phosphodiester Backbone

T. Sudhakar Rao; Krishna Jayaraman; Ross H. Durland; Ganapathi R. Revankar

Abstract Total synthesis of novel DMT-phosphoramidites of thymidine (11 and 15) and 2′-deoxyguanosine (8 and 20) have been accomplished. The utility of these modified building blocks in the preparation of triple helix forming oligodeoxyribonucleotides with a stretched phosphodiester backbone has been evaluated. It was found that the oligonucleotides with extended backbones were unable to enhance the binding to duplex targets containing CG or TA base pairs.


Nucleic Acids Research | 1993

In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide

Nancy H. Ing; Johanna M. Beekman; Donald Joseph Kessler; Mark W. Murphy; Krishna Jayaraman; Joseph G. Zendegui; Michael E. Hogan; Bert W. O'Malley; Ming-Jer Tsai


Archive | 1995

Amphipathic nucleic acid transporter

Nilabh Chaudhary; Krishna Jayaraman; Veeraiah Bodepudi; Michael Hogan


Nucleic Acids Research | 1995

New efficient sulfurizing reagents for the preparation of oligodeoxyribonucleotide phosphorothioate analogues

Vladimir A. Efimov; A. L. Kalinkina; O. G. Chakhmakhcheva; Theresa Schmaitz Hill; Krishna Jayaraman


Nucleic Acids Research | 1995

Azole substituted oligonucleotides promote antiparallel triplex formation at non-homopurine duplex targets

Ross H. Durland; T. Sudhakar Rao; Veeraiah Bodepudi; Dale M. Seth; Krishna Jayaraman; Ganapathi R. Revankar


Nucleic Acids Research | 1994

Inhibition of T7 and T3 RNA polymerase directed transcription elongation in vitro

Robert F. Rando; Laura DePaolis; Ross H. Durland; Krishna Jayaraman; Donald J. Kessier; Michael E. Hogan


Nucleic Acids Research | 1994

Binding of T and T analogs to CG base pairs in antiparallel triplexes

Ross H. Durland; T. Sudhakar Rao; Ganapathi R. Revankar; John H. Tinsley; Melissa A. Myrick; Dale M. Seth; Jamie Rayford; Pradeep Singh; Krishna Jayaraman


Bioconjugate Chemistry | 1994

Synthesis and Properties of Cholesteryl-Modified Triple-Helix Forming Oligonucleotides Containing a Triglycyl Linker

Huynh Vu; Theresa Schmaltz Hill; Krishna Jayaraman

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Ross H. Durland

Baylor College of Medicine

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Chen Feng

University of Houston

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Rahul Mitra

Baylor College of Medicine

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Yuriy Fofanov

University of Texas Medical Branch

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