Dzintra Muceniece

Recyclization of polysubstituted pyridinium salts

Abstract 3,5-Diacetyl- and 3,5-dicyano-1,2,6-trimethylpvridinium perchlorates are converted by recyclization into N,5-dimethylanilines and 2-methylaminopyridines, respectively.

Synthesis of 1,9a-dihydro-9a-substituted fluorenones and their 4-aza analogues

Abstract Cyclization of 2,2-disubstituted indan-1,3-dione with CH3COONH4 yields 9a-substituted 1,9a-dihydrofluorenone and 9H-4a, 5-dihydroindeno(1,2-b)pyridine derivatives.

Synthesis and isomerization of 1H-4,4a,5,9b-tetrahydroindeno- [1,2-b]pyridines

Abstract Synthesis of 1H-4,4a,5,9b-tetrahydroindeno[1,2-b]pyridines has been accomplished by catalytic hydrogenation of 4H-4a-5-dihydroindenopyridines. The isomerization of 1H-4,4a,5,9b-tetrahydroindenopyridines containing an acyl function at C-3 leads to 3H-4,4a,5,9b-tetrahydroindenopyridines in acidic medium.

Synthesis of novel 3-substituted benzamides related to imatinib

Twelve new 3-substituted benzamide derivatives structurally related to tyrosine kinase inhibitor imatinib have been synthesised by a Cu(I)-catalysed coupling of three previously synthesised (5-iodo-2-methylphenyl)-[4-(pyridin-3-yl)-6-perfluoroalkylpyrimidin-2-yl]amines with four synthesised 3-substituted 4-(4-methylpiperazin-1-ylmethyl)benzamides.

Synthesis of 6-t rifluoromethyl derivatives of 2-arylamino-4-(pyridin-3-yl) pyrimidines

The 6-trifluoromethyl derivative of a well known tyrosine kinase inhibitor, nilotinib, as well as some novel 6-trifluoromethyl substituted 2-arylamino-4-(pyridin-3-yl) pyrimidines were synthesised.