Eun-Hye Jo
Seoul National University
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Publication
Featured researches published by Eun-Hye Jo.
European Journal of Cancer Prevention | 2007
Eun-Hye Jo; Soo-Jin Lee; Nam-Shik Ahn; Joon-Suk Park; Jae-Woong Hwang; Sung-Hoon Kim; Okezie I. Aruoma; Yong-Soon Lee; Kyung-Sun Kang
Oligonol is a novel catechin-rich biotechnology product. The role of oligonol in modulating intracellular signaling mechanisms was investigated with the view of demonstrating its potential chemopreventive effect and the ability to inhibit cell proliferation using the estrogen-responsive MCF-7 and the estrogen-unresponsive MDA-MB-231 human breast cancer cell lines. Cell survival assay indicated that Oligonol was cytotoxic to both cells. Oligonol triggered apoptosis as revealed by the morphological features typical of nucleus staining and the accumulation of sub-G1 peak. Treatment with 25 μg/ml Oligonol resulted in an activation of caspase-7 and up-regulation of Bad on MCF-7 cells, while the Oligonol (20 μg/ml) induced up-regulation of Bcl-2 protein in a time–response manner on MDA-MB-231 cells. ERK1/2 in both cells were inactivated after Oligonol treatment in a time-dependent manner, and also inactivated upstream MEK1/2. Oligonol triggers apoptosis in MCF-7 and MDA-MB-231 cells through the modulation of pro-apoptotic Bcl-2 family proteins and MEK/ERK signaling pathway.
European Journal of Cancer Prevention | 2007
Eun-Hye Jo; Sung-Hoon Kim; Nam-Shik Ahn; Joon-Suk Park; Jae-Woong Hwang; Yong Soon Lee; Kyung-Sun Kang
Sulforaphane is an antioxidant and a potent stimulator of natural detoxifying enzyme and associated with lowered risk of cancer that is associated with the consumption of cruciferous vegetables. The chemopreventive effects of SFN was investigated using the MCF-7 human breast cancer cells and the M13SV1-immortalized human breast luminal epithelial cells. Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2. Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells. These results suggest that sulforaphane may be an alternative candidate for targeted prevention of ER-positive and cyclooxygenase-2-induced phenotypes and breast cancer.
Cancer Letters | 2005
Eun-Hye Jo; Sung-Hoon Kim; Jeong-Chan Ra; Sung-Ran Kim; Sung-Dae Cho; Ji-Won Jung; Se-Ran Yang; Joon-Suk Park; Jae-Woong Hwang; Okezie I. Aruoma; Tae-Yung Kim; Yong-Soon Lee; Kyung-Sun Kang
Journal of Agricultural and Food Chemistry | 2004
Eun-Hye Jo; ‡ Hee-Do Hong; † Nam-Chik Ahn; Ji-Won Jung; Se-Ran Yang; Joon-Suk Park; Sung-Hoon Kim; † and Yong-Soon Lee; Kyung-Sun Kang
Cancer Letters | 2005
Ji-Won Jung; Sung-Dae Cho; Nam-Shik Ahn; Se-Ran Yang; Joon-Suk Park; Eun-Hye Jo; Jae-Woong Hwang; J.-W. Jung; Sung-Hoon Kim; Kyung-Sun Kang; Yong-Soon Lee
Mutation Research | 2005
Se-Ran Yang; Sung-Dae Cho; Nam-Shik Ahn; Ji-Won Jung; Joon-Suk Park; Eun-Hye Jo; Jae-Woong Hwang; Sung-Hoon Kim; Bonghee Lee; Kyung-Sun Kang; Yong-Soon Lee
Journal of Agricultural and Food Chemistry | 2005
Jae-Woong Hwang; Joon-Suk Park; Eun-Hye Jo; Sun-Jung Kim; Byoung-Su Yoon; Sung-Hoon Kim; Yong-Soon Lee; Kyung-Sun Kang
European Journal of Cancer Prevention | 2006
Cho Sd; Nam-Shik Ahn; Ji-Youn Jung; Yang; Park Js; Yong-Soon Lee; Eun-Hye Jo; Jae-Woong Hwang; Lii J; Kang Ks
Biofactors | 2006
Jung-Ran Park; Joon-Suk Park; Eun-Hye Jo; Jae-Woong Hwang; Sun-Jung Kim; Jeong-Chan Ra; Okezie I. Aruoma; Yong Soon Lee; Kyung-Sun Kang
Cancer Letters | 2006
Ji-Won Jung; Sung-Dae Cho; Nam-Shik Ahn; Se-Ran Yang; Joon-Suk Park; Eun-Hye Jo; Jae-Woong Hwang; Okezie I. Aruoma; Yong Soon Lee; Kyung-Sun Kang