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Emma Budd

Novartis

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Publication

Featured researches published by Emma Budd.

Bioorganic & Medicinal Chemistry Letters | 2012

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Ian Bruce; Mohammed Akhlaq; Graham Charles Bloomfield; Emma Budd; Brian Cox; Bernard Cuenoud; Peter Finan; Peter Gedeck; Julia Hatto; Judy Hayler; Denise Head; Thomas H. Keller; Louise Kirman; Catherine Leblanc; Darren Le Grand; Clive Mccarthy; Desmond O’Connor; Charles Owen; Mrinalini Sachin Oza; Gaynor Elizabeth Pilgrim; Nicola Press; Lilya Sviridenko; Lewis Whitehead

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

Archive | 2004

Inhibitors of phosphatidylinositol 3-kinase

Ian Bruce; Bernard Cuenoud; Thomas H. Keller; Gaynor Elizabeth Pilgrim; Nicola Press; Grand Darren Mark Le; Cathy Ritchie; Barbara Valade; Judy Hayler; Emma Budd

Archive | 2011

Pyridine and pyrazine derivative for the treatment of CF

Urs Baettig; Kamlesh Jagdis Bala; Emma Budd; Lee Edwards; Catherine Howsham; Glyn Hughes; Darren Mark Legrand; Katrin Spiegel

Archive | 2012

N-substituted heterocyclyl carboxamides

Kamlesh Jagdis Bala; Emma Budd; Lee Edwards; Catherine Howsham; Darren Mark Legrand; Roger John Taylor

Archive | 2007

5-PHENYL-THIAZOL-2-YL-UREA DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

Emma Budd; Judy Hayler; Ian Bruce; Darren Mark Legrand; Brian Cox

Archive | 2008

Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel

Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith

Archive | 2007

5-PHENYL-THIAZ0L-2-YL-UREA DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

Emma Budd; Judy Hayler; Ian Bruce; Darren Mark Legrand; Brian Cox

Archive | 2009

PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K

Ian Bruce; Emma Budd; Lee Edwards; Catherine Howsham

Archive | 2009

Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme

Ian Bruce; Emma Budd; Lee Edwards; Catherine Howsham

Archive | 2014

Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives

Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith

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Catherine Howsham

Novartis

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Lee Edwards

Novartis

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Graham Charles Bloomfield

Novartis

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Ian Bruce

Novartis

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Peter Gedeck

Novartis

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Andrew Dunstan

Novartis

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Gurdip Bhalay

Novartis

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Peter Hunt

Novartis

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Stephen Paul Collingwood

Novartis

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Thomas Anthony Hunt

Novartis

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