Enrique Mario Spinelli

AC-coupled front-end for biopotential measurements

AC coupling is essential in biopotential measurements. Electrode offset potentials can be several orders of magnitude larger than the amplitudes of the biological signals of interest, thus limiting the admissible gain of a dc-coupled front end to prevent amplifier saturation. A high-gain input stage needs ac input coupling. This can be achieved by series capacitors, but in order to provide a bias path, grounded resistors are usually included, which degrade the common mode rejection ratio (CMRR). This paper proposes a novel balanced input ac-coupling network that provides a bias path without any connection to ground, thus resulting in a high CMRR. The circuit being passive, it does not limit the differential dc input voltage. Furthermore, differential signals are ac coupled, whereas common-mode voltages are dc coupled, thus allowing the closed-loop control of the dc common mode voltage by means of a driven-right-leg circuit. This makes the circuit compatible with common-mode dc shifting strategies intended for single-supply biopotential amplifiers. The proposed circuit allows the implementation of high-gain biopotential amplifiers with a reduced number of parts, thus resulting in low power consumption. An electrocardiogram amplifier built according to the proposed design achieves a CMRR of 123 dB at 50 Hz.

Insulating electrodes: a review on biopotential front ends for dielectric skin–electrode interfaces

Insulating electrodes, also known as capacitive electrodes, allow acquiring biopotentials without galvanic contact with the body. They operate with displacement currents instead of real charge currents, and the electrolytic electrode-skin interface is replaced by a dielectric film. The use of insulating electrodes is not the end of electrode interface problems but the beginning of new ones: coupling capacitances are of the order of pF calling for ultra-high input impedance amplifiers and careful biasing, guarding and shielding techniques. In this work, the general requirements of front ends for capacitive electrodes are presented and the different contributions to the overall noise are discussed and estimated. This analysis yields that noise bounds depend on features of the available devices as current and voltage noise, but the final noise level also depends on parasitic capacitances, requiring a careful shield and printed circuit design. When the dielectric layer is placed on the skin, the present-day amplifiers allow achieving noise levels similar to those provided by wet electrodes. Furthermore, capacitive electrode technology allows acquiring high quality ECG signals through thin clothes. A prototype front end for capacitive electrodes was built and tested. ECG signals were acquired with these electrodes in direct contact with the skin and also through cotton clothes 350 µm thick. They were compared with simultaneously acquired signals by means of wet electrodes and no significant differences were observed between both output signals.

A novel fully differential biopotential amplifier with DC suppression

Fully differential amplifiers yield large differential gains and also high common mode rejection ratio (CMRR), provided they do not include any unmatched grounded component. In biopotential measurements, however, the admissible gain of amplification stages located before dc suppression is usually limited by electrode offset voltage, which can saturate amplifier outputs. The standard solution is to first convert the differential input voltage to a single-ended voltage and then implement any other required functions, such as dc suppression and dc level restoring. This approach, however, yields a limited CMRR and may result in a relatively large equivalent input noise. This paper describes a novel fully differential biopotential amplifier based on a fully differential dc-suppression circuit that does not rely on any matched passive components, yet provides large CMRR and fast recovery from dc level transients. The proposed solution is particularly convenient for low supply voltage systems. An example implementation, based on standard low-power op amps and a single 5-V power supply, accepts input offset voltages up to /spl plusmn/500 mV, yields a CMRR of 102dB at 50 Hz, and provides, in accordance with the AAMI EC38 standard, a reset behavior for recovering from overloads or artifacts.

A transconductance driven-right-leg circuit

Biopotential measurements are very sensitive to electromagnetic interference (EMI). EMI gets into the acquisition system by many ways, both as differential and common mode signals, driven-right-leg circuits (DRL) are widely used to reduce common mode interference. This paper reports an improvement on the classic DRL. The proposed circuit uses a transconductance amplifier to drive the patients body. This configuration has some interesting properties, which provide an extended bandwidth for high-frequency EMI rejection (such as fluorescent lights interference). The improvement is around 20 dB for frequencies of few kilohertz and the circuit is easy to compensate for stability. A comparative analysis against a typical DRL is presented, the results obtained have been experimentally tested.

Two-electrode biopotential measurements: power line interference analysis

In this paper, an analysis of power line interference in two-electrode biopotential measurement amplifiers is presented. A model of the amplifier that includes its input stage and takes into account the effects of the common mode input impedance Z/sub C/ is proposed. This approach is valid for high Z/sub C/ values, and also for some recently proposed low-Z/sub C/ strategies. It is shown that power line interference rejection becomes minimal for extreme Z/sub C/ values (null or infinite), depending on the electrode-skin impedances unbalance /spl Delta/Z/sub E/. For low /spl Delta/Z/sub E/ values, minimal interference is achieved by a low Z/sub C/ strategy (Z/sub C/=0), while for high /spl Delta/Z/sub E/ values a very high Z/sub C/ is required. A critical /spl Delta/Z/sub E/ is defined to select the best choice, as a function of the amplifiers Common Mode Rejection Ratio (CMRR) and stray coupling capacitances. Conclusions are verified experimentally using a biopotential amplifier specially designed for this test.

A single supply biopotential amplifier

A biopotential amplifier for single supply operation is presented. It uses a Driven Right Leg Circuit (DRL) to drive the patients body to a DC common mode voltage, centering biopotential signals with respect to the amplifiers input voltage range. This scheme ensures proper range operation when a single power supply is used. The circuit described is especially suited for low consumption, battery-powered applications, requiring a single battery and avoiding switching voltage inverters to achieve dual supplies. The generic circuit is described and, as an example, a biopotential amplifier with a gain of 60 dB and a DC input range of +/-200 mV was implemented using low power operational amplifiers. A Common Mode Rejection Ratio (CMRR) of 126 dB at 50 Hz was achieved without trimming.

A Multichannel EEG Acquisition Scheme Based on Single Ended Amplifiers and Digital DRL

Single ended (SE) amplifiers allow implementing biopotential front-ends with a reduced number of parts, being well suited for preamplified electrodes or compact EEG headboxes. On the other hand, given that each channel has independent gain; mismatching between these gains results in poor common-mode rejection ratios (CMRRs) (about 30 dB considering 1% tolerance components). This work proposes a scheme for multichannel EEG acquisition systems based on SE amplifiers and a novel digital driven right leg (DDRL) circuit, which overcome the poor CMRR of the front-end stage providing a high common mode reduction at power line frequency (up to 80 dB). A functional prototype was built and tested showing the feasibility of the proposed technique. It provided EEG records with negligible power line interference, even in very aggressive EMI environments.

A practical approach to electrode-skin impedance unbalance measurement

Unbalance between electrode-skin impedances is a major problem in biopotential recordings, leading to increased power-line interference. This paper proposes a simple, direct method to measure that unbalance at power-line frequency (50-60 Hz), thus allowing the determination of actual recording conditions for biopotential amplifiers. The method is useful in research, amplifier testing, electrode design and teaching purposes. It has been experimentally validated by using both phantom impedances and real electrode-skin impedances.

A capacitive electrode with fast recovery feature

Capacitive electrodes (CEs) allow for acquiring biopotentials without galvanic contact, avoiding skin preparation and the use of electrolytic gel. The signal quality provided by present CEs is similar to that of standard wet electrodes, but they are more sensitive to electrostatic charge interference and motion artifacts, mainly when biopotentials are picked up through clothing and coupling capacitances are reduced to tens of picofarads. When artifacts are large enough to saturate the preamplifier, several seconds (up to tens) are needed to recover a proper baseline level, and during this period biopotential signals are irremediably lost. To reduce this problem, a CE that includes a fast-recovery (FR) circuit is proposed. It works directly on the coupling capacitor, recovering the amplifier from saturation while preserving ultra-high input impedance, as a CE requires. A prototype was built and tested acquiring ECG signals. Several experimental data are presented, which show that the proposed circuit significantly reduces record segment losses due to amplifier saturation when working in real environments.

AC coupled three op-amp biopotential amplifier with active DC suppression

A three op-amps instrumentation amplifier (IA) with active DC suppression is presented. DC suppression is achieved by means of a controlled floating source at the input stage, to compensate electrode and op-amps offset voltages. This isolated floating source is built around an optical-isolated device using a general-purpose optocoupler, working as a photovoltaic generator. The proposed circuit has many interesting characteristics regarding simplicity and cost, while preserving common mode rejection ratio (CMRR) and high input impedance characteristics of the classic three op-amps IA. As an example, a biopotential amplifier with a gain of 80 dB, a lower cutoff frequency of 0.1 Hz, and a DC input range of /spl plusmn/8 mV was built and tested. Using general-purpose op-amps, a CMRR of 105 was achieved without trimmings.