Erica Rojas Bilbao

Soft tissue metastases from differentiated thyroid cancer diagnosed by 18F FDG PET-CT

Distant metastases of differentiated thyroid cancer are unusual; lung and bones are the most frequently affected sites. Soft tissue metastases (STM) are extremely rare. We describe two cases of patients with differentiated thyroid cancer metastasizing to soft tissues. Both patients had widespread metastatic disease; clinically asymptomatic soft tissue metastases were found by ¹⁸-Fluordeoxyglucose positron emission tomography/computed tomography (¹⁸F FDG PET-CT), and confirmed by cytological and/or histopathological studies. These findings underscore the ability of ¹⁸F FDG PET-CT in accurately assessing the extent of the disease, as well as the utility of the method to evaluate regions of the body that are not routinely explored.

Primary NK/T cell lymphoma nasal type of the colon

Since nasal NK/T-cell lymphoma and NK/T-cell lymphoma nasal type are rare diseases, colonic involvement has seldom been seen. We report a case of a patient with a primary NK/T-cell lymphoma nasal type of the colon. The patient had no history of malignant diseases and was diagnosed after exhaustive study in the context of fever of unknown origin. The first therapeutic approach followed the DA-EPOCH-protocol: etoposide, prednisone, doxor-rubicin, vincristine and cyclophosphamide. The persistence of constitutional symptoms after the first treatment course motivated the switch to a second line following the SMILE-protocol: dexamethasone, metotrexate, ifosfamide, E.coli L-asparaginase, and etoposide. Despite intensive chemotherapy, the patient died 2 months after the diagnose of an extranodal NK/T-cell lymphoma of the colon and 4 months after the first symptomatic appearance of disease.

Estudio de una cohorte de pacientes adultos con tumores primarios de sistema nervioso central de la serie glial

Resumen Introduccion En los ultimos anos se sucedieron cambios en la neurooncologia que mejoraron la calidad de vida y sobrevida de pacientes con tumores primarios (TP) del SNC. Objetivos Presentar las caracteristicas clinicas de una cohorte de pacientes con TP de SNC de la serie glial. Material y metodos Entre los anos 2002-2009 se realizo el seguimiento de 148 pacientes con TP de SNC. Se analizaron solo los tumores de la serie glial intracraneanos. Este es un estudio descriptivo. Resultados Setenta y nueve pacientes (52 varones y 27 mujeres) presentaron tumores de la serie glial. El mayor numero de casos se presentaron en la cuarta decada. Segun la histopatologia: 34 glioblastomas multiformes (GBM), 6 astrocitomas GIII, 9 astrocitomas GII, 5 astrocitomas GI, 3 gliomas de tronco, 1 glioma cordoide, 16 oligodendrogliomas GII y 5 oligodendrogliomas GIII. La localizacion mas frecuente fue en el lobulo frontal. Los sintomas de inicio, en orden de frecuencia, fueron: crisis comiciales, cefalea, afasias, deficits cognitivos, motores o sensitivos, patologia de pares y sindrome de hipertension endocraneana. En 27 pacientes el tratamiento fue quirurgico/radioterapia/quimioterapia (Qx/Rt/Qt), 20 Rt/Qt, 6 Qx, 6 Qt, 5 Rt, 5 Qx/Qt, 4 Qx/Rt, y 6 pacientes no realizaron tratamiento. El 51% de los pacientes tuvieron reseccion parcial o completa del tumor. Las crisis epilepticas (parciales [62%] y generalizadas [38%]) fueron controladas completamente en el 66% de los casos con monoterapia. Conclusiones El GBM fue el tumor mas frecuente y el lobulo frontal el mas comprometido. El sintoma prevalente fueron las crisis epilepticas. Obtuvimos un porcentaje bajo de pacientes con reseccion parcial o completa del tumor.