Eric Strobel | Researchain

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Featured researches published by Eric Strobel.

Journal of Medicinal Chemistry | 2017

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

Nicole Cathleen Goodwin; Zhi-Ming Ding; Bryce Alden Harrison; Eric Strobel; Angela L. Harris; Melinda Smith; Andrea Y. Thompson; Wendy Xiong; Faika Mseeh; Debra Bruce; Damaris S. Diaz; Suma Gopinathan; Ling Li; Emily O’Neill; Mary Thiel; Alan Wilson; Kenneth G. Carson; David R. Powell; David B. Rawlins

The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic patents. Herein we report the discovery of LX2761, a locally acting SGLT1 inhibitor that is highly potent in vitro and delays intestinal glucose absorption in vivo to improve glycemic control.

Journal of Organic Chemistry | 2005

Improved solution- and solid-phase preparation of hydroxamic acids from esters

Chih Y. Ho; Eric Strobel; Janet Ralbovsky; Robert A. Galemmo

Journal of Medicinal Chemistry | 2005

(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells

Chih Y. Ho; Donald William Ludovici; Umar Maharoof; Jay Mei; Jan L. Sechler; Robert W. Tuman; Eric Strobel; Laura Andraka; Hwa-Kwo Yen; Gregory C. Leo; Jian Li; Harold R. Almond; Hong Lu; Ann Devine; Rose Tominovich; Judith Baker; Stuart Emanuel; Robert H. Gruninger; Steven A. Middleton; Dana L. Johnson; Robert A. Galemmo

Archive | 2003

N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors

Chih Yung Ho; Bengt Anders Brunmark; Stuart Emanuel; Jr. Robert A. Galemmo; Dana L. Johnson; Donald William Ludovici; Umar Maharoof; Jay M. Mei; Jan L. Sechler; Eric Strobel; Robert W. Tuman; Hwa Kwo Yen

Archive | 2017

inibidores de cotransportador 1 de glicose de sódio

Brian Zambrowicz; Bryce Alden Harrison; David B. Rawlins; Eric Strobel; Kenneth G. Carson; Nicole Cathleen Goodwin

Archive | 2015

INHIBIDORES DEL COTRANSPORTADOR DE SODIO GLUCOSA TIPO 1

Kenneth G. Carson; Nicole Cathleen Goodwin; Bryce Alden Harrison; David B. Rawlins; Eric Strobel; Brian Zambrowicz

Archive | 2013

Inhibiteurs du cotransporteur sodium glucose 1

Kenneth G. Carson; Nicole Cathleen Goodwin; Bryce Alden Harrison; David B. Rawlins; Eric Strobel; Brian Zambrowicz

Cancer Research | 2005

A novel PDGFR kinase, c-ABL and c-Kit inhibitor with unique anti-proliferative activity inducing specific cell cycle dysregulation in human leukemia cells

Jay Mei; Robert Tuman; Hong Lu; Jan L. Sechler; Judith Baker; Thomas Garrabrant; Rose Tominovich; Ann Devine; Chih Ho; Donald Ludovici; Eric Strobel; Robert A. Galemmo; Dana L. Johnson

Archive | 2003

N-substituted tricyclic 3-aminopyrazoles as pdgf receptor inhibitors

Jr. Robert A. Galemmo; Bengt Anders Brunmark; Stuart Emanuel; Chih Yung Ho; Dana L. Johnson; Donald William Ludovici; Umar Maharoof; Jay M. Mei; Jan L. Sechler; Eric Strobel; Robert W. Tuman; Hwa Kwo Yen

Archive | 2003

N-substituierte tricyclische 3-aminopyrazole als pdgf rezeptorenhemmer N-substituted tricyclic 3-aminopyrazoles as PDGF receptors inhibitors

Chih Yung Ho; Bengt Anders Brunmark; Stuart Emanuel; Robert A. Galemmo; Dana L. Johnson; Donald William Ludovici; Umar Maharoof; Jay M. Mei; Jan L. Sechler; Eric Strobel; Robert W. Tuman; Hwa Kwo Yen

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