Eduardo R. Carvalho
Federal University of Ceará
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Featured researches published by Eduardo R. Carvalho.
Brazilian Journal of Cardiovascular Surgery | 2011
Heraldo Guedis Lobo Filho; Nestor Lemos Ferreira; Rafael Bezerra de Sousa; Eduardo R. Carvalho; Patrícia Leal Dantas Lobo; José Glauco Lobo Filho
OBJECTIVE: To evaluate and validate, in our laboratory, the essay of myocardial infarction induced by isoproterenol in rats by means of analysis of hematological, biochemical, oxidative stress markers and histopathological parameters. METHODS: Thirty young, male, Wistar rats (145 to 230 g) were randomly allocated in two groups: Sham group, which underwent a virtual myocardial infarction induction, and the Infarction group, which underwent a myocardial infarction induction with isoproterenol. The administrations for the infarction induction were performed during two consecutive days and a 24-hour interval between them. Twenty-four hours after the last administration, rats from both groups were anesthetized and sacrificed for blood sample collection to evaluate complete blood count (CBC) and biochemical parameters (SGOT, SGPT, troponin I, urea and creatinin), obtain myocardial fragments for oxidative stress markers analyses (catalase activity and glutathione concentrations) as well as histopathological examinations. RESULTS: There were no death cases in the Sham group, while the mortality rate in the Infarction group was 25%. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, SGOT, troponin I and urea concentrations, reduced catalase enzyme activity and glutathione concentrations in the myocardium and let to histopathological concentrations as well. It did not exert alterations in terms of hemoglobin, SGPT and creatinin concentrations. CONCLUSIONS: The isoproterenol-induced myocardial infarction essay in rats was adequately reproduced in our laboratory, causing alterations in hematological, biochemical, oxidative stress markers and histopathological parameters.OBJECTIVE To evaluate and validate, in our laboratory, the essay of myocardial infarction induced by isoproterenol in rats by means of analysis of hematological, biochemical, oxidative stress markers and histopathological parameters. METHODS Thirty young, male, Wistar rats (145 to 230 g) were randomly allocated in two groups: Sham group, which underwent a virtual myocardial infarction induction, and the Infarction group, which underwent a myocardial infarction induction with isoproterenol. The administrations for the infarction induction were performed during two consecutive days and a 24-hour interval between them. Twenty-four hours after the last administration, rats from both groups were anesthetized and sacrificed for blood sample collection to evaluate complete blood count (CBC) and biochemical parameters (SGOT, SGPT, troponin I, urea and creatinin), obtain myocardial fragments for oxidative stress markers analyses (catalase activity and glutathione concentrations) as well as histopathological examinations. RESULTS There were no death cases in the Sham group, while the mortality rate in the Infarction group was 25%. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, SGOT, troponin I and urea concentrations, reduced catalase enzyme activity and glutathione concentrations in the myocardium and let to histopathological concentrations as well. It did not exert alterations in terms of hemoglobin, SGPT and creatinin concentrations. CONCLUSIONS The isoproterenol-induced myocardial infarction essay in rats was adequately reproduced in our laboratory, causing alterations in hematological, biochemical, oxidative stress markers and histopathological parameters.
Brazilian Journal of Cardiovascular Surgery | 2013
Maria Cláudia de Azevedo Leitão; José Glauco Lobo Filho; Tiago M. Freire; Marília Leitão Montenegro; Francisco Vagnaldo Fechine Jamacuru; Eduardo R. Carvalho; Amanda X. Couto Bem; Heraldo Guedis Lobo Filho; Manuel Odorico de Moraes Filho
OBJECTIVES The purpose of our study was to establish, with an entirely noninvasive method, transthoracic Doppler echocardiography, criteria for patency of composite left internal thoracic artery grafts when placed on the left anterior descending artery and other branches of the left coronary system. METHODS The control group comprised 20 patients with single graft and 20 patients with composite graft; all forty having their patency confirmed by coronary angiogram (CA). In this control group, two Doppler echocardiographic variables, diastolic mean velocity-time and integral diastolic peak velocity to systolic peak velocity ratio were recorded. For each variable, established cut-off points were established, using the ROC (Receiver Operator Characteristic) curves, to identify criteria which could differentiate the composite grafts. Only patients with composite grafts were included in the 159-patients study group. The criteria established by the cut-off points in the control group were then applied to detect patency using a diastolic fraction of > 0.5 as the gold standard. The sensitivity, specificity, and positive and negative predictive values of these two criteria were determined. RESULTS In the control group, cut-off points of 0.71 and 0.09 m were established for the diastolic peak velocity/systolic peak velocity ratio and for diastolic mean velocity-time integral, respectively. In the study group phase, the sensitivity and negative predictive value of the diastolic peak velocity/systolic peak velocity > 0.71 criterion were 36% and 11%, respectively. Diastolic mean velocity-time integral > 0.09 m criterion, were 40% and 10.48%. The specificities and positive predictive values of each criterion were 100%. CONCLUSION Values reaching the criteria established for each variable indicate high probability of composite graft patency. Lower values have a large proportion of false negatives and are not conclusive as patency criteria.
Quality of Life Research | 2011
Saulo C. Albuquerque; Eduardo R. Carvalho; Rebeka S. Lopes; Higor S. Marques; Danielle Silveira Macêdo; Eanes Delgado Barros Pereira; Thomas Hyphantis; André F. Carvalho
Revista Brasileira de Psiquiatria | 2010
Milena S. Castelo; Eduardo R. Carvalho; Emília S. Gerhard; Carlos Maurício de Castro Costa; Eduardo D. Ferreira; André F. Carvalho
Jornal Brasileiro De Psiquiatria | 2010
Milena S. Castelo; Eduardo R. Carvalho; Emília S. Gerhard; Danielle Silveira Macêdo; Eduardo D. Ferreira; André F. Carvalho
Archive | 2014
José Glauco Lobo Filho; Heraldo Guedis Lobo Filho; Eduardo R. Carvalho
American Journal of Cardiology | 2014
H.G. Lobo Filho; Diego Felipe Gaia; J.G. Lobo Filho; José Honório Palma; Enio Buffolo; Eduardo R. Carvalho; Patrícia Leal Dantas Lobo; Carolina Baeta Neves Duarte Ferreira; João Roberto Breda; J.A. De Souza; F.S. De Medeiros; C. C. Leão Filho
European Respiratory Journal | 2011
Saulo C. Albuquerque; Eduardo R. Carvalho; Rebeka S. Lopes; Igor S. Marques; Daniele S. Macêdo; Eanes Delgado Barros Pereira; Thomas Hyphantis; André F. Carvalho
Archive | 2010
Milena S. Castelo; Eduardo R. Carvalho; Emília S. Gerhard; Danielle Silveira Macêdo; Eduardo D. Ferreira; André F. Carvalho
Archive | 2010
Milena S. Castelo; Eduardo R. Carvalho; Emília S. Gerhard; Carlos Maurício; Carlos Maurício de Castro Costa; Eduardo D. Ferreira; André F. Carvalho