Elisabeth Andree Schmittling

Selective desilylation of tert-butyldimethylsilyl ethers of phenols using potassium fluoride-alumina and ultrasound

The use of potassium fluoride on basic alumina in acetonitrile with ultrasound for the selecting deprotection of tert-butyldimethylsilyl ethers of phenols is described. The method, which features a non-aqueous work-up, readily cleaves tert-butyldimethylsilyl ethers of phenols at room temperature, whereas tert-butyldimethylsilyl ethers of benzyl alcohols or 2-(trimethylsilyl)ethoxymethyl ethers of phenols are stable.

Structural analogues of LY292728, a highly potent xanthone dicarboxylic acid leukotriene B4 receptor antagonist: spatial positioning of the secondary acid group

Abstract We report the preparation and pharmacologic activity of three spatial analogues of LY292728, a highly potent xanthone dicarboxylic LTB4 receptor antagonist. Molecular modeling of these compounds has helped to further elucidate the nature of the secondary acid binding site of the LTB4 receptor.