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Ed W. McLean

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Journal of The Chemical Society, Chemical Communications | 1994

1,4-Diazabicyclo[2.2.2]octane (DABCO)-catalysed hydrolysis and alcoholysis reactions of 2-amino-9-benzyl-6-chloro-9H-purine

James A. Linn; Ed W. McLean; James L. Kelley

2-Amino-9-benzyl-6-chloro-9H-purine 1 is hydrolysed in refluxing water in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) to give 2-amino-9-benzyl-1,6-dihydro-6-oxo-9H-purine 3; however, 1 reacts with hydroxide ion at ambient temp., or analcohol and potassium carbonate at elevated temperatures, in the presence of DABCO togive 3 or 6-alkoxy-2-amino-9-benzyl-9H-purines 4–8, respectively.

Journal of Medicinal Chemistry | 1995

1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity.

James L. Kelley; Cecilia S. Koble; Ronda Davis; Ed W. McLean; Francis E. Soroko; Barrett R. Cooper

Journal of Medicinal Chemistry | 2005

Application of Phosphoramidate Pronucleotide Technology to Abacavir Leads to a Significant Enhancement of Antiviral Potency

Christopher McGuigan; Sarah Harris; Susan Daluge; Kristjan Gudmundsson; Ed W. McLean; Thimysta C. Burnette; Harry Marr; Richard J. Hazen; Lynn D. Condreay; Lance C. Johnson; Erik De Clercq; Jan Balzarini

Bioorganic & Medicinal Chemistry Letters | 2006

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.

John F. Miller; C. Webster Andrews; Michael Stephen Brieger; Eric S. Furfine; Michael R. Hale; Mary H. Hanlon; Richard J. Hazen; Istvan Kaldor; Ed W. McLean; David J. Reynolds; Douglas Mccord Sammond; Andrew Spaltenstein; Roger D. Tung; Elizabeth M. Turner; Robert X. Xu; Ronald G. Sherrill

Archive | 2003

Piperidine derivatives as ccr5 antagonists

Wieslaw M. Kazmierski; Christopher Joseph Aquino; Neil Bifulco; Eric E. Boros; Brian Andrew Chauder; Pek Yoke Chong; Maosheng Duan; Jr. Felix Deanda; Cecilia S. Koble; Ed W. McLean; Jennifer Poole Peckham; Angilique C Perkins; James B. Thompson; Dana Vanderwall

Journal of Medicinal Chemistry | 2006

Application of Phosphoramidate ProTide Technology Significantly Improves Antiviral Potency of Carbocyclic Adenosine Derivatives

Christopher McGuigan; Alshaimaa Hassan-Abdallah; Sheila Srinivasan; Yikang Wang; Adam Siddiqui; Susan Daluge; Kristjan Gudmundsson; Huiqiang Zhou; Ed W. McLean; Jennifer Poole Peckham; Thimysta C. Burnette; Harry Marr; Richard J. Hazen; Lynn D. Condreay; Lance C. Johnson; Jan Balzarini

Journal of Medicinal Chemistry | 1977

Attempted inhibition of histidine decarboxylase with beta-alkyl analogues of histidine.

James L. Kelley; Carl Miller; Ed W. McLean

Journal of Medicinal Chemistry | 2003

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.

David L. Musso; Felicia R. Cochran; James L. Kelley; Ed W. McLean; Jeffrey L. Selph; Greg C. Rigdon; G. Faye Orr; Ronda Davis; Barrett R. Cooper; Virgil L. Styles; James B. Thompson; William R. Hall

Journal of Medicinal Chemistry | 1995

[[(Guaninylalkyl)phosphinico]methyl]phosphonic acids. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.

James L. Kelley; Ed W. McLean; Ronald C. Crouch; Devron Averett; Joel Van Tuttle

Journal of Medicinal Chemistry | 1988

6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents

James L. Kelley; Mark P. Krochmal; James A. Linn; Ed W. McLean; Francis E. Soroko

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James L. Kelley

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Barrett R. Cooper

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James A. Linn

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Francis E. Soroko

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James B. Thompson

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James L. Howard

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Jennifer Poole Peckham

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Richard J. Hazen

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Ronda Davis

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Brian Andrew Chauder

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