Eikichi Wakamatsu

Werner's syndrome as "hyaluronuria".

Abstract Although excretion of acid glycosaminoglycans into urine of five patients with Werners syndrome were within normal limits, the quantity of hyaluronic acid increased in this disease. To this novel finding, a term “Hyaluronuria” was proposed.

Hyaluronuria in a Case of Progeria (Hutchinson-Gilford Syndrome)

A classic case of progeria (Hutchinson‐Gilford syndrome) in a 9‐year‐old Japanese boy is presented. The characteristic clinical features in this patient were similar to those reported in the literature. The total amount of acid glycosaminoglycans excreted in the urine was within the normal range, but there was an increase in hyaluronic acid excretion. The hyaluronuria was a novel finding in progeria, providing a common linkage with the hyaluronuria found in Werners syndrome.

Histomorphometric study of trabecular channels in normal iliac bone

SummaryCancellous bone channels in the normal iliac crest have been studied histologically and by histomorphometry, and their biological role has been considered. Eighty percent of trabecular channels were typical osteons with the same structural and remodeling features as cortical osteons. The similarity of osteons in these two locations was corroborated by the comparability of morphometric features. The points of difference between osteons in the two types of bone were irregular configurations of trabecular osteons and marrow cells in the central canal in some. Since the number of trabecular osteons decreases with age, and since active trabecular resorption cavities were few in number, it is unlikely that additional osteons are formed in normal bone after the active modeling phase of bone growth. It is improbable that they make a significant contribution to bone remodeling since their number decreases with age, and since the available surface of trabecular channels for remodeling is extremely small. However, it is probable that they aid the intraosseous microcirculation and mineral exchange in thick trabecula and bifurcations, where they are mainly located. The demarcation curves at the 95% confidence interval, which suggest the normal range for numbers of channels, was calculated from the scatter diagram against bone area.

Postmortem Study of a Case of Werner's Syndrome

ABSTRACT: The postmortem study of a classic case of Werners syndrome is presented. The subject was a Japanese man who died at the age of 39. Major findings included general microsplanchnia, extreme atrophy of the testes and skin, calcified aortic atherosclerosis, an increase of basophils in the pituitary, aspiration pneumonia, chronic pyelonephritis and a meningioma in the occipital area of the brain. Histologically, no osteoporosis was evident in the lumbar spine and iliac bone. The findings suggest that in Werners syndrome the dominant pathologic factor may be found in connective tissue other than bone.