Eun-Jin Lee

Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer

This study was conducted to identify genetic factors predisposing to TP53 mutations in patients with non-small cell lung cancer (NSCLC). A comprehensive panel of potentially functional single nucleotide polymorphisms (SNPs) in DNA repair genes was evaluated in relation to TP53 mutations. Thirty-seven SNPs in 28 DNA repair genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. Four SNPs (XPA rs1800975, OGG1 rs1052133, ADPRT rs1136410, and NBS1 rs1805794) were significantly associated with the prevalence of TP53 mutations in multivariate analysis for each SNP. When the 4 SNPs were combined, the prevalence of TP53 mutations was increased as the number of bad genotypes increased (P(trend)=0.001). Patients with 3 and 4 bad genotypes had a significantly higher frequency of TP53 mutations than those with 0-1 bad genotypes (adjusted odds ratio=5.18, 95% confidence interval=1.51-17.81, P=0.01 and adjusted odds ratio=18.26, 95% confidence interval=2.87-116.09, P=0.002, respectively). These findings suggest that the 4 SNPs may modulate the occurrence of TP53 mutations and contribute to lung carcinogenesis. However, larger studies are required to confirm our findings in other ethnic populations.

The influence of TP53 mutations on the prognosis of patients with early stage non-small cell lung cancer may depend on the intratumor heterogeneity of the mutations.

A large number of studies have evaluated the impact of TP53 mutations on the prognosis of patients with non‐small cell lung cancer (NSCLC); however, the results of these studies are still controversial. Recently, considerable intratumor heterogeneity for genetic alterations has been demonstrated in various human cancers, including lung cancer. In the present study, we evaluated TP53 mutations in NSCLCs by direct sequencing and observed remarkable variation in the values of relative intensity (RI, the height of the peak of mutated allele/the height of the peak of non‐mutated allele) of the mutations. We also examined whether the RI values were associated with intratumor heterogeneity of TP53 mutations. In addition, we evaluated the relationship between TP53 mutations and survival outcome. The patients with a TP53 mutation did not have significantly worse survival compared to those without the mutation. However, when tumors with a TP53 mutation were categorized into two groups, those with a low and those with a high RI, the latter group had significantly worse survival compared to those with wild‐type TP53 (adjusted hazard ratiou2009=u20092.58, 95% confidence intervalu2009=u20091.21–5.48, Pu2009=u20090.01), whereas the former group did not. These results suggest that intratumor genetic heterogeneity may be an important factor in determining the role of TP53 mutations on the prognosis of NSCLC patients.

A Qualitative Study on Design Copying of Fashion Industry

Abstract : Copying of designs has been condoned in the fashion industry. However, the industry argues that whetherfashion design should be protected by law and what constitute design copying in fashion. This study has been performedby in-dept interviews with employees in the fashion industry. The study finds that respondents perceived copying ofdesign to be some extent beneficial to the industry. While, they also observed that it has a negative effect on the industrydue to indiscriminate copying. In regards to standard of drawing the line between copying and inspiration or modification,designers have subjective and discrepant standards. Fashion industry itself, consumers biased preference, inefficient edu-cation and lack of legislation are significantly engaged in design copying. Key words:design copying, intellectual property, fashion industry 1. 서론 지식기반경제와 함께 지식재산이 중요한 가치로 부각되면서모든 산업에 걸쳐 지식재산권에 대한 관심이 증가하고 그 중요성이 강조되고 있다. 패션산업에서도 상표 및 디자인 도용, 위조 상품의 제조와 판매, 불법 유통 등 지식재산권과 관련한 다양한 문제가 발생하고 있다(홍병숙, 석효정, 2009). 이 중 상표권과 직접 관련된 브랜드의 위조 상품이나 소비자에게 혼란을야기하는 유사상표 문제는 상표권 침해에 해당하며 불법행위라는 인식이 널리 퍼져있고 정부나 국제기구, 패션기업 자체 내에서 문제 해결을 위한 관련법안 실행, 자체 감시기구 설립, 소비자 계몽 등 강력한 대응책을 내놓고 있다. 하지만, 의류나 액세서리 디자인의 모방 문제에 있어서는 패션업계의 오랜 관행으로 치부하여 문제해결과 방지에 소극적인 태도를 보이고 있다(김혜영, 김민호, 1999; Hemphill & Suk, 2009; Hilton etal., 2004). 특히 유행이라는 배경 속에서 디자인 모방을 당연시하는 풍토가 만연해 있고(최현정, 2004), 창작(creativity)과 디자인 영감(design inspiration), 응용과 모방간의 경계의 모호함,모방에 대한 객관적 판단 기준의 부재, 그리고 디자인 모방으로 인한 물질적 피해와 브랜드 가치 손상으로 인한 무형의 손실을 법정에서 증명하기가 쉽지 않다는 어려움이 있다(홍병숙,석효정, 2009). 그러나 전 세계적으로 지식재산권이 강화되면서국내외 패션산업에서 지식재산권과 관련된 소송이 증가하고 있으며, 국내 패션업계에서도 상표 도용 및 디자인 모방 등으로인한 기업들 간의 법정소송, 구두경고, 내용증명 발송 등의 분쟁사례가 빈번이 일어나고 있다(“패션의류 상표권”, 2006; “패션업체 디자인”, 2008).미국 법학계와 패션업계에서는 미국패션디자이너협회(Councilof Fashion Designers of America)의 주도하에 추진되고 있는디자인 도용 방지법안(Innovative Design Protection andPiracy Prevention Act, Senate Bill 3728)을 두고 패션디자인모방을 법적으로 제재하는 것이 과연 패션산업의 발전에 도움이 되는가의 문제와 과거 DPPA(Design Piracy ProtectionAct)법안에 명시되었던 ‘상당히 유사함(close and substantiallysimilar)’이라는 위반기준을 ‘보호된 디자인의 요소(elements)와전체적인 외관(visual appearance)이 상당히 똑같음(substantiallyidentical)’으로 변경한 후에도 여전히 남아있는 모호한 판단기준에 대한 논의가 활발히 진행되고 있다(“Design Piracy”,2010).국내에서는 패션디자인이 디자인보호법, 저작권법 및 부정경쟁방지법 등에 의해 법적인 보호를 받을 수 있지만, 디자인보호법은 디자인의 등록요건과 등록까지의 기간, 등록절차, 비용부담 문제 등으로 인해 매 시즌 다량의 새로운 디자인이 출시

The Effect of Person-Environment Fit on Organization Attractiveness, Commitment, and Job Satisfaction in TV Home Shopping Companies

This study analyzes how the person-environment fit on organization attractiveness, commitment, and job sat- isfaction in TV home shopping companies. The survey was conducted from May 3 to 31 in 2010, and 350 responses were used in the data analysis. The statistical analysis methods were frequency analysis, factor analysis, reliability analysis, and multiple regression analysis. The results show that person-environment fit of TV home shopping companies is composed of person-job fit, person-supervisor fit, and person- organization fit. The person-job fit, person-supervisor fit, and person- organization fit of TV home shopping companies influence the organization attractiveness and commitment. The orga- nization attractiveness and commitment affect the job satisfaction in TV home shopping companies.

패션 소비자의 환경의식, 처분 추구가치, 지속가능한 패션소비태도와 패션처분행동에 관한 연구

This study identified fashion consumers disposal behavior and analyzed the effects of consumers pursuing values in disposal, environmental awareness, and sustainable fashion consumption attitudes in regards to fashion disposal behavior. A survey questionnaire was developed and data were obtained from 460 consumers in their 20`s to 50`s in Korea who had experienced fashion disposal behaviors during last 12 months. As a result, there were four different fashion disposal behaviors such as economical, practical, and social disposal as well as hoarding behaviors. Consumers pursuing values in disposal affected fashion disposal behavior. Practical and economical values had positively impacted economical disposal and hoarding behaviors. While hedonic value had a negative impact on economical disposal behavior, it had a positive impact on social disposal behavior. Also, environmental-social values had positively impacted practical and social disposal behaviors. Fashion-related environmental knowledge had positively impacted economical and practical disposal behaviors and PCE affected social disposal behavior, while environmental concerns had a negative impact on economical disposal behavior. Consumers attitude toward usedfashion items, fashion recycling, and fashion innovativeness affected all of fashion disposal behaviors. Although hoarding behavior has been an under researched area, the finding implied that hoarding behavior was affected by consumer`s pursuing value in disposal and sustainable consumption attitude. Also, environmental-social values and attitudes toward used-fashion items would induce practical disposal behavior such as reuse by alteration or reform. Consumers economical and hedonic values can promote donations or exchange/resale of unwanted fashion items, which can lead to sustainable consumption.

The Materials and Shapes of the Western Style Shoes in Korea in the 1920s to 1930s

This study considered the change process for Western style shoes in Korea during the time of modernization in the 1920s to 1930s. Western style shoes were one of the items imported by foreigners since the Joseon Dynasty and had a significant impact on Korean dress code. It influence started to sprea...

The Effects of Individualism-Collectivism Propensity, Social Capital, Participation Activity of Social Network Service Users on Fashion Brands Relationship Orientation

This study analyzed the effect of individualism-collectivism propensity and social capital on participation activity as well as the effect of participation activity on fashion brands relationship orientation of social network service users. Also, this study investigated the difference in participation activity and fashion brands relationship orientation by participation level of social network service. A survey was conducted from October 1 to November 31, 2015, and 476 responses were used in the analysis. As results, the individualism-collectivism propensity was composed of vertical-horizontal individualism and vertical-horizontal collectivism. The social capital was composed of trust, norm, and network. Also, the participation activity was composed of personal interaction, consumer rights, information pursuit, interest pursuit, and economic pursuit. Vertical individualism positively affected information pursuit and economic pursuit, and horizontal individualism positively affected personal interaction, consumer rights, and information pursuit; in addition, vertical collectivism positively affected personal interaction, consumer rights, and interest pursuit. Horizontal collectivism positively affected information pursuit, but it negatively affected consumer rights. Consumer rights, information pursuit, interest pursuit, and economic pursuit of participation activity positively affected fashion brands relationship orientation. Also, there were significant differences in the participation activity and fashion brands relationship orientation by participation level. The study results provide useful information to the marketing strategies using social network service of fashion brands.

Abstract 1488: Association between microrna binding site polymorphism and susceptibility to colorectal cancer in Korean population

Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAnnBackground : MicroRNAs (miRNAs) play an important role in the colorectal cancer tumorigenesis by regulation of gene expression through binding to 3′ untranslational region (UTR) of target gene. Single nucleotide polymorphism (SNP) within 3′UTR of gene could be affected by miRNA binding. Docking protein 3 (DOK3) is adapter protein that acts as tumor suppressor through modulating tyrosine kinase signaling.nnMethods : One hundred thirty five SNPs were selected in Silico analysis for the current study from 3′UTR SNPs of SNP database, which was based on several miRNA database, calculating miRNA bind efficiency on polymorphism, and HapMap database. Here independent two set of study was designed, 380 healthy controls and 371 colorectal adenocarcinoma patients were enrolled in discovery set, and 524 healthy controls and 521 colorectal adenocarcinoma patients were enrolled in replication set. The SNP genotyping was performed using the Sequenom MassARRAYnnResult: In discovery set, 16 SNPs were significantly associated with colorectal cancer in any genetic model from 135 SNP genotyping. Among 16 SNPs, DOK3 rs2279398G>A was significantly associated in replication set recessive model (adjusted odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.44-0.97, P = 0.03). In combined analysis, DOK3 rs2279398G>A was associated with significantly decreased risk of colorectal cancer in codominant and recessive model (adjusted OR = 0.84, 95% CI = 0.73-0.96, P = 0.012, adjusted OR = 0.65, CI = 0.49-0.88, P = 0.004, respectively).nnConclusion : DOK3 rs2279398G>A may affect the expression of DOK3 by altering miRNA binding efficiency on miRNA-binding sites of the 3′-UTR of DOK3 and impact on colorectal cancer tumorigenesis. This finding suggests that DOK3 rs2279398G>A may be a useful biomarker for determining the susceptibility to colorectal cancer.nnCitation Format: Byung Woog Kang, Hyosung Jeon, Yee Soo Chae, Soo Jung Lee, Jong Gwang Kim, Hyunchul Lee, Eun-Jin Lee, Myung Hoon Lee, Jae Yong Park, Gyu Seog Choi, Jun Seok Park. Association between microrna binding site polymorphism and susceptibility to colorectal cancer in Korean population. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1488. doi:10.1158/1538-7445.AM2014-1488