Erwan Sugiatno

Hybrid micro/nanostructural surface offering improved stress distribution and enhanced osseointegration properties of the biomedical titanium implant

OBJECTIVES The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. MATERIALS AND METHODS The surface characteristic, biomechanical behavior and hemocompatibility of the MST-Ti dental implant were performed using scanning electron microscope, finite element method, blood dripping and immersion tests. The mini-pig model was utilized to evaluate the bone tissue response and osseointegration of the MST-Ti dental implant in vivo. Data were analyzed by analysis of variance using the Students t-test (P ≤ 0.05). RESULTS The hybrid volcano-like micro/nanoporous structure was formed on the surface of the MST-Ti dental implant. The hybrid volcano-like micro/nanoporous surface played an important role to improve the stress transfer between fixture, cortical bone and cancellous bone for the MST-Ti dental implant. Moreover, the MST-Ti implant was considered to have the outstanding hemocompatibility. In vivo testing results showed that the bone-to-implant contact (BIC) ratio significantly altered as the implant with micro/nanoporous surface. After 12 weeks of implantation, the MST-Ti dental implant group exhibited significantly higher BIC ratio than the untreated dental implant group. In addition, the MST-Ti dental implant group also presented an enhancing osseointegration, particularly in the early stages of bone healing. CONCLUSION It can be concluded that the micro-arc oxidation approach induced the formation of micro/nanoporous surface is a promising and reliable alternative surface modification for Ti dental implant applications.

Early bone response to machined, sandblasting acid etching (SLA) and novel surface‐functionalization (SLAffinity) titanium implants: characterization, biomechanical analysis and histological evaluation in pigs

The purpose of the present study was to examine early tissue response and osseointegration in the animal model. The surface morphologies of SLAffinity were characterized using scanning electron microscopy and atomic force microscopy. The microstructures were examined by X-ray diffraction, and hardness was measured by nanoindentation. Moreover, the safety and toxicity properties were evaluated using computer-aided programs and cell cytotoxicity assays. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received three implants: machine, sandblasted, large grit, acid-etched, and SLAffinity-treated implants. The results showed that surface treatment did affect bone-to-implant contact (BIC) significantly. At 3 weeks, the SLAffinity-treated implants were found to present significantly higher BIC values than the untreated implants. The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing. As described above, the results of the present study demonstrate that the SLAffinity treatment is a reliable surface modification method.

The influence of chicken scratch collagen with local hydroxyapatite as bone substitute material toward the bone remodelling of Rattus Sprague Dawley

Alveolar bone resorption has affected thousands of patients after tooth extraction and disturbing the retention and stabilization of denture. Hydroxyapatite has been used as bone substitute material, but it has several weaknesses. The purpose of this study was to observe the influence of chicken scratch collagen with local hydroxyapatite as bone substitute material toward the bone remodelling of Rattus Sprague Dawley. The subject of the remodelling test was 75 male of Rattus Sprague Dawley; each was 3 months old. All of the subjects was divided into 3 groups. The group I was local hydroxyapatite chicken scratch collagen, the group II was chicken scratch collagen, and the group III was local hydroxyapatite-collagen. Each of subject was decapitated after 3, 7, 10, 14, 28 days after treatment. The defect was made in the femur condyle of Rattus Sprague Dawley with the size of 3×3×2 mm3. The defect area was taken and made histological slides. The number of osteoblast and osteoclast were measured with a trinocu...