Eric Meurville

Design, Realization and Measurements of a Miniature Antenna for Implantable Wireless Communication Systems

The design procedure, realization and measurements of an implantable radiator for telemetry applications are presented. First, free space analysis allows the choice of the antenna typology with reduced computation time. Subsequently the antenna, inserted in a body phantom, is designed to take into account all the necessary electronic components, power supply and bio-compatible insulation so as to realize a complete implantable device. The conformal design has suitable dimensions for subcutaneous implantation (10 × 32.1 mm). The effect of different body phantoms is discussed. The radiator works in both the Medical Device Radiocommunication Service (MedRadio, 401-406 MHz) and the Industrial, Scientific and Medical (ISM, 2.4-2.5 GHz) bands. Simulated maximum gains attain -28.8 and - 18.5 dBi in the two desired frequency ranges, respectively, when the radiator is implanted subcutaneously in a homogenous cylindrical body phantom (80 × 110 mm) with muscle equivalent dielectric properties. Three antennas are realized and characterized in order to improve simulation calibration, electromagnetic performance, and to validate the repeatability of the manufacturing process. Measurements are also presented and a good correspondence with theoretical predictions is registered.

Size-Selective Diffusion in Nanoporous but Flexible Membranes for Glucose Sensors

A series of nanoporous membranes prepared from polyethylene-block-polystyrene were applied for size-selective diffusion of glucose and albumin molecules. Millimeter-sized test cells for characterization of such molecular diffusions were designed assuming an implantable glucose sensor. The prepared nanoporous membrane exhibits excellent flexibility and toughness compared to conventional nanoporous membranes of brittle alumina. Pore size of the membranes could be controlled from 5 to 30 nm by varying preparation conditions. All of these nanoporous membranes prepared in this study let glucose pass through, indicating a continuous pore connection through the entire thickness of the membrane in a few tens of micrometers. In contrast, membranes prepared under optimum conditions could perfectly block albumin permeation. This means that these vital molecules having different sizes can be selectively diffused through the nanoporous membranes. Such a successful combination of size selectivity of molecular diffusion in nanoscale and superior mechanical properties in macroscale is also beneficial for other devices requesting down-sized manufacture.

Implanted antenna for biomedical applications

In this paper we present the design, realization and measurements of a first prototype of a complete implantable device. The RF system, working over the medical implanted communication systems (MICS) bandwidth and composed of the antenna, the battery, the transceiver for the data communication and the insulation material, has been designed and realized in order to be integrated with an implanted glucose sensor.

In-vitro platform to study ultrasound as source for wireless energy transfer and communication for implanted medical devices

A platform to study ultrasound as a source for wireless energy transfer and communication for implanted medical devices is described. A tank is used as a container for a pair of electroacoustic transducers, where a control unit is fixed to one wall of the tank and a transponder can be manually moved in three axes and rotate using a mechanical system. The tank is filled with water to allow acoustic energy and data transfer, and the system is optimized to avoid parasitic effects due to cables, reflection paths and cross talk problems. A printed circuit board is developed to test energy scavenging such that enough acoustic intensity is generated by the control unit to recharge a battery loaded to the transponder. In the same manner, a second printed circuit board is fabricated to study transmission of information through acoustic waves.

A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids.

We present a viscometric affinity biosensor for continuous monitoring of glucose in biological fluids such as blood and plasma. The sensing principle of this chemico-mechanical sensor is based upon the viscosity variation of a sensitive fluid with glucose concentration. Basically, this device includes both an actuating and a sensing piezoelectric diaphragms as well as a flow-resistive microchannel. In order to confine the sensitive fluid and allow glucose diffusion into the sensor, a free-standing alumina nanoporous membrane is also used as size-selective interface. Measurements carried out at nominal temperatures of 25 and 37 °C reveal that this sensor topology exhibits a high resolution in the current range of physiological blood glucose concentrations, i.e. 2-20 mM. In addition, complete reversibility was also demonstrated for at least 3 days. Finally, measurements performed in human blood serum confirm that this sensor fulfils all basic requirements for a use in continuous glucose monitoring of biological fluids.

Instrumented Knee Prosthesis for Force and Kinematics Measurements

In this work, we present the general concept of an instrumented smart knee prosthesis for in-vivo measurement of forces and kinematics. This system can be used for early monitoring of the patient after implantation and prevent possible damage to the prosthesis. The diagnosis of defects can be done by detecting the load imbalance or abnormal forces and kinematics of the prosthetic knee in function. This work is a step towards the fabrication of an instrumented system for monitoring the function of the knee in daily conditions. Studying the constraints of commercially available prostheses, we designed a minimal sensory system and required electronics to be placed in the polyethylene part of prostheses. Three magnetic sensors and a permanent magnet were chosen and configured to measure the prosthetic knee kinematics. Strain gauges were designed to measure the forces applied to the polyethylene insert. Kinematic and force measurements were validated on a mechanical knee simulator by comparing them to different reference systems. Embedded electronics, including the A/D converters and amplifier were designed to acquire and condition the measurements to wirelessly transmit them to an external unit. By considering the necessary power budget for all components, the optimum coil for remote powering was investigated. The necessary rectifier and voltage doubler for remote powering were also designed. This is the first system capable of internally measuring force and kinematics simultaneously. We propose to package the system in the polyethylene part, bringing versatility to the instrumented system developed, as the polyethylene part can be easily modified for different types of prostheses based on the same principle, without changing the prosthesis design.

Instrumented prosthesis for knee implants monitoring

In this work we present an instrumented smart knee prosthesis for in-vivo measurement of forces and kinematics. Studying the constraints, we designed minimal sensory systems to be placed in the polyethylene part of the prosthesis. The magnetic sensors and a permanent magnet are chosen and configured to measure the relative kinematics of the prosthesis. Moreover, the strain gauges were designed to measure the forces on the polyethylene part. The kinematic and kinetic measurements on a mechanical knee simulator are validated toward reference systems. The supplementary electronics, including the A/D, amplifier, rectifier and voltage doubler are designed. Consequently, by considering the necessary power budget for all the components to be performed, the optimal coils for remote powering is investigated. The system will be packaged in the polyethylene part. Therefore, by the end we will have a smart polyethylene part which can be easily modified for different types of the knee prosthesis without changing the prosthesis design.

Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors

A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, a radio frequency communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate. Tests using animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted bio-nano-sensors. These tests confirm that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.

Example of Data Telemetry for Biomedical Applications: An In Vivo Experiment

This letter describes a data telemetry biomedical experiment. An implant, consisting of a biometric data sensor, electronics, an antenna, and a biocompatible capsule, is described. All the elements were co-designed in order to maximize the transmission distance. The device was implanted in a pig for an in vivo experiment of temperature monitoring.

Dual band antenna for subcutaneous telemetry applications

The use of telemetry with implantable medical devices improves the quality of the health-care system facilitating home therapy. For this purpose, small biocompatible antennas are necessary to establish reliable communication systems [1–5]. In this work we present a dual band antenna conceived to operate in vivo in a subcutaneous environment. The selected working frequencies are: the Medical Device Radiocommunication Service band (MedRadio, 401–406 MHz) [6] and the Industrial, Scientific and Medical band (ISM, 2.4–2.5 GHz). This radiator matches the requirements of a MedRadio transceiver produced by Zarlink Semiconductors [7]. The antenna together with its electronics and power supply [8] forms a versatile im-plantable telecommunication system that can be integrated with the desired medical device.