Franz-Josef Renneke

Sterile composition comprising a chelate complex for magnetic resonance imaging

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.

NMR imaging using paramagnetic chelates having hydroxyalkyl-substituted amide groups

Compounds of the general formula I: ##STR1## R1 signifies a COOX group or the group ##STR2## R2 and R3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R2 or R3 signifies the group ##STR3## or R2 or R3 together signify a trimethylene or tetramethylene radical, R4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## wherein j signifies the numbers 1 to 4 and Rx signifies a hydrogen atom, a lower alkoxy group with 1 to 4 carbon atoms, a COOX group, or if j>1, also the group ##STR5## wherein k and m are the same or different and represent the numbers 0 or 2, l signifies the numbers 1 or 2 and n and w are the same or different and signify the numbers 0 or 1, wherein n and w can only represent the number 1, if k and m signify the number 2, and X represents hydrogen atoms and/or metal ion equivalents, and their salts with physiologically harmless organic bases, are valuable complexing agents, complexes and complex salts for NMR imaging.