Krishna Jayaraman
University of Rochester
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Publication
Featured researches published by Krishna Jayaraman.
Nucleosides, Nucleotides & Nucleic Acids | 1993
Huynh Vu; Pradeep Singh; Laurie Lewis; Joseph G. Zendegui; Krishna Jayaraman
Abstract DMT-Cholesteryl succinylamino solid supports (CPG, loading: 33 μmole/gram and TentaGel loading: 152 μmole/gram) and DMT-cholesteryl phosphoramidite were prepared for use in automated DNA synthesis of cholesteryl modified TFOs in the synthesis scales from 0.2 to 300 μmole. The modified TFOs were found to have a 5 to 50 fold increase in their uptake properties.
Nucleosides, Nucleotides & Nucleic Acids | 1995
Krishna Jayaraman; Ross H. Durland; T. S. Rao; Ganapathi R. Revankar; V. Bodepudi; Nilabh Chaudhary; J. Guy-Caffey
Abstract The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of oligonucleotides.
Nucleosides, Nucleotides & Nucleic Acids | 1994
T. Sudhakar Rao; Krishna Jayaraman; Ross H. Durland; Ganapathi R. Revankar
Abstract Total synthesis of novel DMT-phosphoramidites of thymidine (11 and 15) and 2′-deoxyguanosine (8 and 20) have been accomplished. The utility of these modified building blocks in the preparation of triple helix forming oligodeoxyribonucleotides with a stretched phosphodiester backbone has been evaluated. It was found that the oligonucleotides with extended backbones were unable to enhance the binding to duplex targets containing CG or TA base pairs.
Nucleic Acids Research | 1993
Nancy H. Ing; Johanna M. Beekman; Donald Joseph Kessler; Mark W. Murphy; Krishna Jayaraman; Joseph G. Zendegui; Michael E. Hogan; Bert W. O'Malley; Ming-Jer Tsai
Archive | 1995
Nilabh Chaudhary; Krishna Jayaraman; Veeraiah Bodepudi; Michael Hogan
Nucleic Acids Research | 1995
Vladimir A. Efimov; A. L. Kalinkina; O. G. Chakhmakhcheva; Theresa Schmaitz Hill; Krishna Jayaraman
Nucleic Acids Research | 1995
Ross H. Durland; T. Sudhakar Rao; Veeraiah Bodepudi; Dale M. Seth; Krishna Jayaraman; Ganapathi R. Revankar
Nucleic Acids Research | 1994
Robert F. Rando; Laura DePaolis; Ross H. Durland; Krishna Jayaraman; Donald J. Kessier; Michael E. Hogan
Nucleic Acids Research | 1994
Ross H. Durland; T. Sudhakar Rao; Ganapathi R. Revankar; John H. Tinsley; Melissa A. Myrick; Dale M. Seth; Jamie Rayford; Pradeep Singh; Krishna Jayaraman
Bioconjugate Chemistry | 1994
Huynh Vu; Theresa Schmaltz Hill; Krishna Jayaraman