Eddy Yusuf

Effect of Different Extraction Techniques of Persicaria odorata Extracts Utilizing Anti-bacterial Bioassay

Persicaria odorata is a common plant and well known in Malaysia as “ Daun kesum ” that is commonly used in cuisines and has various medicinal properties. This study was conducted to investigate the antimicrobial activity and the extraction technique that

Synthesis of cinnamic acid amide derivatives and the biological evaluation of A-Glucosidase inhibitory activity

Diabetes mellitus is a chronic metabolic disease associated with increased risk factors for morbidity and mortality. The treatment of diabetes is by reduction in postprandial hyperglycaemia via the inhibition of a-glucosidase. The aim of this research is to determine the inhibition of a-glucosidase activity on the synthesized cinnamic acid amide derivatives. A series of cinnamic acid amide derivatives (1–8) were synthesized and evaluated for inhibitory activity against a-glucosidases such as maltose and sucrose based on the structure-activity relationships. Among the eight synthesized compounds, compounds 3 and 4 which contained two hydroxyl group at the meta and para position of the cinnamic acid structure, displayed the highest activity of a-glucosidases inhibition for both maltose and sucrose. These results suggested that cinnamic acid amide such as compound 3, caffeoyl benzylamide, and compound 4, caffeoyl cyclohexylmethylamide, may serve as a lead compound for the development of novel a-glucosidases inhibitors and can be useful for the treatment of diabetes mellitus and its complications.

Related Topic: Halal Cosmetics

Halal is an Arabic word, which means permissible or lawful by Islamic Law (shariah).It refers to the whole system of principles and rules, according to which every Muslim is required to live by.Halal products are a basic need for all Muslims, including cosmetic and personal care products. Halal cometic products should be looked at beyond the swine-free issue. They cover all aspects of the management system, including selection of raw materials/ingredients, built-in production processes, storage, distribution, transportation, and delivery to the consumer. Currently halal products are not only important for Muslims, but are also attracting non-Muslims due to cleanliness, purity, and good quality products.Detection of non-halal ingredients in cosmetic products is quite difficult due to the high complexity of ingredient usage. Therefore, developing methods of analysis are important to ensure halal authenticity and integrity. Halal standards and halal certification is important as a benchmark for halal compliance.