Emin Yener Gultekin

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

To clarify the significance of microvessel density (MVD) in a retrospective investigation the relationship between the pattern of MVD (reflecting angiogenesis), and tumour stage, grade, size, and occurrence of microvessel invasion (MVI), metastasis, and cancer‐specific survival (CSS) in patients who had surgery for renal cell carcinoma (RCC).

Prognostic value of the expression of Ki-67, CD44 and vascular endothelial growth factor, and microvessel invasion, in renal cell carcinoma

To determine if use of cell proliferation, cell adhesion, level of angiogenesis‐related factors and presence of microscopic vascular invasion (MVI) could better predict the biological behaviour of renal cell carcinoma (RCC), which has a widely variable clinical outcome despite the use of conventional prognostic factors (staging and grading).

Urinary nuclear matrix protein 22 for diagnosis of renal cell carcinoma

Objective To determine the incidence of positive urinary nuclear matrix protein 22 (NMP22) values, which are currently used to detect transitional cell carcinoma of the bladder, in renal cell carcinoma (RCC). Material and methods Urinary NMP22 values were determined preoperatively in 41 patients in whom a solid renal mass had been detected using CT and who were scheduled for radical nephrectomy; 38 of these patients were diagnosed with RCC. Two patients had xanthogranulomatous pyelonephritis and one had metastasis of a small cell adenocarcinoma to the kidney; these patients were excluded from the study. A total of 30 patients with kidney stones and simple renal cysts were used as controls. Results The urinary NMP22 values of the RCC patients were significantly higher than those of the controls. Of the 38 patients with RCC, 23 (60.5%) had positive urinary NMP22 values ≥10 U/ml. There were four measurements above this cut-off level in the control group. Urinary NMP22 values increased with an increase in pathologic tumor stage, but the correlation was not statistically significant. There was no correlation between grade and urinary NMP22 or between tumor burden and urinary NMP22. Conclusions The urinary NMP22 test may help to diagnose RCC and may also result in an increase in the incidental discovery of RCC. As elevated urinary NMP22 levels have also been found to occur in RCC, patients with suspected bladder cancer and positive urinary NMP22 levels should be more broadly evaluated. Specific NMP assays for renal tumor cells may increase the utility of the test for RCC.

K-Ras mutation in transitional cell carcinoma of urinary bladder

In the present study it was aimed to investigate the frequency of K-RAS mutation in the human bladder transitional cell carcinoma. For thispurpose, tissue specimens obtained from the patients with bladder tumors.Genomic DNAs were isolated and then PCR-SSCP analysis of K-RAS genewere performed. A heterozygous deleted mutation was detected in K-RAS oncogene (exon 2) in agorose gel electrophoresis in one patient andpoint or substitution mutations are detected using single strandconformational polymorphism (SSCP) in other different patients withbladder cancer (4/14). In conclusion, the frequency of K-RAS mutationis not rare and the role of this mutation in oncogenesis and in infiltrationof the urinary bladder wall needs to be confirmed in a larger study.

Adenomatoid tumors of testis and epididymis: a report of two cases.

Adenomatoid tumors are rare benign tumors of female and male genital tracts. In this paper, we reported an epididymal and a testicular adenomatoid tumor in two patients presented with enlarged intrascrotal mass.

Isolated renal and retroperitoneal hydatid cysts: a report of 23 cases.

Isolated extrarenal retroperitoneal and renal echinococcal cysts are rare manifestations of hydatid disease. We report 23 cases of renal and other retroperitoneal hydatid cysts diagnosed and treated in our clinic. Flank pain, abdominal mass and non-specific symptoms such as nausea and vomiting were the major symptoms. Indirect haemagglutination test was positive in 18 cases and eosinophilia in four cases. Among imaging studies computerized tomography was the most valuable diagnostic examination. A high index of suspicion is needed for preoperative diagnosis of hydatid disease of kidney and retroperitoneum.

Penile strangulation injuries

Penile tourniquet injury is probably not a rare entity. Various objects can cause penile strangulation, which may lead to severe injury. Three penile strangulation injuries are presented, one due to thread and two to hair. There were urethral fistulas in two cases. All patients were circumcised and had enuresis nocturna. They were treated successfully. In enuretic patients, it should be kept in mind that there may be a strangulation that can cause penile edema or ulceration and even a urethral fistula.

An unusual cause of incontinence: urethral coitus.

Megalourethra and incontinence due to urethral coitus are very rare phenomena in women. In this paper, we report two cases of urinary incontinence due to urethral coitus where there was no vaginal anomaly or dysfunction.Megalourethra and incontinence due to urethral coitus are very rare phenomena in women. In this paper, we report two cases of urinary incontinence due to urethral coitus where there was no vaginal anomaly or dysfunction.

Epidermoid cyst in the renal pelvis.

Epidermoid cysts are benign cysts localizingrarely in solid organs with an unclearpathogenesis. A 55 years old woman having anepidermoid cyst in the renal pelvis wasevaluated according to the literature.

Effect of Insulin Therapy for Diabetic Cystopathy: Urodynamic and Histological Findings in a Rabbit Model

OBJECTIVE To investigate the efficacy of insulin therapy in preventing cystopathic changes in diabetes using a rabbit model. MATERIALS AND METHODS Twenty-four New Zealand white rabbits were studied in three groups: eight in group 1 as control, eight in group 2 with diabetes by administration intravenously alloxan hydrochloride and eight in group 3 administered insulin therapy after induction of diabetes. Urodynamic investigations were carried out in three groups at the end of 8 weeks. Tissue sections prepared from all groups were studied histologically. RESULTS Bladder capacity and compliance increased in diabetic non-treated group. There was no significant difference between the control group and the diabetic group treated with insulin. The neuropathic changes were observed in the diabetic group, whereas the findings of the histological study were similar in the control and in the insulin treatment group. CONCLUSIONS This animal model indicates that insulin therapy can prevent or delay urodynamic and histopathological changes in diabetes mellitus. These results must be supported by in vitro pharmacological studies.