Emilio Soria Olivas

Use of neural networks for dosage individualisation of erythropoietin in patients with secondary anemia to chronic renal failure

The external administration of recombinant human erythropoietin is the chosen treatment for those patients with secondary anemia due to chronic renal failure undergoing periodic hemodialysis. The goal is to carry out an individualised prediction of the erythropoietin dosage to be administered. It is justified because of the high cost of this medication, its secondary effects and the phenomenon of potential resistance which some individuals suffer. One hundred and ten patients were included in this study and several factors were collected in order to develop the neural models. Since the results obtained were excellent, an easy-to-use decision-aid computer application was implemented.

Handbook Of Research On Machine Learning Applications and Trends: Algorithms, Methods and Techniques - 2 Volumes

In many physical, statistical, biological and other investigations it is desirable to approximate a system of points by objects of lower dimension and/or complexity. For this purpose, Karl Pearson invented principal component analysis in 1901 and found ‘lines and planes of closest fit to system of points’. The famous k-means algorithm solves the approximation problem too, but by finite sets instead of lines and planes. This chapter gives a brief practical introduction into the methods of construction of general principal objects, i.e. objects embedded in the ‘middle’ of the multidimensional data set. As a basis, the unifying framework of mean squared distance approximation of finite datasets is selected. Principal graphs and manifolds are constructed as generalisations of principal components and kmeans principal points. For this purpose, the family of expectation/maximisation algorithms with nearest generalisations is presented. Construction of principal graphs with controlled complexity is based on the graph grammar approach.The machine learning approach provides a useful tool when the amount of data is very large and a model is not available to explain the generation and relation of the data set. The Handbook of Research on Machine Learning Applications and Trends: Algorithms, Methods, and Techniques provides a set of practical applications for solving problems and applying various techniques in automatic data extraction and setting. A defining collection of field advancements, this Handbook of Research fills the gap between theory and practice, providing a strong reference for academicians, researchers, and practitioners.

MATLAB-based educational software for exploratory data analysis (EDA toolkit)

This article presents an educational software developed in order to enable engineering students to gain insight into data sets via the exploratory data analysis (EDA). This software has been developed using the MATLAB GUIDE tool. This article shows the program suitability for learning EDA in different engineering courses related to data analysis such as data mining or data processing courses.