Eugene Eisenberg

Childhood hypophosphatasia and the premature loss of teeth: A clinical and laboratory study of seven cases

Abstract Hypophosphatasia, an inheritable metabolic disease, causes a premature loss of deciduous teeth. Because of the early dental exfoliation, the dentist is often consulted first. The diagnosis can be established by certain clinical features, x-ray findings, and chemical abnormalities. The childhood form of the disease is self-limiting and does not require treatment.

Inhibition of Aerobic Respiration of Rat Brain by Desoxycorticosterone in vitro.

Summary (1) The concentration-action relationships of DC and DCG upon aerobic respiration of rat brain cell suspensions indicate: (a) Increasing amounts of DC and DCG produce increasing amounts of inhibition This relationship is reasonably linear plotting the logarithm of the amount of DC against per cent of inhibition produced. (b) With increasing amounts of DC a longer period of time is required to attain maximal inhibition while a comparable effect is more rapidly attained with equimolar amounts of the water-soluble conjugate, DCG. The effect, once attained, remains constant without further increase or release of the inhibition. (c) By this bio-assay the water-solubility of DC at 37.2°C is approximately 3.6×10-3 Molar. (2) These data suggest that, under the conditions used, the relatively large amounts of steroid necessary to produce inhibition of aerobic respiration in vitro entirely penetrate or are adsorbed by the affected system. These amounts exceed the concentrations of steroid which will affect other systems in vitro or that occur in living organisms. This does not necessarily exclude the possibility that steroidal inhibition of aerobic respiration may be of significance in the intact organism.

The Singularly Brief Anabolic Activity of Testololactone, A Compound Lacking Androgenicity

Summary Testololactone has been demonstrated to have protein-anabolic activity, having passed both the levator ani screening test and a confirmatory nitrogen balance study. This compound showed a rapid effect, remarkably evanescent, which after quickly wearing off was followed by the rebound of nitrogen excretion in the urine to the basal level when testololactone treatment was continued. Testololactone is completely non-androgenic at the very high dose of 10 mg per day.

Prolongation and Potentiation of Anabolic and Androgenic Effects of Steroids Testosterone and Methylandrostenediol.

Summary 1. Testosterone cyclopentylpropionate shows the greatest anabolic and androgenic efficacy of the agents studied. Its increased efficacy cannot be explained on the basis of delayed absorption, suggesting a delayed inactivation of this ester. 2. Aluminum phosphate delays the onset and decline of the anabolic and androgenic actions of testosterone in aqueous suspensions, but produces no such effect upon the actions of methylandrostenediol.

Antitumor efficacy of 7α, 17α‐dimethyltestosterone in disseminated breast cancer

In a study of the antitumor efficacy of androgen derivatives in the treatment of advanced carcinoma of the female breast, a highly potent anabolic and androgenic steroid, 7α, 17α‐dimethyltestosterone, was compared by the double‐blind technique with 2α‐methyldihydrotestosterone. The latter is a weak androgen with antitumor efficacy similar to that of testosterone propionate. Both were administered orally, the dimethyllated steroid in a dose of 10 mg daily, the 2α‐methyldihydrotestosterone in a dose of 150 mg daily. Five of 25 women treated with 7α, 17α‐dimethyltestosterone (20%) had objective regressions compared with 2 of 25 women receiving 2α‐methyldihydrotestosterone (8%). There was a higher incidence of virilization and BSP retention with 7α, 17α‐dimethyltestosterone but no jaundice or other evidence of hepatocellular damage.