Erwan Arzel
AstraZeneca
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Publication
Featured researches published by Erwan Arzel.
Bioorganic & Medicinal Chemistry Letters | 2010
Britt-Marie Swahn; David Wensbo; Johan Sandell; Daniel Sohn; Can Slivo; David Pyring; Jonas Malmström; Erwan Arzel; Michaela Vallin; Margareta Bergh; Fredrik Jeppsson; Allan E. Johnson; Anders Juréus; Jan Neelissen; Samuel P.S. Svensson
The syntheses and SAR of new series of beta-amyloid binding agents are reported. The effort to optimize signal-to-background ratios for these ligands are described. Compounds 8, 21 and 30 displayed desirable lipophilicity and pharmacokinetic properties. Compounds 8 and 21 were evaluated with in vitro autoradiographic studies and in vivo in APP/PS1 transgenic mice. It is shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds 8 and 21.
Bioorganic & Medicinal Chemistry Letters | 2006
Britt-Marie Swahn; Yafeng Xue; Erwan Arzel; Elisabet Kallin; Angelika Magnus; Niklas Plobeck; Jenny Viklund
Archive | 2006
Per I. Arvidsson; Erwan Arzel; Jeremy N. Burrows; Helena Gyback; Tobias Rein; Didier Rotticci; Peter Söderman
Archive | 2006
Per I. Arvidsson; Erwan Arzel; Jeremy N. Burrows; Martina Claesson; Colin Ray; Tobias Rein; Didier Rotticci; Peter Söderman
Archive | 2006
Lars I. Andersson; Erwan Arzel; Stefan Berg; Jeremy N. Burrows; Sven Hellberg; Fernando Huerta; Torben Pedersen; Tobias Rein; Didier Rotticci; Karin Staaf
Archive | 2004
Niklas Plobeck; Britt-Marie Swahn; Erwan Arzel
Archive | 2008
Erwan Arzel; Louise Edwards; Methvin Isaac; Donald Mcleod; Abdelmalik Slassi; Tao Xin
Archive | 2008
Erwan Arzel; Britt-Marie Swahn; David Wensbo
Archive | 2006
Louise Edwards; Methvin Isaac; Abdelmalik Slassi; Guang-Ri Sun; Peter Dove; Erwan Arzel
Archive | 2009
Erwan Arzel; Louise Edwards; Methvin Isaac; Donald A. Mcleod; Abdelmalik Slassi; Tao Xin
