Essam M. Hussein
Assiut University
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Publication
Featured researches published by Essam M. Hussein.
Russian Journal of Bioorganic Chemistry | 2014
Sh. A. Abdel-Mohsen; Essam M. Hussein
A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their anti-inflammatory activity “at a dose of 10 mg/kg body weight,” which revealed promising activities relative to indomethacin used as a reference standard in this study.
Phosphorus Sulfur and Silicon and The Related Elements | 2008
Maher F. El-Zohry; Yasser A. Elossaily; Thanaa A. Mohamed; Essam M. Hussein
Pyrano[2,3-d]thiazoline-7-spiro-3′-(1′-substitutedindoline-2′-ones) 5a,b has been synthesized and reacted with some nucleophile reagents to afford new spirothiazolino[4,5:2′,3′]pyrano[6′,5′-d]pyrimidine derivatives 6a,b–13a,b, which are analogues of some reported biologically active spiroheterocyclic compounds.
Zeitschrift für Naturforschung B | 2012
Essam M. Hussein
Tetra-n-butyl ammonium bromide (TBAB) was found to be an efficient phase-transfer catalyst for the synthesis of pyrido[2,3-d]pyrimidines by one-pot reaction of 6-aminouracils, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in water under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, short reaction time, easy work-up, improved yields, and the use of water as a solvent that is environmentally benign. Graphical Abstract Enviro-economic, Ultrasound-assisted One-pot, Three-component Synthesis of Pyrido[2,3-d]pyrimidines in Aqueous Medium
Heterocyclic Communications | 2017
Essam M. Hussein; Saleh A. Ahmed; Ismail I. Althagafi
Abstract A facile one-pot synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety was accomplished in good yields through a 1,3-dipolar cycloaddition reaction of 3-aryl-1-(pyren-1-yl)prop-2-en-1-one derivatives with in situ-generated azomethine ylides.
Zeitschrift für Naturforschung B | 2015
Essam M. Hussein; Hossa F. Al-Shareef; Amany H. Aboellil; Heba A. Elhady
Abstract A series of novel substituted 6′-(4-chlorophenyl)-3,4′-bipyridine-3′-carbonitriles with incorporated pyrazole and/or triazole moieties have been synthesized using 2-(6′-(4-chlorophenyl)-3′-cyano-3,4′-bipyridin-2′-yloxy)acetohydrazide (3) as starting material. Also, the key intermediate 3 reacted with aromatic aldehydes and tosyl chloride to give the corresponding Schiff bases and tosyl hydrazide derivatives, respectively. The antimicrobial of these newly synthesized compounds was evaluated against Bacillus subtilis as Gram-positive bacteria and Trichoderma viride as a fungus; some of these compounds such as 5, 6, 7, 8, 10, 12, and 14 showed excellent activities as antimicrobial agents. Moreover, the cytotoxic activity of the most active compounds was assessed in vitro against human tumor liver cancer cell line (HEPG2); compounds 8, 10, 13a, and 14 showed potent activities relative to Doxorubicin which was used as a reference standard drug in this study.
Monatshefte Fur Chemie | 2013
Essam M. Hussein
Journal of Heterocyclic Chemistry | 2012
Essam M. Hussein; Ahmed M. El-Khawaga
Arkivoc | 2011
Essam M. Hussein; Maisa I. Abdel-Monem
Heterocycles | 2008
Maher F. El-Zohry; Yasser A. Elossaily; Thanaa A. Mohamed; Essam M. Hussein
Monatshefte Fur Chemie | 2009
Maher F. El-Zohry; Thanaa A. Mohamed; Essam M. Hussein