Thomas Anthony Hunt
Novartis
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Publication
Featured researches published by Thomas Anthony Hunt.
Bioorganic & Medicinal Chemistry Letters | 2012
Thomas Anthony Hunt; Hazel C. Atherton-Watson; Jake Axford; Stephen Paul Collingwood; Kevin Coote; Brian Cox; Sarah Czarnecki; Henry Danahay; Nicholas James Devereux; Catherine Howsham; Peter Hunt; Victoria Paddock; Derek Paisley; Alice Young
We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational design hypothesis a series of quaternary amines were prepared and evaluated for their ability to block ion transport via ENaC in human bronchial epithelial cells (HBECs). Compound 11 has an IC(50) of 200nM and is efficacious in the Guinea-pig tracheal potential difference (TPD) model of ENaC blockade with an ED(50) of 44μgkg(-1) at 1h. As such, pyrazinoyl quaternary amines represent the first examples of a promising new class of human ENaC blockers.
Archive | 2008
Ian Bruce; James Dale; Thomas Anthony Hunt
Archive | 2009
Stephen Paul Collingwood; Catherine Howsham; Thomas Anthony Hunt
Archive | 2012
John Tellew; Xia Wang; Yongqin Wan; Yun Feng Xie; Shifeng Pan; Jiqing Jiang; Yongping Xie; Thomas Anthony Hunt; Lee Edwards; David Beattie; Mark Patrick Healy; Ryan West; Andrew Stuart Lister
Pharmaceutical patent analyst | 2015
Rebecca Butler; Thomas Anthony Hunt; Nichola Smith
Archive | 2008
Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith
Archive | 2014
Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith
Archive | 2009
Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt
Archive | 2008
Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith
Archive | 2008
Gurdip Bhalay; Emma Budd; Graham Charles Bloomfield; Stephen Paul Collingwood; Andrew Dunstan; Lee Edwards; Peter Gedeck; Catherine Howsham; Peter Hunt; Thomas Anthony Hunt; Paul Oakley; Nichola Smith
