Milton S. Sacks

Genetic Drift in a Religious Isolate: An Analysis of the Causes of Variation in Blood Group and Other Gene Frequencies in a Small Population

The Baltimore Rh Typing Laboratory, The Johns Hopkins University, and The University of Maryland By general recognition race is now increasingly defined in terms of differing gene frequencies, and the origin of such differences has become of very great interest. Sewall Wright, in a notable series of papers (1931, 1932, 1940, 1943, 1948) has developed the theoretical aspects of the interaction of the four factors which can upset existing gene frequency equilibria and establish new gene frequencies, namely, mutation, selection, migration, and genetic drift. In particular, he has pointed out the limitation upon the effectiveness of mutation, migration, and selection pressure in those populations wherein 4Nv, 4Nm, or 4Ns, respectively, are less than 1 (N = effective size of the population; v = mutation rate; m = net migration rate;

JUVENILE PERNICIOUS ANEMIA.

THE occasional occurrence of megaloblastic anemia in early childhood was recognized at least thirty years ago, but the relative rarity of cases and the paucity of knowledge of their pathogenesis pr...

ISOSENSITIZATION TO A NEW BLOOD FACTOR, RhD, WITH SPECIAL REFERENCE TO ITS CLINICAL IMPORTANCE

Excerpt Immediately following the announcement of the discovery of the Rh factor by Landsteiner and Wiener1two decades ago came the demonstration of the role of Rh sensitization in the causation of...

THE RESPONSE OF ACUTE LEUKEMIA TO THE ADMINISTRATION OF THE FOLIC ACID ANTAGONISTS, AMINOPTERIN AND AMETHOPTERIN: REPORT OF 14 CASES

Excerpt INTRODUCTION In June 1948 Farber et al.1presented a preliminary report on the therapy of acute leukemia in children, with the folic acid antagonist, aminopterin, 4-amino pteroylglutamic aci...

ION EXCHANGE RESINS

Process Economics Program Report No. 124 ION EXCHANGE RESINS (December 1979) Menlo Park, California 94025 Ion exchange resins are produced in most major industrial countries of the world and are widely used for water treatment, chemical processing, sugar refining , and for many other purposes. The most commonly used synthetic ion exchange resins are made from a copolymer of styrene and divinylbenzene. This report presents technical and economic evaluations for the manufacture of typical ion exchange resins. It includes estimates of the world production capacities for all major kinds of resins, relative amounts of the various functional types produced, and consumption patterns for the United States and Europe. Detailed process descriptions and cost estimates are presented for anion and cation resins based on poly(styrene-divinylbenzene) and on acrylic resins.

THE PROBLEM OF LEPTOSPIROSIS

Excerpt The prevalence of leptospiral infections is probably less fully appreciated by the medical profession of this country than in other parts of the world, particularly Europe. Yet competent in...

ACTH, CORTISONE AND HYPERSENSITIVE DISEASE STATES

Excerpt Recent studies with ACTH and cortisone have demonstrated remarkable, albeit often transitory, effects of these hormones upon a large group of diseases of known hypersensitive etiology. Thes...

SARCOIDOSIS: RANDOM OBSERVATIONS

Excerpt The publication of several recent surveys1, 2, 3of large groups of cases of sarcoidosis, either personally observed or collected from the literature, makes it possible now for the clinician...

VITAMIN B12 AND MEGALOBLASTIC ANEMIA: RECENT STUDIES

Excerpt Since 1948 three substances have been available to the clinician for the treatment of megaloblastic anemias. These three, all members of the vitamin B complex, are folic acid, citrovorum fa...

Lipids and atherosclerosis.

Excerpt Although some 40 years have elapsed since Windaus1reported the predominance of cholesterol and its esters in human atherosclerotic lesions and Anitschkow2produced experimental atheroscleros...