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Ronda Davis

Research Triangle Park

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Publication

Featured researches published by Ronda Davis.

Bioorganic & Medicinal Chemistry Letters | 2000

The discovery of potent cRaf1 kinase inhibitors.

Karen Lackey; Michael Cory; Ronda Davis; Stephen V. Frye; Philip A. Harris; Robert Neil Hunter; David K. Jung; O.Bradley McDonald; Robert W. Mcnutt; Michael Robert Peel; Randy D. Rutkowske; James M. Veal; Edgar R. Wood

A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were the donor/acceptor motif common to kinase inhibitors and a critical acidic phenol flanked by two substitutions. Diverse 5-position substitutions provided compounds with low nanomolar kinase enzyme inhibition and inhibited the intracellular MAPK pathway.

Archive | 2001

Pyrimidineamines as angiogenesis modulators

Amogh Boloor; Mui GlaxoSmithKline Cheung; Ronda Davis; Philip A. Harris; Kevin GlaxoSmithKline Hinkle; Robert A. Mook; Jeffery Alan Stafford; James Martin Veal

Journal of Medicinal Chemistry | 1995

1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity.

James L. Kelley; Cecilia S. Koble; Ronda Davis; Ed W. McLean; Francis E. Soroko; Barrett R. Cooper

Journal of Medicinal Chemistry | 2003

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity.

David L. Musso; Felicia R. Cochran; James L. Kelley; Ed W. McLean; Jeffrey L. Selph; Greg C. Rigdon; G. Faye Orr; Ronda Davis; Barrett R. Cooper; Virgil L. Styles; James B. Thompson; William R. Hall

Journal of Medicinal Chemistry | 1995

Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine.

James L. Kelley; Ronda Davis; Ed W. McLean; Robert C. Glen; Francis E. Soroko; Barrett R. Cooper

Journal of Heterocyclic Chemistry | 1990

Synthesis of 6‐[[(hydroxyimino)phenyl]methyl]‐1‐[(1‐methylethyl)sulfonyl]‐1H‐imidazo[4,5‐b]pyridin‐2‐amine. An aza analogue of enviroxime

James L. Kelley; Ed W. McLean; Ronda Davis; Ronald C. Crouch

Archive | 2001

Pyrimidinamines AS ANGIOGENESEMODULATORER

Amogh Boloor; Mui Cheung; Ronda Davis; Philip A. Harris; Kevin Hinkle; Robert A. Mook; Jeffery Alan Stafford; James Martin Veal

Archive | 2001

Pyrimidinamine als angiogenesemodulatoren

Amogh Boloor; Mui GlaxoSmithKline Cheung; Ronda Davis; Philip A. Harris; Kevin GlaxoSmithKline Hinkle; Robert A. Mook; Jeffery Alan Stafford; James Martin Veal

Archive | 2001

Pyrimidineamines as modulators of angiogenesis.

Amogh Boloor; Mui Cheung; Ronda Davis; Philip A. Harris; Kevin Hinkle; Robert A. Mook; Jeffery Alan Stafford; James Martin Veal

Archive | 2001

Pyrimidineamines comme modulateurs de l'angiogenese

Amogh Boloor; Mui Cheung; Ronda Davis; Philip A. Harris; Kevin Hinkle; Robert A. Mook; Jeffery Alan Stafford; James Marvin Veal

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Philip A. Harris

GlaxoSmithKline

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Robert A. Mook

Research Triangle Park

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Mui Cheung

GlaxoSmithKline

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Ed W. McLean

Research Triangle Park

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James L. Kelley

Research Triangle Park

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Barrett R. Cooper

Research Triangle Park

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Francis E. Soroko

Research Triangle Park

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Cecilia S. Koble

Research Triangle Park

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David K. Jung

Research Triangle Park

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David L. Musso

Research Triangle Park

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