Erin M. Mannen

Mechanical analysis of the human cadaveric thoracic spine with intact rib cage

The goal of this study was to characterize the overall in-plane and basic coupled motion of a cadaveric human thoracic spine with intact true ribs. Researchers are becoming increasingly interested in the thoracic spine due to both the high prevalence of injury and pain in the region and also innovative surgical techniques that utilize the rib cage. Computational models can be useful tools to predict loading patterns and understand effects of surgical procedures or medical devices, but they are often limited by insufficient cadaveric input data. In this study, pure moments to ±5 Nm were applied in flexion-extension, lateral bending, and axial rotation to seven human cadaveric thoracic spine specimens (T1-T12) with intact true ribs to determine symmetry of in-plane motion, differences in neutral and elastic zone motion and stiffness, and significance of out-of-plane rotations and translations. Results showed that lateral bending and axial rotation exhibited symmetric motion, neutral and elastic zone motion and stiffness values were significantly different for all modes of bending (p<0.05), and out-of-plane rotations and translations were greater than zero for most rotations and translations. Overall in-plane rotations were 7.7±3.4° in flexion, 9.6±3.7° in extension, 23.3±8.4° in lateral bending, and 26.3±12.2° in axial rotation. Results of this study could provide inputs or validation comparisons for computational models. Future studies should characterize coupled motion patterns and local and regional level biomechanics of cadaveric human thoracic spines with intact true ribs.

Mechanical Contribution of the Rib Cage in the Human Cadaveric Thoracic Spine.

Study Design. An in vitro biomechanical human cadaveric study of T1–T12 thoracic specimens was performed with 4 conditions (with and without rib cage, instrumented and uninstrumented) in flexion-extension, lateral bending, and axial rotation. Objective. The objective was to understand the influence of the rib cage on motion and stiffness parameters of the human cadaveric thoracic spine. Hypotheses tested for overall motion in all modes of bending for both uninstrumented and instrumented specimens were (i) in-plane range of motion and neutral and elastic zones will be greater without the rib cage, (ii) neutral and elastic zone stiffness values will be different for specimens without the rib cage, and (iii) out-of-plane rotations will be different for specimens without the rib cage. Summary of Background Data. The rib cage is presumed to provide significant stability to the thoracic spine, but no studies have been conducted to determine the influence of the rib cage in both uninstrumented and instrumented conditions in the full thoracic human cadaveric specimens. Methods. Seven human cadaveric spine specimens (T1–T12) with 4 conditions (with and without rib cage, instrumented and uninstrumented) were subjected to 5 N·m pure moments in flexion-extension, lateral bending, and axial rotation. Range of motion, neutral and elastic zones, neutral and elastic zone stiffness values, and out-of-plane rotations were calculated for the overall specimen. Results. In-plane range of motion was significantly higher without a rib cage for most modes of bending. Out-of-plane motions were also influenced by the rib cage. Neutral zone stiffness was significantly higher with a rib cage present. Conclusion. Testing without a rib cage yields different motion and stiffness measures, directly impacting the translation of research results to clinical interpretation. Researchers should consider these differences when evaluating the mechanical impact of surgical procedures or instrumentation in cadaveric or computational models. Level of Evidence: 5

Effects of follower load and rib cage on intervertebral disc pressure and sagittal plane curvature in static tests of cadaveric thoracic spines

The clinical relevance of mechanical testing studies of cadaveric human thoracic spines could be enhanced by using follower preload techniques, by including the intact rib cage, and by measuring thoracic intervertebral disc pressures, but studies to date have not incorporated all of these components simultaneously. Thus, this study aimed to implement a follower preload in the thoracic spine with intact rib cage, and examine the effects of follower load, rib cage stiffening and rib cage removal on intervertebral disc pressures and sagittal plane curvatures in unconstrained static conditions. Intervertebral disc pressures increased linearly with follower load magnitude. The effect of the rib cage on disc pressures in static conditions remains unclear because testing order likely confounded the results. Disc pressures compared well with previous reports in vitro, and comparison with in vivo values suggests the use of a follower load of about 400N to approximate loading in upright standing. Follower load had no effect on sagittal plane spine curvature overall, suggesting successful application of the technique, although increased flexion in the upper spine and reduced flexion in the lower spine suggest that the follower load path was not optimized. Rib cage stiffening and removal both increased overall spine flexion slightly, although with differing effects at specific spinal locations. Overall, the approaches demonstrated here will support the use of follower preloads, intact rib cage, and disc pressure measurements to enhance the clinical relevance of future studies of the thoracic spine.

Effect of follower load on motion and stiffness of the human thoracic spine with intact rib cage

Researchers have reported on the importance of the rib cage in maintaining mechanical stability in the thoracic spine and on the validity of a compressive follower preload. However, dynamic mechanical testing using both the rib cage and follower load has never been studied. An in vitro biomechanical study of human cadaveric thoracic specimens with rib cage intact in lateral bending, flexion/extension, and axial rotation under varying compressive follower preloads was performed. The objective was to characterize the motion and stiffness of the thoracic spine with intact rib cage and follower preload. The hypotheses tested for all modes of bending were (i) range of motion, elastic zone, and neutral zone will be reduced with a follower load, and (ii) neutral and elastic zone stiffness will be increased with a follower load. Eight human cadaveric thoracic spine specimen (T1-T12) with intact rib cage were subjected to 5Nm pure moments in lateral bending, flexion/extension, and axial rotation under follower loads of 0-400N. Range of motion, elastic and neutral zones, and elastic and neutral zone stiffness values were calculated for functional spinal units and segments within the entire thoracic section. Combined segmental range of motion decreased by an average of 34% with follower load for every mode. Application of a follower load with intact rib cage impacts the motion and stiffness of the human cadaveric thoracic spine. Researchers should consider including both aspects to better represent the physiologic implications of human motion and improve clinically relevant biomechanical thoracic spine testing.

Validation of a Novel Spine Test Machine

A novel spine test machine was developed for physiological loading of spinal segments. It can be used in conjunction with external motion-capture systems (EMCS) to measure angular displacement, but can also measure in-plane rotations directly, though the inherent error is unknown. This study quantified error inherent in the displacement measurement of the machine. Synthetic specimens representative of cadaveric spinal specimens were tested. Machine displacement was compared to EMCS displacement. The maximum machine displacement error was <2 deg for lumbar and thoracic specimens. The authors suggest that researchers use EMCS in conjunction with the test machine when high accuracy measurements are required.

The rib cage reduces intervertebral disc pressures in cadaveric thoracic spines by sharing loading under applied dynamic moments

The effects of the rib cage on thoracic spine loading are not well studied, but the rib cage may provide stability or share loads with the spine. Intervertebral disc pressure provides insight into spinal loading, but such measurements are lacking in the thoracic spine. Thus, our objective was to examine thoracic intradiscal pressures under applied pure moments, and to determine the effect of the rib cage on these pressures. Human cadaveric thoracic spine specimens were positioned upright in a testing machine, and Dynamic pure moments (0 to ±5 N·m) with a compressive follower load of 400 N were applied in axial rotation, flexion - extension, and lateral bending. Disc pressures were measured at T4-T5 and T8-T9 using needle-mounted pressure transducers, first with the rib cage intact, and again after the rib cage was removed. Changes in pressure vs. moment slopes with rib cage removal were examined. Pressure generally increased with applied moments, and pressure-moment slope increased with rib cage removal at T4-T5 for axial rotation, extension, and lateral bending, and at T8-T9 for axial rotation. The results suggest the intact rib cage carried about 62% and 56% of axial rotation moments about T4-T5 and T8-T9, respectively, as well as 42% of extension moment and 36-43% of lateral bending moment about T4-T5 only. The rib cage likely plays a larger role in supporting moments than compressive loads, and may also play a larger role in the upper thorax than the lower thorax.

Influence of Sequential Ponte Osteotomies on the Human Thoracic Spine With a Rib Cage

STUDY DESIGN Biomechanical cadaveric study. OBJECTIVES The purpose of this study was to determine the change in range of motion (ROM) of the human thoracic spine and rib cage due to sequential Ponte osteotomies (POs). SUMMARY OF BACKGROUND DATA POs are often performed in deformity correction surgeries to provide flexibility in the sagittal plane at an estimated correction potential of 5° per PO, but no studies have evaluated the biomechanical impact of the procedure on a cadaveric model with an intact rib cage. METHODS Seven human thoracic cadavers with intact rib cages were loaded with pure moments in flexion, extension, axial rotation, and lateral bending for five conditions: intact, PO at T9-T10, PO at T8-T9, PO at T7-T8, and PO at T6-T7. Motion of T1, T6, and T10 were measured, and overall (T1-T12) and regional (T6-T10) ROMs were reported for each mode of bending at each condition. RESULTS POs increased ROM in flexion both overall (T1-T12) and regionally (T6-T10), although the magnitude of the increase was marginal (<1°/PO). No significant differences were found in axial rotation or lateral bending. CONCLUSIONS POs may increase sagittal correction potential before fusion in patients with hyperkyphosis, though more work should be done to determine the magnitude of the changes. LEVEL OF EVIDENCE Level V.STUDY DESIGN Biomechanical cadaveric study. OBJECTIVES The purpose of this study was to determine the change in range of motion (ROM) of the human thoracic spine and rib cage due to sequential Ponte osteotomies (POs). POs are often performed in deformity correction surgeries to provide flexibility in the sagittal plane at an estimated correction potential of 5° per PO, but no studies have evaluated the biomechanical impact of the procedure on a cadaveric model with an intact rib cage. METHODS Seven human thoracic cadavers with intact rib cages were loaded with pure moments in flexion, extension, axial rotation, and lateral bending for five conditions: intact, PO at T9-T10, PO at T8-T9, PO at T7-T8, and PO at T6-T7. Motion of T1, T6, and T10 were measured, and overall (T1-T12) and regional (T6-T10) ROMs were reported for each mode of bending at each condition. RESULTS POs increased ROM in flexion both overall (T1-T12) and regionally (T6-T10), although the magnitude of the increase was marginal (<1°/PO). No significant differences were found in axial rotation or lateral bending. CONCLUSIONS POs may increase sagittal correction potential before fusion in patients with hyperkyphosis, though more work should be done to determine the magnitude of the changes. LEVEL OF EVIDENCE Level V.

Biomechanical Evaluation of a Growth-Friendly Rod Construct

BACKGROUND Distraction-type rods mechanically stabilize the thorax and improve lung growth and function by applying distraction forces at the rib, spine, pelvis, or a combination of locations. However, the amount of stability the rods provide and the amount the thorax needs is unknown. METHODS Five freshly frozen and thawed cadaveric thoracic spine specimens were tested for lateral bending, flexion/extension, and axial rotation in displacement control (1°/sec) to a load limit of ±5 Nm for five cycles after which a growth-friendly unilateral rod was placed in a simulated rib-to-lumbar attachment along the right side. The specimens were tested again in the same modes of bending. From the seven Optotrak Orthopedic Research Pin markers (Northern Digital Inc., Waterloo, Ontario, Canada) inserted into the top potting to denote T1, and the right pedicles at T2, T4, T5, T8, T9, and T11 and the Standard Needle Tip Pressure Transducers (Gaeltech, Isle of Skye, Scotland) inserted into the T4/T5 and T8/T9 discs, motion, stiffness, and pressure data were calculated. Parameters from the third cycle of the intact case and the construct case were compared using two-tailed paired t tests with 0.05 as the level of significance. RESULTS With the construct attached, the T1-T4 segment showed a 30% increase in neutral zone stiffness during extension (p =.001); the T8-T12 segment experienced a 63% reduction in the in-plane range of motion during flexion (p =.04); and the T8/T9 spinal motion unit had a significant decrease of 24% in elastic zone stiffness during left axial rotation (p =.04). CONCLUSIONS It is clear the device as tested here does not produce large biomechanical changes, but the balance between providing desired changes while preventing complications remains difficult.BACKGROUND Distraction-type rods mechanically stabilize the thorax and improve lung growth and function by applying distraction forces at the rib, spine, pelvis, or a combination of locations. However, the amount of stability the rods provide and the amount the thorax needs is unknown. METHODS Five freshly frozen and thawed cadaveric thoracic spine specimens were tested for lateral bending, flexion/extension, and axial rotation in displacement control (1°/sec) to a load limit of ±5 Nm for five cycles after which a growth-friendly unilateral rod was placed in a simulated rib-to-lumbar attachment along the right side. The specimens were tested again in the same modes of bending. From the seven Optotrak Orthopedic Research Pin markers (Northern Digital Inc., Waterloo, Ontario, Canada) inserted into the top potting to denote T1, and the right pedicles at T2, T4, T5, T8, T9, and T11 and the Standard Needle Tip Pressure Transducers (Gaeltech, Isle of Skye, Scotland) inserted into the T4/T5 and T8/T9 discs, motion, stiffness, and pressure data were calculated. Parameters from the third cycle of the intact case and the construct case were compared using two-tailed paired t tests with 0.05 as the level of significance. RESULTS With the construct attached, the T1-T4 segment showed a 30% increase in neutral zone stiffness during extension (p = .001); the T8-T12 segment experienced a 63% reduction in the in-plane range of motion during flexion (p = .04); and the T8/T9 spinal motion unit had a significant decrease of 24% in elastic zone stiffness during left axial rotation (p = .04). CONCLUSIONS It is clear the device as tested here does not produce large biomechanical changes, but the balance between providing desired changes while preventing complications remains difficult.

The rib cage stiffens the thoracic spine in a cadaveric model with body weight load under dynamic moments

The thoracic spine presents a challenge for biomechanical testing. With more segments than the lumbar and cervical regions and the integration with the rib cage, experimental approaches to evaluate the mechanical behavior of cadaveric thoracic spines have varied widely. Some researchers are now including the rib cage intact during testing, and some are incorporating follower load techniques in the thoracic spine. Both of these approaches aim to more closely model physiological conditions. To date, no studies have examined the impact of the rib cage on thoracic spine motion and stiffness in conjunction with follower loads. The purpose of this research was to quantify the mechanical effect of the rib cage on cadaveric thoracic spine motion and stiffness with a follower load under dynamic moments. It was hypothesized that the rib cage would increase stiffness and decrease motion of the thoracic spine with a follower load. Eight fresh-frozen human cadaveric thoracic spines with rib cages (T1-T12) were loaded with a 400 N compressive follower load. Dynamic moments of ± 5 N m were applied in lateral bending, flexion/extension, and axial rotation, and the motion and stiffness of the specimens with the rib cage intact have been previously reported. This study evaluated the motion and stiffness of the specimens after rib cage removal, and compared the data to the rib cage intact condition. Range-of-motion and stiffness were calculated for the upper, middle, and lower segments of the thoracic spine. Range-of-motion significantly increased with the removal of the rib cage in lateral bending, flexion/extension, and axial rotation by 63.5%, 63.0%, and 58.8%, respectively (p < 0.05). Neutral and elastic zones increased in flexion/extension and axial rotation, and neutral zone stiffness decreased in axial rotation with rib cage removal. Overall, the removal of the rib cage increases the range-of-motion and decreases the stiffness of cadaveric thoracic spines under compressive follower loads in vitro. This study suggests that the rib cage should be included when testing a cadaveric thoracic spine with a follower load to optimize clinical relevance.

Position of the Hip in Yoga

BACKGROUND Yoga is growing in popularity as a form of exercise throughout the world. Orthopedic patients participate in yoga, yet little is known about the ranges-of-motion of the hip within various yoga poses. Orthopedic surgeons are unsure about what potential positions their patients are placing their hips during a yoga practice. The aim of this study is to quantify the degree of hip motion with common yoga poses. METHODS Twenty healthy, regular practitioners of yoga performed 11 different yoga poses in a standardized fashion. Motion analysis was used to capture range-of-motion of the hip during each pose. RESULTS Many yoga poses put the hip in extremes of motion. Poses such as downward dog, forward fold, seated twist, and pigeon stressed the hip in flexion. Warrior 1, warrior 2, crescent lunge, pigeon, and triangle stressed the hip in extension. Eagle and seated twist put the hip in higher adduction, while half moon, eagle, and triangle produced more hip internal rotation. CONCLUSION Many poses were found to reach extremes of hip motion. This study may help guide the orthopedic surgeon in counseling hip arthroplasty and hip impingement patients about yoga-related activity. By knowing which poses potentially stress the hip in particular planes of motion, surgeons may better inform their patients who are returning to yoga after injury or surgery.