Ezgi Ünlü

Congenital pilar leiomyoma.

Piloleiomyomas are benign smooth muscle tumors arising from the arrectores pilorum muscles in the skin. They usually occur as multiple firm dermal nodules located on the extremities and trunk. Solitary lesions are rare. Leiomyomas usually develop during adolescence or early adult life. Congenital pilar leiomiyoma is an extremely rare entity. We present a case of congenital solitary pilar leiomyoma located on the face.

Photosensitive Rash in Association with Porphyrin Biosynthesis Possibly Induced by Docetaxel and Trastuzumab Therapy in a Patient with Metastatic Breast Carcinoma

Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including hypersensitivity, oedema, skin toxicity with erythrodysesthesia syndrome, infusion site reactions, alopecia, nail onycholysis, nail pigmentation, photosensitivity, scleroderma and stomatitis. However, of all the reported effects, photosensitivity has only rarely been described in the literature. We experienced a case of cutaneous photosensitivity with aberrations in porphyrin biosynthesis that developed 1 month after the patient received combination chemotherapy consisting of docetaxel and trastuzumab. The eruption resolved with sun avoidance and discontinuation of docetaxel therapy. To our knowledge, this is the first case of a photosensitive reaction with enhanced levels of porphyrins during docetaxel therapy.

Comparison of dermatoscopic diagnostic algorithms based on calculation: The ABCD rule of dermatoscopy, the seven-point checklist, the three-point checklist and the CASH algorithm in dermatoscopic evaluation of melanocytic lesions.

Dermatoscopic analysis of melanocytic lesions using the CASH algorithm has rarely been described in the literature. The purpose of this study was to compare the sensitivity, specificity, and diagnostic accuracy rates of the ABCD rule of dermatoscopy, the seven‐point checklist, the three‐point checklist, and the CASH algorithm in the diagnosis and dermatoscopic evaluation of melanocytic lesions on the hairy skin. One hundred and fifteen melanocytic lesions of 115 patients were examined retrospectively using dermatoscopic images and compared with the histopathologic diagnosis. Four dermatoscopic algorithms were carried out for all lesions. The ABCD rule of dermatoscopy showed sensitivity of 91.6%, specificity of 60.4%, and diagnostic accuracy of 66.9%. The seven‐point checklist showed sensitivity, specificity, and diagnostic accuracy of 87.5, 65.9, and 70.4%, respectively; the three‐point checklist 79.1, 62.6, 66%; and the CASH algorithm 91.6, 64.8, and 70.4%, respectively. To our knowledge, this is the first study that compares the sensitivity, specificity and diagnostic accuracy of the ABCD rule of dermatoscopy, the three‐point checklist, the seven‐point checklist, and the CASH algorithm for the diagnosis of melanocytic lesions on the hairy skin. In our study, the ABCD rule of dermatoscopy and the CASH algorithm showed the highest sensitivity for the diagnosis of melanoma.

Dermatoscopic findings of atrophic dermatofibrosarcoma protuberans

Dermatofibrosarcoma protuberans (DFSP) is an uncommon locally aggressive mesenchymal tumor with a high local recurrence rate. Atrophic DFSP is a rare variant of DFSP characterized by a non-protuberant lesion. We report on a 23-year-old female, who presented with an atrophic, asymptomatic macule on the right side of her back 2 cm in diameter. Dermatoscopic examination revealed homogenous pigment network on a purplish erythematous background. The histopathological finding of the incisional biopsy material was consistent with DFSP. To our knowledge, this is the second case of atrophic DFSP discussing the dermatoscopic features of this relatively rare condition.

A giant mass on the scalp: an unusual presentation of lupus vulgaris

Lupus vulgaris (LV) is a paucibacillary form of cutaneous tuberculosis (TB) that may arise in case of slight immunosuppression which results in moderate to high immunity against the pathogen. Predilection sites are buttocks and trunk. TB reemerges to be a serious medical problem due to HIV infection, organ transplants, and thus increase in the number of immunocompromised patients. Cutaneous TB comprises only less than 1–2% of the cases. Mycobacterium TB and unusually Mycobacterium bovis cause cutaneous TB. LV is the most common form of cutaneous TB which may lead to disfigurement if not diagnosed and treated properly. LV arises in patients with slight immunosuppression and the bacilli count in the lesions is low because of the immune response. Here, we describe a neglected atypical case of LV with complete clinical and histopathological response to antituberculous treatment (ATT) in an immunocompetent woman.

A Case of Adult Onset Classical Type of Nevus Lipomatosus Cutaneous Superficialis

Nevus lipomatosus cutaneous superficialis is a rare malformation characterized by the presence of ectopic adipocytes in the dermis. Two types of it have been described. The classical type, firstly reported by Hoffman and Zurhelle, is presented with multiple, unilateral, soft, nontender, pedinculated, skin colored or yellowish papules, plaques and nodules with smooth or cerebriform surface. The lesions are usually congenital or appear in the first two decades of life. The main location of the classical type is pelvic girdle. Solitary type of nevus lipomatosus cutaneous superficialis usually occurs as a single nodular lesion after the age of 20 and typical localization has not been described. We report the case of a 46-year-old female with classical type of nevus lipomatosus cutaneous superficialis on the right lumbar region that developed five years ago.

Mikozis Fungoides İle İlişkili Pitriazis Rotunda = Pityriasis Rotunda Associated With Mycosis Fungoides

Pitriazis rotunda govde ve ekstremitelerde yerlesen, keskin sinirli, yuvarlak veya oval sekilli, uzeri skuamli asemptomatik makullerle karakterize nadir gorulen bir deri hastaligidir. Etyolojisi henuz bilinmemektedir. Bazi otorler kazanilmis ya da konjenital iktiyozisin bir formu ya da tuberkuloz, malnutrisyon, hepatoselluler kanser, lenfoma, losemi, multipl myelom, mide kanseri, kardiak ve pulmoner hastaliklar gibi sistemik hastaliklarin deri belirtisi olabilecegine inanmaktadirlar. Mikozis fungoides tedavisi esnasinda ortaya cikan pitriazis rotunda daha once bildirilmemistir.