Erol Selimoglu

Does Adenotonsillectomy Improve Growth in Children with Obstructive Adenotonsillar Hypertrophy

Faltering growth may be associated with adenotonsillar hypertrophy, but its pathophysiological mechanism is unclear. This study included 29 pre-pubertal children with obstructive adenotonsillar hypertrophy, and aimed to investigate the probable difference in energy intake and serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels before and 6 months after adenotonsillectomy. Weight and height standard deviation scores, energy intake per kilogram and serum IGF-1 levels were found to be significantly higher 6 months after adenotonsillectomy, indicating that adenotonsillar hypertrophy is associated with poor growth.

Primary nasopharyngeal tuberculosis in a patient with the complaint of snoring

Isolated nasopharyngeal tuberculosis is a rare condition, even in endemic tuberculosis areas. The most common presentation of nasopharyngeal tuberculosis is with a cervical lymphadenopathy followed by nasal discharge or obstruction. Here we present a 58-year-old patient with nasopharyngeal tuberculosis whose only complaint was snoring. Her oropharyngeal and anterior rhinoscopic examination was normal. On endoscopic examination, mucosal oedema and hyperaemia of the nasopharynx was observed. There was no cervical lymphadenopathy. The tuberculin skin test was positive and histopathological examination of the biopsy taken from posterior nasopharyngeal wall supported the diagnosis of tuberculosis. After anti-tuberculosis therapy, the snoring stopped and the nasopharyngeal examination was normal.

Effects of semirapid maxillary expansion on conductive hearing loss.

INTRODUCTION Conductive hearing loss is affected by physical changes imposed on the mechanical system of the outer or middle ear. Maxillary expansion can affect conductive hearing loss, and the changes have been investigated with pure-tone audiograms. Semirapid and slow methods of maxillary expansion have some advantages over rapid maxillary expansion, but the effects on conductive hearing loss have not been investigated. The purpose of this study was to investigate long-term effects of semirapid maxillary expansion (SRME) with an acrylic bonded appliance on conductive hearing loss by using audiometric and tympanometric records. METHODS The effects of SRME with a bonded appliance were studied in 19 growing subjects who had narrow maxillary arches and conductive hearing loss. Hearing levels were determined with pure-tone audiometric and tympanometric records. Four records were taken from each subject. The first records were taken before SRME, the second after maxillary expansion (mean, 3.4 months later), the third after retention (mean, 6 months later), and the fourth after fixed-appliance treatment (approximately 2 years later). The data were analyzed with ANOVA. The least-significant difference test was also used to determine when the changes in the measurements were significant. RESULTS Hearing improved and air-bone gaps decreased at a statistically significant level after active expansion, and these changes remained relatively stable during the last 2 periods. Middle-ear volume increased at a statistically significant level after maxillary expansion and continued to increase until the end of treatment. No significant change was observed in the static compliance value. CONCLUSIONS SRME treatment has a positive and statistically significant effect on both hearing and normal functioning of the eustachian tubes in patients with transverse maxillary deficiency and conductive hearing loss.

Primary tonsillar tuberculosis: a case report

A 67-year-old man with an enlarged left tonsil underwent a tonsillectomy for the suspicion of malignancy. He had had a dental extraction six months earlier. Clinical and histopathological investigations established the diagnosis of primary tonsillar tuberculosis.

A giant teratoma of the tongue.

Teratoma of the tongue is an extremely rare tumour of the oral cavity, which is composed of ectoderm, mesoderm and endoderm with differentiation to identifiable tissues and organs. We described a female neonate with a giant teratoma of the tongue and an incomplete cleft palate. The tumour was attached to 1/3 right anterior of her tongue and its largest diameter was 13 cm. Histopathologically, it consisted of stratified squamous epithelium on the surface, and ciliated prismatic epithelium, cartilage and neuroglial tissue. Two years after excision there was no sign of recurrence.

Comparative Cochlear Toxicities of Streptomycin, Gentamicin, Amikacin and Netilmicin in Guinea-Pigs

All the aminoglycoside antibiotics now in clinical use are ototoxic. This study was designed to compare the toxic effects of four aminoglycoside antibiotics, streptomycin, gentamicin, amikacin and netilmicin, administered to guinea-pigs systemically (at respective doses of 125 mg/kg, 50 mg/kg, 150 mg/kg or 37.5 mg/kg, twice daily for 1 week) or topically via the transtympanic route (0.25 ml/kg in 4% saline, twice daily for 1 week). Chosen doses were 10–20 times higher than the recommended human dosage. Cochlear damage was observed in all animals that were given systemic and local aminoglycosides. The severity of the cochlear damage was in the order gentamicin, amikacin, streptomycin, netilmicin, with gentamicin being the most toxic. No statistically significant difference between the severity of cochlear damage resulting from the systemic and topical applications was detected.

Haemangiopericytoma of the middle ear : case report and literature review

Haemangiopericytoma is an uncommon vascular tumour that rarely appears in the head and neck region. Such a tumour arising from the middle ear has not been reported since it was first described in 1942 by Stout and Murray. The present case therefore illustrates the first example of a primary middle ear haemangiopericytoma.

Trichorhinophalangeal syndrome type III in Turkish siblings

[1] Crolla JA, Howard P, Mitchell C, Long FL, Dennis NR. A molecular and FISH approach to determining karyotype and phenotype correlations in six patients with supernumerary marker (22) chromosomes. Am J Med Genet 1997;/72:/440 7. [2] Ing PS, Lubinsky MS, Smith SD, Golden E, Sanger WG, Duncan AMV. Cat-eye syndrome with different marker chromosomes in a mother and daughter. Am J Med Genet 1987;/26:/ 621 8. [3] Liehr T, Pfeiffer RA, Trautmann U. Typical partial cat-eye syndrome: identification of the marker chromosome by FISH. Clin Genet 1992;/42:/91 6. [4] Berends MJW, tan-Sindhunata G, Leegte B, Van Essen AJ. Phenotypic variability of cat-eye syndrome. Genet Couns 2001;/ 12:/23 34.

The effect of piracetam in preventing combined cisplatin and gentamicin-induced ototoxicity in a guinea pig model

Abstract Aim. To investigate the protective effect of piracetam in preventing combined cisplatin and gentamicin-induced ototoxicity in a guinea pig model. Methods. Thirty-two male albino adult guinea pigs were used in this study. The animals were separated into three groups: Group I (control group; n = 10) received saline, Group II (CG group; n = 12) received combined cisplatin (3.5 mg/kg = 3.5 ml/kg) and gentamicin (100 mg/kg = 2.5 ml/kg), and Group III (PCG group; n = 10) received piracetam (350 mg/kg = 1.75 ml/kg) plus the combined cisplatin (3.5 mg/kg = 3.5 ml/kg) and gentamicin (100 mg/kg = 2.5 ml/kg) as a single dose/day for 5 consecutive days, intraperitoneally. Auditory brainstem response (ABR), wave absolute latencies (ALs) and interpeak latencies (IPLs) for each ear (n = 64) of all animals (n = 32) were monitored. Results. Significant differences were found between CG and PCG groups in terms of ABR wave II AL (p < 0.01), III AL (p < 0.001), IV AL (p < 0.001), I-III IPL (p < 0.001), III-IV IPL (p...