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Dive into the research topics where Emmanuel Klein is active.

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Featured researches published by Emmanuel Klein.


Tetrahedron | 2001

Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides

Thierry Brossette; Emmanuel Klein; Christophe Créminon; Jacques Grassi; Charles Mioskowski; Luc Lebeau

Abstract A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5′- O -monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier.


Chemistry: A European Journal | 2002

Synthesis of Stable Analogues of Thiamine Di‐ and Triphosphate as Tools for Probing a New Phosphorylation Pathway

Emmanuel Klein; Hoàng-Oanh Nghiêm; Alain Valleix; Charles Mioskowski; Luc Lebeau

Thiamine (vitamin B1) is an essential nutritional factor metabolized inside the body in its mono-, di-, and triphosphate forms. Although the action of thiamine and thiamine diphosphate have been intensely investigated, many questions remain unanswered and the role of thiamine triphosphate is still especially unknown. To probe recent hypotheses on the implication of thiamine triphosphate in a new phosphorylation pathway involving synaptic proteins, we synthesized a series of thiamine di- and triphosphate analogues that are resistant to both enzymatic and chemical hydrolyses. The key step in the preparation of the title compounds is the coupling of thiamine propyl disulfide with adequately protected methylenebis-phosphonic acid, the corresponding triphosphate analogue, and difluoromethylenebisphosphonic acid.


Tetrahedron Letters | 2001

Selenophosphonates as building blocks for the preparation of bis-methylene analogs of triphosphates

Stéphane Mons; Emmanuel Klein; Charles Mioskowski; Luc Lebeau

Abstract A new route to bis-methylene analogs of triphosphate esters involving carbanion chemistry is described. Lithiated methaneselenophosphonate anion is condensed several times with chlorophosphites and phosphoramidous chlorides prior to esterification/transesterification and selenation or oxidation.


Tetrahedron Letters | 2001

Direct α-chlorination of O,O-dialkyl chalcogenophosphonates with phosphorus oxychloride

Stéphane Mons; Nicolas Sabourault; Emmanuel Klein; Charles Mioskowski; Luc Lebeau

Abstract α-Chlorination of phosphonates, and O,O -dialkyl thio- and selenophosphonates involving the direct reaction of their lithiated anion with phosphorus oxychloride is described. The reaction gives good results where previously known methods fail. The role of the chalcogen atom, and the influence of the nature of the alkyl chain with respect to the reactivity are discussed.


Synthetic Communications | 2010

Preparation and Optical Properties of Novel 3-Alkoxycarbonyl Aza- and Diazacoumarins

Clémentine Féau; Emmanuel Klein; Paul Kerth; Luc Lebeau

A series of 14 new 3-alkoxycarbonyl 6-aza-, 7-aza-, and 6,8-diaza-coumarins was prepared using various strategies involving either a Knoevenagel or a Pechmann condensation reaction. The coumarin nucleus displays different reactive functional groups allowing straightforward derivatization. The optical properties of the new azacoumarins were measured in methanol.


Bioorganic & Medicinal Chemistry | 2007

New chemical tools for investigating human mitotic kinesin Eg5

Emmanuel Klein; Salvatore DeBonis; Bernd Thiede; Dimitrios A. Skoufias; Frank Kozielski; Luc Lebeau


Bioconjugate Chemistry | 2010

HFP Fluorinated Cationic Lipids for Enhanced Lipoplex Stability and Gene Delivery

Emmanuel Klein; Miahala Ciobanu; Jérôme Klein; Valérie Machi; Christian Leborgne; Thierry F. Vandamme; Benoı̂t Frisch; Françoise Pons; Antoine Kichler; Guy Zuber; Luc Lebeau


Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis of a coumarin-based europium complex for bioanalyte labeling.

Clémentine Féau; Emmanuel Klein; Paul Kerth; Luc Lebeau


Biomaterials | 2008

Enhanced selective immobilization of biomolecules onto solid supports coated with semifluorinated self-assembled monolayers.

Emmanuel Klein; Paul Kerth; Luc Lebeau


Organic and Biomolecular Chemistry | 2009

Synthesis and characterization of coumarin-based europium complexes and luminescence measurements in aqueous media

Clémentine Féau; Emmanuel Klein; Carsten Dosche; Paul Kerth; Luc Lebeau

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Luc Lebeau

Centre national de la recherche scientifique

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Charles Mioskowski

Centre national de la recherche scientifique

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Clémentine Féau

Centre national de la recherche scientifique

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Stéphane Mons

Centre national de la recherche scientifique

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Alain Valleix

Centre national de la recherche scientifique

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Benoı̂t Frisch

Centre national de la recherche scientifique

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Christian Leborgne

Centre national de la recherche scientifique

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Dimitrios A. Skoufias

Centre national de la recherche scientifique

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Nicolas Sabourault

Centre national de la recherche scientifique

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Salvatore DeBonis

Centre national de la recherche scientifique

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