Emmanuel Klein
Centre national de la recherche scientifique
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Featured researches published by Emmanuel Klein.
Tetrahedron | 2001
Thierry Brossette; Emmanuel Klein; Christophe Créminon; Jacques Grassi; Charles Mioskowski; Luc Lebeau
Abstract A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5′- O -monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier.
Chemistry: A European Journal | 2002
Emmanuel Klein; Hoàng-Oanh Nghiêm; Alain Valleix; Charles Mioskowski; Luc Lebeau
Thiamine (vitamin B1) is an essential nutritional factor metabolized inside the body in its mono-, di-, and triphosphate forms. Although the action of thiamine and thiamine diphosphate have been intensely investigated, many questions remain unanswered and the role of thiamine triphosphate is still especially unknown. To probe recent hypotheses on the implication of thiamine triphosphate in a new phosphorylation pathway involving synaptic proteins, we synthesized a series of thiamine di- and triphosphate analogues that are resistant to both enzymatic and chemical hydrolyses. The key step in the preparation of the title compounds is the coupling of thiamine propyl disulfide with adequately protected methylenebis-phosphonic acid, the corresponding triphosphate analogue, and difluoromethylenebisphosphonic acid.
Tetrahedron Letters | 2001
Stéphane Mons; Emmanuel Klein; Charles Mioskowski; Luc Lebeau
Abstract A new route to bis-methylene analogs of triphosphate esters involving carbanion chemistry is described. Lithiated methaneselenophosphonate anion is condensed several times with chlorophosphites and phosphoramidous chlorides prior to esterification/transesterification and selenation or oxidation.
Tetrahedron Letters | 2001
Stéphane Mons; Nicolas Sabourault; Emmanuel Klein; Charles Mioskowski; Luc Lebeau
Abstract α-Chlorination of phosphonates, and O,O -dialkyl thio- and selenophosphonates involving the direct reaction of their lithiated anion with phosphorus oxychloride is described. The reaction gives good results where previously known methods fail. The role of the chalcogen atom, and the influence of the nature of the alkyl chain with respect to the reactivity are discussed.
Synthetic Communications | 2010
Clémentine Féau; Emmanuel Klein; Paul Kerth; Luc Lebeau
A series of 14 new 3-alkoxycarbonyl 6-aza-, 7-aza-, and 6,8-diaza-coumarins was prepared using various strategies involving either a Knoevenagel or a Pechmann condensation reaction. The coumarin nucleus displays different reactive functional groups allowing straightforward derivatization. The optical properties of the new azacoumarins were measured in methanol.
Bioorganic & Medicinal Chemistry | 2007
Emmanuel Klein; Salvatore DeBonis; Bernd Thiede; Dimitrios A. Skoufias; Frank Kozielski; Luc Lebeau
Bioconjugate Chemistry | 2010
Emmanuel Klein; Miahala Ciobanu; Jérôme Klein; Valérie Machi; Christian Leborgne; Thierry F. Vandamme; Benoı̂t Frisch; Françoise Pons; Antoine Kichler; Guy Zuber; Luc Lebeau
Bioorganic & Medicinal Chemistry Letters | 2007
Clémentine Féau; Emmanuel Klein; Paul Kerth; Luc Lebeau
Biomaterials | 2008
Emmanuel Klein; Paul Kerth; Luc Lebeau
Organic and Biomolecular Chemistry | 2009
Clémentine Féau; Emmanuel Klein; Carsten Dosche; Paul Kerth; Luc Lebeau