Edward D. Light

Progress in Two-Dimensional Arrays for Real-Time Volumetric Imaging

The design, fabrication, and evaluation of two dimensional array transducers for real-time volumetric imaging are described. The transducers we have previously described operated at frequencies below 3 MHz and were unwieldy to the operator because of the interconnect schemes used in connecting to the transducer handle. Several new transducers have been developed using new connection technology. A 40 × 40 = 1,600 element, 3.5 MHz array was fabricated with 256 transmit and 256 receive elements. A 60 × 60 = 3,600 element 5.0 MHz array was constructed with 248 transmit and 256 receive elements. An 80 × 80 = 6,400 element, 2.5 MHz array was fabricated with 256 transmit and 208 receive elements. 2-D transducer arrays were also developed for volumetric scanning in an intracardiac catheter, a 10 × 10 = 100 element 5.0 MHz forward-looking array and an 11 × 13 = 143 element 5.0 MHz side-scanning array. The −6 dB fractional bandwidths for the different arrays varied from 50% to 63%, and the 50 Ω insertion loss for all the transducers was about −64 dB. The transducers were used to generate real-time volumetric images in phantoms and in vivo using the Duke University real time volumetric imaging system, which is capable of generating multiple planes at any desired angle and depth within the pyramidal volume.

Imaging catheters for volumetric intraluminal ultrasound imaging

A real time three dimensional ultrasound imaging probe apparatus is configured to be placed inside a body. The apparatus comprises an elongated body having proximal and distal ends with an ultrasonic transducer phased array connected to and positioned on the distal end of the elongated body. The ultrasonic transducer phased array is positioned to emit and receive ultrasonic energy for volumetric forward scanning from the distal end of the elongated body. The ultrasonic transducer phased array includes a plurality of sites occupied by ultrasonic transducer elements. At least one ultrasonic transducer element is absent from at least one of the sites, thereby defining an interstitial site. A tool is positioned at the interstitial site. In particular, the tool can be a fiber optic lead, a suction tool, a guide wire, an electrophysiological electrode, or an ablation electrode. Related systems are also discussed.

The Ultrasound Brain Helmet: Feasibility Study of Multiple Simultaneous 3D Scans of Cerebral Vasculature

We describe early stage experiments to test the feasibility of an ultrasound brain helmet to produce multiple simultaneous real-time three-dimensional (3D) scans of the cerebral vasculature from temporal and suboccipital acoustic windows of the skull. The transducer hardware and software of the Volumetrics Medical Imaging (Durham, NC, USA) real-time 3D scanner were modified to support dual 2.5 MHz matrix arrays of 256 transmit elements and 128 receive elements which produce two simultaneous 64 degrees pyramidal scans. The real-time display format consists of two coronal B-mode images merged into a 128 degrees sector, two simultaneous parasagittal images merged into a 128 degrees x 64 degrees C-mode plane and a simultaneous 64 degrees axial image. Real-time 3D color Doppler scans from a skull phantom with latex blood vessel were obtained after contrast agent injection as a proof of concept. The long-term goal is to produce real-time 3D ultrasound images of the cerebral vasculature from a portable unit capable of internet transmission thus enabling interactive 3D imaging, remote diagnosis and earlier therapeutic intervention. We are motivated by the urgency for rapid diagnosis of stroke due to the short time window of effective therapeutic intervention.

Real-time three-dimensional intracardiac echocardiography.

Using catheter-mounted 2-D array transducers, we have obtained real-time 3-D intracardiac ultrasound (US) images. We have constructed several transducers with 64 channels inside a 12 French catheter lumen operating at 5 MHz. The transducer configuration may be side-scanning or beveled, with respect to the long axis of the catheter lumen. We have also included six electrodes to acquire simultaneous electrocardiograms. Using an open-chest sheep model, we inserted the catheter into the cardiac chambers to study the utility of in vivo intracardiac 3-D scanning. Images obtained include a cardiac four-chamber view, mitral valve, pulmonic valve, tricuspid valve, interatrial septum, interventricular septum and ventricular volumes. We have also imaged two electrophysiological interventional devices in the right atrium, performed an in vitro ablation study, and viewed the pulmonary veins in vitro.

High-density flexible interconnect for two-dimensional ultrasound arrays

We present a method for fabricating flexible multilayer circuits for interconnection to 2-D array ultrasound transducers. In addition, we describe four 2-D arrays in which such flexible interconnect is implemented, including transthoracic arrays with 438 channels operating at up to 7 MHz and intracardiac catheter arrays with 70 channels operating at up to 7 MHz. We employ thin and thick film microfabrication techniques to batch produce the interconnect circuits with minimum dimensions of 12-/spl mu/m lines, 40-/spl mu/m vias, and 150-/spl mu/m array pitch. The arrays show 50-/spl Omega/ insertion loss of -60 to -84 dB and a fractional bandwidth of 27 to 67%. The arrays are used to obtain real time, in vivo volumetric scans.

Two-dimensional array transducers using thick film connection technology

A connection technique for two-dimensional array ultrasound transducers developed by combining a conductive lambda /4 mismatching layer with a multi-layer ceramic (MLC) connector using thick-film microelectronic technology is described. The connector consists of 20 thick films of alumina and screen printed metallization with customized interconnections between the layers called vias. Ten ground layers are interleaved between ten signal layers to reduce elecrical crosstalk. A lambda /4 mismatching layer of conductive epoxy is bonded between each PZT element and the silver metal pad of the MLC connector to provide an effective low impedance backing. In the current configuration, a 16*16 transducer array, 0.6 mm element spacing, is expanded to a 16*16 grid of connector pins at a standard spacing of 2.5 mm. Vector impedance, sensitivity, bandwidth, interelement uniformity, and crosstalk are all in good agreement with arrays of conventional fabrication. However, an array with MLC connector can be fabricated more quickly independent of the number of elements.<<ETX>>

Update on 2-D array transducers for medical ultrasound

l 1/2 -D and 2-D arrays offer a myriad of new imaging modalities and benefits when compared to the linear array. However, with added benefits come many problems and challenges and l 1/2 -D and 2-D arrays are no exception. The authors give possible solutions to a number of these challenges. The increase in transducer channels needed in a 1 1/2 -D and 2-D array can be reduced using a sparse periodic or sparse random array. The complexity of the fabrication is overcome using a multilayer flexible connector designed and fabricated using microelectronic techniques. The low SNR of 1 1/2 -D and 2-D arrays can be circumvented with the application of multi-layer ceramic elements to optimize the SNR given a specific transmit and receive configuration. In addition, optoelectronic transmitters allow for the reduction in size and increase in flexibility of the transducer cable because of the use of fiber optics. With the reduction in the number of channels, improvement in transducer fabrication, and increase in transducer SNR, l 1/2 -D and 2-D arrays will be accepted as viable replacements for the linear arrays of today.

Feasibility Study of Real-Time Three- Dimensional Intracardiac Echocardiography for Guidance of Interventional Electrophysiology

SMITH, S.W., et al.: Feasibility Study of Real‐Time Three‐Dimensional Intracardiac Echocardiography for Guidance of Interventional Electrophysiology. The authors tested the feasibility of real‐time three‐dimensional intracardiac echocardiography for guidance of interventional electrophysiological studies. The three‐dimensional scanner uses a matrix array ultrasound transducer of 64 channels operating at 5 MHz in a 12 Fr catheter. The system features real‐time three‐dimensional image rendering and produces up to 60 volumetric scans per second. Using an open‐chest sheep model, real‐time three‐dimensional images of anatomic landmarks were obtained, including the pulmonary veins and coronary sinus, which are of value in electrophysiological procedures. In vivo radio frequency ablation procedures in the right ventricle were also monitored, which yielded lesions of high image contrast.

Real-time 3D laparoscopic ultrasonography.

We have previously described 2D array ultrasound transducers operating up to 10 MHz for applications including real time 3D transthoracic imaging, real time volumetric intracardiac echocardiography (ICE), real time 3D intravascular ultrasound (IVUS) imaging, and real time 3D transesophageal echocardiography (TEE). We have recently built a pair of 2D array transducers for real time 3D laparoscopic ultrasonography (3D LUS). These transducers are intended to be placed down a trocar during minimally invasive surgery. The first is a forward viewing 5 MHz, 11 times 19 array with 198 operating elements. It was built on an 8 layer multilayer flex circuit. The interelement spacing is 0.20 mm yielding an aperture that is 2.2 mm × 3.8 mm. The O.D. of the completed transducer is 10.2 mm and includes a 2 mm tool port. The average measured center frequency is 4.5 MHz, and the −6 dB bandwidth ranges from 15% to 30%. The 50 Ω insertion loss, including Gore MicroFlat cabling, is −81.2 dB. The second transducer is a 7 MHz, 36 times 36 array with 504 operating elements. It was built upon a 10 layer multilayer flex circuit. This transducer is in the forward viewing configuration and the interelement spacing is 0.18 mm. The total aperture size is 6.48 mm x 6.48 mm. The O.D. of the completed transducer is 11.4 mm. The average measured center frequency is 7.2 MHz, and the −6 dB bandwidth ranges from 18% to 33%. The 50 Ω insertion loss is −79.5 dB, including Gore MicroFlat cable. Real-time in vivo 3D images of canine hearts have been made including an apical 4-chamber view from a substernal access with the first transducer to monitor cardiac function. In addition, we produced real time 3D rendered images of the right pulmonary veins from a right parasternal access with the second transducer, which would be valuable in the guidance of cardiac ablation catheters for treatment of atrial fibrillation.

Two Dimensional Arrays for Real Time 3D Intravascular Ultrasound

We have previously described 2D arrays operating at up to 10.0 MHz consisting of several thousand elements for transthoracic cardiac imaging and over a hundred elements for intracardiac imaging using 7 Fr to 12 Fr catheters. We have begun to explore forward viewing real time 3D phased array intravascular ultrasound, which may require imaging depths of a few centimeters to look down the axis of a vessel to view vulnerable atherosclerotic plaque. We used a noncoaxial based cable technology that allowed 100 signal wires to be placed inside a 4.8 French IVUS lumen with an inner diameter of 1.3 mm. We pursued two different fabrication technologies for the building of the transducers. Each transducer was constructed in the forward viewing configuration to allow simultaneous real time B-scans, C-scans and volumetric rendering of vessels and vascular stents distal to the catheter tip. In order to obtain the desired penetration depth, each transducer was constructed to operate at 10.0 MHz. The first method included an ordered array of 11 × 11 = 121 elements. In order to conform to the round aperture of the IVUS lumen, the corners were cut off, resulting in a total of 97 signal channels. Real time images include a 4 mm diameter vessel in a tissue mimicking phantom, an expanded stent and a stent in an excised sheep aorta. The second method is based upon a laser dicing technique that cuts the individual elements in a random pattern. This resulted in 61 signal channels. Real time 3D images of the AIUM test object were made with this transducer.