Douwe Rosenberg

Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging

Pharmaceutical compositions comprising gadolinium chelates are useful for enhancing NMR images.

Sterile composition comprising a chelate complex for magnetic resonance imaging

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.

A carbenoid route to C(1)–C(11) bridged steroids

Abstract The exocyclic olefin 3 enters into stereoselective cyclopropanations with dihalocarbenes on the steroid β-face to afford the protected spiro[2.5]octane analogues 4 and 5 . These intermediates are transformed into novel, highly strained steroid derivatives, like 9 , by utilizing an intramolecular cyclopropylidene insertion reaction en route to pentacyclic, C(1)–C(11) ethano-bridged steroids 13–20 .