Edward E. Fischel

Failure of cortisone to affect rate of disappearance of antibody protein.

Summary 1. Four rabbits were given equal amounts of concentrated rabbit antipneumococcal globulin solution. Two of the rabbits were pretreated with cortisone and continued to receive the hormone. During the subsequent ten days, no difference was observed from the controls in the rate of disappearance of the “labeled” protein from the circulation. 2. Factors concerned with the interpretation of the data are discussed with reference to the effect of cortisone on protein metabolism.

The Antipyretic Effect of Cortisone.

Summary In a controlled study, cortisone has been found to be antipyretic in rabbits given pneumococcal vaccine and a pseudomonas pyrogen. The mechanism for this effect is not known.

Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions.

Summary A study was made of the effect of salicylate and of a synthetic antihistamine compound, tripelennamine hydrochloride, on necrotizing allergic reactions of the Arthus and “bacterial” types. The Arthus reaction was induced passively in rabbits by quantitative methods. “Bacterial” sensitivity to a streptococcus nucleoprotein fraction and to tuberculin was observed in human subjects. Neither type of reaction appeared to be altered by the administration of salicylate or tripelennamine. However, in the early development of the Arthus phenomenon, salicylate treated animals exhibited less edema at the site of the lesion.

Passive Cutaneous Anaphylaxis with Antigen-Antibody Complexes and Additional Antigen.

Summary Small amounts of antibody and excess antigen sensitize guinea pig skin so that challenge with intravenous antigen and dye elicits passive cutaneous anaphylaxis. The significance of the biological reactivity of antigen-antibody complexes is briefly discussed.

Effect of Phenergan (N-Dimethylamioo-2-Propyl-1-Thiodiphenyla-mine, 3277 RP) on the Arthus Reaction in Rabbits

Summary The effect of phenergan on the Arthus reaction was investigated, employing a quantitative method for the induction of the reaction. In large but non-lethal doses, the drug was found to inhibit appreciably the development of the more severe Arthus reactions. It is suggested that the action of the drug on the Arthus reaction is related to its effect on capillary permeability. A limited study of the inhibition by phenergan of the toxic effect of a large quantity of streptococcal erythrogenic toxin appears to support this view.

Suppression by cortisone of granuloma formation and antibody in guinea pigs receiving egg albumin with Freund adjuvants

Abstract The administration of large dosages of cortisone to guinea pigs receiving crystalline egg albumin with the Freund adjuvant resulted in marked reduction of antibody levels and in marked diminution of granuloma formation at the site of the antigen-adjuvant injection. The relationship of granuloma formation to antibody production is discussed in the light of these studies together with previous work on the omission of tubercle bacilli and on experimental encephalomyelitis.

Biologic reactivity of antigen and antibody in specific precipitate.

Summary The capacity of washed specific precipitate to sensitize guinea pigs so that a subsequent injection of antigen elicits systemic anaphylaxis is demonstrated. Capacity of specific precipitate to act as an antigenic challenge and elicit passive cutaneous anaphylaxis is also shown. Quantitative relationships of the amounts of antigen and antibody involved are noted.