Seçil Saral

Basosquamous carcinoma: Dermoscopic clues to diagnosis.

Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the published work, except one study. The aim of the present study was to better identify and clarify the dermoscopic findings of BSC in the largest group of patients in the published work and to describe its dermoscopic features according to histopathologically BCC‐dominant, SCC‐dominant and intermediate categories. Dermoscopic features of 36 histopathologically proven BSC and their dermatopathological correlates were retrospectively analyzed. Dermoscopic features were evaluated by pattern analysis. Keratin mass (91.7%) was the most common dermoscopic feature. Surface scaling (77.8%), ulceration (69.4%), white structureless areas (69.4%), white clods (66.7%) and blood spots on keratin mass (66.7%) were the other frequent findings. Polymorphous vascular pattern consisting of various combinations of branched, serpentine, straight, coiled or looped vessels were detected in 61% of the lesions. BSC has BCC‐dominant vascular features together with otherwise SCC‐dominant morphology, the common pattern seen in BSC lesions being BCC‐dominant polymorphous or monomorphous vasculature, together with dermoscopic findings of keratinization. White circles, known to be a valuable clue to SCC and keratoacanthoma, were present at the same magnitude in BSC in our study. The observed histological correlation of eosinophilic keratin overlying the epithelium which lined follicular infundibulae in these tumors, provides a plausible new perspective on dermoscopic white circles.

Unique Presentation of Leukemic Cutaneous CD3/TCR- Phenotype T-Cell Lymphoma with Complete Remission after Allogeneic Stem Cell Transplantation

Histopathological examination of the ichthyotic skin showed perivascular dermal lymphoid cell infiltration in the superficial dermis and nodular and dense lymphoid cellular infiltration in the deep dermis. Lymphoid cells were CD3+ and CD20with a loss of CD7 expression. There were numerous (>25%) large, anaplastic cells with CD30 positivity among the lymphoid infiltrate. Clonal expansion of T cells in the lesional skin was demonstrated.

Retina dekolmanının eşlik ettiği iktiyozis folikülaris, alopesi ve fotofobi sendromlu bir olgu

Türkderm-Deri Hastalıkları ve Frengi Arşivi Dergisi, Galenos Yayınevi tarafından basılmıştır. Turkderm-Archives of the Turkish Dermatology and Venerology, published by Galenos Publishing. Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is a rare congenital ectodermal syndrome with X-linked inheritance. It occurs as a result of missense mutation in the chromosome Xp22.11-Xp22.13 locus of the MBTPS2 gene. It usually affects men and family history is negative. Ichthyosis follicularis and alopecia starts with birth. Photophobia and eye symptoms begin in early infancy or childhood. Other manifestations of the syndrome include short stature, mental retardation and seizures. There are no specific histopathological finding. A 29-year-old male patient was admitted to our outpatient clinic. Dermatological examination revealed keratosis pilaris localized to the scalp, lower and upper extremities, thighs, face and the trunk. The patient had xerosis, diffuse alopecia and prominent hair follicles. Eye examination revealed cataract and vision loss in the right eye. These findings led us to the diagnosis of IFAP syndrome. The patient is presented for the rarity of the syndrome in the literature. (Turkderm 2014; 48: 108-10)