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Featured researches published by Eckhard Schwenner.


International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | 1991

Synthesis of [isopropyl-11C]nimodipine for in vivo studies of dihydropyridine binding in man using positron emission tomography

Sharon Stone-Elander; Per E. Roland; Eckhard Schwenner; Christer Halldin; Lennart Widén

Nimodipine, an antagonist of the L-type calcium ion channel, was labelled with 11C for in vivo positron emission tomography studies of dihydropyridine binding in the human brain. The synthesis was based on esterification of the corresponding acid (W2100) using [2-11C]isopropyl iodide as the labelling precursor. The effects of different bases, solvent mixtures and reaction temperatures on radiochemical yields were investigated. The synthesis including purification by semi-preparative reversed-phase HPLC, required 60-65 min. Conversion of [2-11C]isopropyl iodide to [isopropyl-11C] nimodipine was of the order of 60-80%. The radiochemical yield (isolated) was 20-25%, based on [11C]carbon dioxide. The specific activity of the isolated product varied from 4-40 GBq/mumol (end-of-synthesis).


Archive | 1994

Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics

Antonius L obberding; Burkhard Mielke; Christoph Schwemler; Eckhard Schwenner; Udo Stropp; Wolfgang Springer; Axel Kretschmer; Thorsten P otter


Archive | 1993

Piperazine-substituted pyrroloanthracenes

Eckhard Schwenner; Gaetan Ladouceur; Hans-Joachim Kabbe; Thomas M. Aune


Archive | 1993

Substituted pyrroloanthracenes and -diones

Eckhard Schwenner; Gaetan Ladouceur; Hans-Joachim Kabbe; Thomas M. Aune


Archive | 1985

1,4-dihydropyridine hydroxyamines, process for their preparation and their use as pharmaceutical agents

David Triggle; Eckhard Schwenner; Günther Dr. Kinast; Stanislav Kazda; Andreas Dr. Knorr; Bernward Garthoff


Archive | 1994

Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik

Axel Kretschmer; Antonius Dr. Löbberding; Burkhard Mielke; Thorsten Pötter; Christoph Schwemler; Eckhard Schwenner; Wolfgang Springer; Udo Stropp


Archive | 1994

Nucleic acid binding oligomers having C-branches for therapy and diagnosis

Antonius Dr. Löbberding; Burkhard Mielke; Christoph Schwemler; Eckhard Schwenner; Udo Stropp; Wolfgang Springer; Axel Kretschmer; Thorsten Pötter


Archive | 1994

Anthracene spiro-pyrrolidines as immuno-modulators

Eckhard Schwenner; Gaéton Ladouceur; Thomas M. Aune


Archive | 1987

Dihydropyridine-2-hydroxyamines, process for their preparation and their use in medicaments.

Eckhard Schwenner; Günther Dr. Kinast; Andreas Dr. Knorr; Stanislav Kazda


Archive | 1988

Dihydropyridinamides, process for their preparation and their use in medicines

Jürgen Dipl.-Ing. Stoltefuss; Eckhard Schwenner; Martin Bechem; Claudia Hirth; Michael Kayser; Matthias Schramm; Johannes-Peter Stasch

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