Ersoy Acer

Acute generalized exanthematous pustulosis associated with terbinafine: a case report

Abstract A 27-year-old male patient who has used oral terbinafine for two weeks was admitted to our outpatient clinic for non-follicular millimetric pustules on erythematous and edematous different-sized plaques on his trunk and flexural areas. He was diagnosed with acute generalized exanthematous pustulosis (AGEP) because of terbinafine use in the light of history, clinical and histopathological findings. An AGEP is a rare and severe pustular reaction usually triggered by systemic drug intake. Approximately, 2.3% of the patients having oral terbinafine have been reported to develop cutaneous adverse effects. Although terbinafine is a commonly used medicine, it must be considered that it may cause severe adverse reactions.

Psoriazisli Hastalarda Serum Asimetrik Dimetilarjinin (ADMA) ve Yüksek Sensitif C-Reaktif Protein (hsCRP) Seviyeleri

Aim: Asymmetric dimethylarginine (ADMA) is a major inhibitor of nitric oxide synthesis inhumans. Recent reports have demonstrated that elevated high sensitive C-reactive protein(hsCRP), an inflammatory marker, and plasma ADMA levels are associated with endothelialdysfunction and increased atherogenesis. We aimed to determine the presence of endothelialdysfunction in psoriatic patients and if psoriazis is an independent risk factor for cardiovasculardiseases by measuring the serum levels of ADMA and hsCRP in patients with psoriazis.Material and Methods: Thirty five psoriatic patients not having traditional cardiovascular riskfactors and 26 healthy controls were included into the study. Serum levels of ADMA, hsCRP,HDL, LDL, triglyceride, and total cholesterol, and BMI analyses were assessed and comparedbetween patient and control subjects. The association of psoriazis area and severity index (PASI)scores with ADMA and hsCRP levels were evaluated. Results: There was no statistically significant difference for the demographic characteristics,and all laboratory parameters levels between psoriazis and control groups. ADMA values were0.63±0.30 μmol/L (mean±sd) and 0.68±0.45 μmol/L (mean±sd) in patients and control group,respectively. hsCRP levels were 1.40±1.51 mg/L (mean±sd) in control group, while 1.91±2.13mg/L (mean±sd) in patients group. There was no statistically significant difference betweenpatients and control groups, in terms of ADMA and hsCRP values (p>0.05). Statisticallysignificance and moderate correlation was found between PASI scores and serum hsCRP levels(r=0,73; p<0,01).Conclusion: This study concludes that there isn’t an increasedvascular endothelial dysfunction which could be shown by ADMAand hsCRP biochemical markers in mild and moderate psoriazis.Also, it suggests that mild and moderate psoriazis is not anindependent risk factor for cardiovascular diseases. However, itis concluded that the levels of hsCRP could be used as an objectivemarker alternative to PASI to determine the response to thetreatment and the severity of the disease

Familial lichen planus: case report -

Lichen planus is an idiopathic and inflammatory dermatosis affecting skin, mucosa, and nails. The exact etiopathogenesis is unknown, but autoimmunity, viruses, vaccinations, contact allergens, drugs, stress and genetic predisposition may have roles. Familial lichen planus has been rarely reported. However, the increase in familial cases day by day, strengthens the place of genetic predisposition in pathogenesis. Herein, we report a familial case of lichen planus in a mother and daughter

Hereditary angioedema on the occasion of a pediatric case

Hereditary angioedema is a rare and life threatening autosomal-dominant disorder which results from the congenital deficiency of C1- esterase inhibitor. It is responsible for approximately 2% of all angioedema cases. Recurring angioedema attacks that involve subcutaneous and submucosal areas are the hallmarks of hereditary angioedema. Here, we review the clinical findings and therapeutic approaches of the disease by presenting a 5-years old female patient with severe extremity edema who was diagnosed as hereditary angioedema and treated with fresh frozen plasma.