Ewa Rej
University of Sydney
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Publication
Featured researches published by Ewa Rej.
Nature Communications | 2015
Ewa Rej; Torsten Gaebel; Thomas Boele; David E. J. Waddington; D. J. Reilly
The use of hyperpolarized agents in magnetic resonance, such as 13C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 s for 13C liquid-state compounds, which limit the time that the signal remains boosted. Here we demonstrate that 1.1% natural abundance 13C spins in synthetic nanodiamond can be hyperpolarized at cryogenic and room temperature without the use of free radicals, and, owing to their solid-state environment, exhibit relaxation times exceeding 1 h. Combined with the already established applications of nanodiamonds in the life sciences as inexpensive fluorescent markers and non-cytotoxic substrates for gene and drug delivery, these results extend the theranostic capabilities of nanoscale diamonds into the domain of hyperpolarized magnetic resonance.
Nature Communications | 2017
David E. J. Waddington; Mathieu Sarracanie; Huiliang Zhang; Najat Salameh; David R. Glenn; Ewa Rej; Torsten Gaebel; Thomas Boele; Ronald L. Walsworth; D. J. Reilly; Matthew S. Rosen
Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton–electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.
Journal of the American Chemical Society | 2017
Ewa Rej; Torsten Gaebel; David E. J. Waddington; D. J. Reilly
The widespread use of nanodiamond as a biomedical platform for drug-delivery, imaging, and subcellular tracking applications stems from its nontoxicity and unique quantum mechanical properties. Here, we extend this functionality to the domain of magnetic resonance, by demonstrating that the intrinsic electron spins on the nanodiamond surface can be used to hyperpolarize adsorbed liquid compounds at low fields and room temperature. By combining relaxation measurements with hyperpolarization, spins on the surface of the nanodiamond can be distinguished from those in the bulk liquid. These results are likely of use in signaling the controlled release of pharmaceutical payloads.
arXiv: Mesoscale and Nanoscale Physics | 2016
David E. J. Waddington; Mathieu Sarracanie; Huiliang Zhang; Najat Salameh; David R. Glenn; Ewa Rej; Torsten Gaebel; Thomas Boele; Ronald L. Walsworth; D. J. Reilly; Matthew S. Rosen
arXiv: Mesoscale and Nanoscale Physics | 2018
Girish Sharma; Torsten Gaebel; Ewa Rej; D. J. Reilly; Sophia E. Economou; Edwin Barnes
Advances in Photonics of Quantum Computing, Memory, and Communication XI | 2018
David E. J. Waddington; Mathieu Sarracanie; Huiliang Zhang; Najat Salameh; David Glenn; Ewa Rej; Torsten Gaebel; Thomas Boele; Ronald L. Walsworth; D. J. Reilly; M. S. Rosen
Archive | 2017
David E. J. Waddington; Thomas Boele; Ewa Rej; Dane R. McCamey; Nicholas J. C. King; Torsten Gaebel; D. J. Reilly
Bulletin of the American Physical Society | 2017
Ewa Rej; Torsten Gaebel; Thomas Boele; David E. J. Waddington; D. J. Reilly
Bulletin of the American Physical Society | 2017
Torsten Gaebel; Ewa Rej; Thomas Boele; David E. J. Waddington; D. J. Reilly
Bulletin of the American Physical Society | 2013
Ewa Rej; David E. J. Waddington; Torsten Gaebel; D. J. Reilly