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Dive into the research topics where Essam M. Hussein is active.

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Featured researches published by Essam M. Hussein.


Russian Journal of Bioorganic Chemistry | 2014

A green synthetic approach to the synthesis of Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile as potential anti-inflammatory agents.

Sh. A. Abdel-Mohsen; Essam M. Hussein

A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their anti-inflammatory activity “at a dose of 10 mg/kg body weight,” which revealed promising activities relative to indomethacin used as a reference standard in this study.


Phosphorus Sulfur and Silicon and The Related Elements | 2008

Synthesis and Reactions of Some New Spiropyranthiazoline Derivatives

Maher F. El-Zohry; Yasser A. Elossaily; Thanaa A. Mohamed; Essam M. Hussein

Pyrano[2,3-d]thiazoline-7-spiro-3′-(1′-substitutedindoline-2′-ones) 5a,b has been synthesized and reacted with some nucleophile reagents to afford new spirothiazolino[4,5:2′,3′]pyrano[6′,5′-d]pyrimidine derivatives 6a,b–13a,b, which are analogues of some reported biologically active spiroheterocyclic compounds.


Zeitschrift für Naturforschung B | 2012

Enviro-economic, Ultrasound-assisted One-pot, Three-component Synthesis of Pyrido(2,3-d)pyrimidines in Aqueous Medium

Essam M. Hussein

Tetra-n-butyl ammonium bromide (TBAB) was found to be an efficient phase-transfer catalyst for the synthesis of pyrido[2,3-d]pyrimidines by one-pot reaction of 6-aminouracils, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in water under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, short reaction time, easy work-up, improved yields, and the use of water as a solvent that is environmentally benign. Graphical Abstract Enviro-economic, Ultrasound-assisted One-pot, Three-component Synthesis of Pyrido[2,3-d]pyrimidines in Aqueous Medium


Heterocyclic Communications | 2017

A convenient regioselective synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety through a [3 + 2]-cycloaddition reaction

Essam M. Hussein; Saleh A. Ahmed; Ismail I. Althagafi

Abstract A facile one-pot synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety was accomplished in good yields through a 1,3-dipolar cycloaddition reaction of 3-aryl-1-(pyren-1-yl)prop-2-en-1-one derivatives with in situ-generated azomethine ylides.


Zeitschrift für Naturforschung B | 2015

Synthesis of some novel 6′-(4-chlorophenyl)-3,4′-bipyridine-3′-carbonitriles: assessment of their antimicrobial and cytotoxic activity

Essam M. Hussein; Hossa F. Al-Shareef; Amany H. Aboellil; Heba A. Elhady

Abstract A series of novel substituted 6′-(4-chlorophenyl)-3,4′-bipyridine-3′-carbonitriles with incorporated pyrazole and/or triazole moieties have been synthesized using 2-(6′-(4-chlorophenyl)-3′-cyano-3,4′-bipyridin-2′-yloxy)acetohydrazide (3) as starting material. Also, the key intermediate 3 reacted with aromatic aldehydes and tosyl chloride to give the corresponding Schiff bases and tosyl hydrazide derivatives, respectively. The antimicrobial of these newly synthesized compounds was evaluated against Bacillus subtilis as Gram-positive bacteria and Trichoderma viride as a fungus; some of these compounds such as 5, 6, 7, 8, 10, 12, and 14 showed excellent activities as antimicrobial agents. Moreover, the cytotoxic activity of the most active compounds was assessed in vitro against human tumor liver cancer cell line (HEPG2); compounds 8, 10, 13a, and 14 showed potent activities relative to Doxorubicin which was used as a reference standard drug in this study.


Monatshefte Fur Chemie | 2013

Ultrasound-promoted efficient domino reaction for the one-pot synthesis of spiro-5-cyanopyrimidines: a rapid procedure

Essam M. Hussein


Journal of Heterocyclic Chemistry | 2012

Simple and Clean Procedure for Three-Component Syntheses of Spiro{pyrido[2,1-b]benzothiazole-3,3′-indolines} and Spiro{thiazolo[3,2-a]pyridine-7,3′-indolines} in Aqueous Medium

Essam M. Hussein; Ahmed M. El-Khawaga


Arkivoc | 2011

Regioselective synthesis and anti-inflammatory activity of novel dispiro[pyrazolidine-4,3'-pyrrolidine-2',3'-indoline]-2',3,5-triones

Essam M. Hussein; Maisa I. Abdel-Monem


Heterocycles | 2008

Synthesis and reactions of some new spiro{indeno〔1,2-b〕pyran-4,3'-indolines}

Maher F. El-Zohry; Yasser A. Elossaily; Thanaa A. Mohamed; Essam M. Hussein


Monatshefte Fur Chemie | 2009

Novel syntheses of some new 3,4-dihydrospiro{benzimidazo[1,2-a]pyridine-3,3′-indolin}-2′-one derivatives

Maher F. El-Zohry; Thanaa A. Mohamed; Essam M. Hussein

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