Gokce Dundar
Cumhuriyet University
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Featured researches published by Gokce Dundar.
Archivio Italiano di Urologia e Andrologia | 2014
Yasin Erden; Esat Korgali; Gokce Dundar; Semih Ayan; Gokhan Gokce; Sahin Yildirim; Emin Yener Gultekin
OBJECTIVE Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and decreased nitric oxide bioactivity in cavernosal tissue. The role of nitric oxide on erectile function is well known. Statins have lipid lowering properties and can modulate endothelial nitric oxide bioavailability. Sildenafil, enhances smooth muscle relaxation in corpus cavernosum. We investigated in-vitro effects of sildenafil and rosuvastatin on nonadrenergic, non-cholinergic and nitric oxide mediated cavernosal smooth muscle relaxation in metabolic syndrome rabbits, since alterations in this pathway are recognised in diabetic and hypercholesterolemic erectile dysfunction. METHODS Ten male rabbits were fed a standard diet as control group, fourty male rabbits were fed a hypercholesterolemic diet for 12 weeks. Hypercholesterolemic group were divided for without treatment, rosuvastatin treatment, sildenafil treatment, and rosuvastatin + sildenafil treatment (N = 10 per groups). RESULTS Serum levels of cholesterol and glucose were significantly higher in the experimental group than in the control group (p < 0.05). After therapy no differences were found among the groups in relaxation responses to sodium nitroprusside. The relaxation responses to carbachol and EFS were significantly reduced in metabolic syndrome group to control group (p < 0.05), but there were no differences between the other groups and control group. There was a significantly lower in-vitro relaxation response in the metabolic syndrome rabbits than in controls and the others (p < 0.05). CONCLUSION Both agents improve in-vitro relaxation responses of erectile tissue from metabolic syndrome rabbits to endothelial non-adrenergic, non-cholinergic and nitric oxide. This finding supports to the results of other clinical studies with these drugs.
Urology Journal | 2018
Gokce Dundar; Kaan Gokcen; Gokhan Gokce; Emin Yener Gultekin
PURPOSE Insufficient alleviation of pain after percutaneous nephrolithotomy causes patient dissatisfaction and generates additional morbidity factors by preventing early mobilization. This study investigated the effects of bupivacaine infiltration with two different doses around the nephrostomy tract after percutaneous nephrolithotomy. MATERIALS AND METHODS Patients who underwent subcostal single entrance percutaneous nephrolithotomy were randomly divided into 3 groups of 20 patients. While the first and second group were planned to receive bupivacaine at rates of 0.5% and 0.25% respectively, the third group was planned to receive a placebo agent to preserve the doubly blinded nature of the study. RESULTS A statistically significant difference was found in the number of patients using tramadole. The frequency of analgesic administration was found lower in the two groups that received bupivacaine in comparison to the group that did not, while the time of the first analgesic administration in the group that received high dose bupivacaine was significantly later than the other groups. Although there was no difference between the groups in terms of total amount of analgesic usage, patients who received higher concentrations of bupivacaine were likely to requirea lower amount of narcotic agent. The frequency of analgesic administration decreased significantly in patients of both groups that received bupivacaine. Moreover, by administering bupivacaine at a 0.5% rate, fewer patients (50%) required narcotic analgesia and the first time of analgesic administration was found to be significantly later. CONCLUSION Administering bupivacaine at a 0.5% rate around the nephrostomy tract after surgery was demonstrated to be more effective.
Case reports in urology | 2014
Esat Korgali; Gokce Dundar; Gokhan Gokce; Fatih Kilicli; Sahande Elagoz; Semih Ayan; Emin Yener Gultekin
Pheochromocytoma is a rare and usually benign neuroendocrine neoplasm. Only 10% of all these tumors are malignant and there are no definitive histological or cytological criteria of malignancy. Single malignancy criteria are the presence of advanced locoregional disease or metastases. We report a case, with a giant retroperitoneal tumor having multiple metastases including palpable rib metastases, who was diagnosed as a malignant pheochromocytoma. The patient was treated with surgery. The literature was reviewed to evaluate tumor features and current diagnostic and therapeutic approaches for patients with metastatic or potentially malignant pheochromocytoma.
Urology Journal | 2016
Gokce Dundar; Gokhan Gokce; Kaan Gokcen; Esat Korgali; Aydemir Asdemir; Kenan Kaygusuz
International Scholarly Research Notices | 2014
Esat Korgali; Gokce Dundar; Kübra Açıkalın Coşkun; Melih Akyol; Yusuf Tutar; Semih Ayan; Gokhan Gokce; Emin Yener Gultekin
Journal of Research in Medical Sciences | 2018
Kaan Gokcen; Gokce Dundar; Halil Gulbahar; Gokhan Gokce; Emin Yener Gultekin
International Braz J Urol | 2018
Kaan Gokcen; Gokce Dundar; Gokhan Gokce; Emin Yener Gultekin
International Braz J Urol | 2018
Kaan Gokcen; Gokhan Gokce; Gokce Dundar; resul çiçek; Halil Gulbahar; Emin Yener Gultekin
Üroonkoloji Bülteni | 2016
Gokce Dundar; Esat Korgali
ics.org | 2016
Esat Korgali; Gokce Dundar