Elsa F. Jahn

Genetic Drift in a Religious Isolate: An Analysis of the Causes of Variation in Blood Group and Other Gene Frequencies in a Small Population

The Baltimore Rh Typing Laboratory, The Johns Hopkins University, and The University of Maryland By general recognition race is now increasingly defined in terms of differing gene frequencies, and the origin of such differences has become of very great interest. Sewall Wright, in a notable series of papers (1931, 1932, 1940, 1943, 1948) has developed the theoretical aspects of the interaction of the four factors which can upset existing gene frequency equilibria and establish new gene frequencies, namely, mutation, selection, migration, and genetic drift. In particular, he has pointed out the limitation upon the effectiveness of mutation, migration, and selection pressure in those populations wherein 4Nv, 4Nm, or 4Ns, respectively, are less than 1 (N = effective size of the population; v = mutation rate; m = net migration rate;

ISOSENSITIZATION TO A NEW BLOOD FACTOR, RhD, WITH SPECIAL REFERENCE TO ITS CLINICAL IMPORTANCE

Excerpt Immediately following the announcement of the discovery of the Rh factor by Landsteiner and Wiener1two decades ago came the demonstration of the role of Rh sensitization in the causation of...