Edward L. Fritzen

The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity.

A solid phase synthesis of substituted tetrahydroisoquinolines was developed and used to prepare directed libraries of compounds for screening against the protein phosphatase, CDC25B. From these libraries, a compound was found having approximately a 4-fold improvement in activity.

The palladium catalyzed allylic alkylation of bis(trimethylsilyl) substituted propenyl acetates or carbonates in the presence of chiral ligands

Abstract Palladium catalyzed asymmetric allylic alkylations of a bis(trimethylsilyl) substituted propenyl acetate and carbonate were investigated using various chiral ligands and reaction conditions. The best enantioselectivity (86% e.e.) was obtained with the substrate 1-phenyl-3,3-bis(trimethylsilyl)propenyl carbonate 13 and the chiral oxazoline ligand 4c.