F. A. Akbutina

Approaches to Epothilone Carboanalogs Starting from Δ3-Carene

Starting from (+)-Δ3-carene, synthetic equivalents of the C10-C16 fragment of epothilone carbo- analogs were obtained.

New chlorinated cyclopentenones prepared from hexachlorocyclopentadiene: synthesis, chemical properties, and application in the synthesis

The review surveys chemical conversions of 5-substituted 2,3,5-trichloro-4,4-dimethoxycyclopent-2-en-1-ones and related compounds and the possibilities of their use in the synthesis.

Prostanoids: LXXXII. Synthesis of Key Precursors of 9-LO Thromboxans

Starting from levoglucosan, methyl 2,4-dideoxy-3-O-mesyl-4-C-[(2Z)-octenyl]-α-D-arabino-hexopyranoside and (+)-2α-methoxy-6β-[6-methoxycarbonyl-3-oxo-(1E)-hexenyl]-5α-[(2Z)-octenyl]pyran-3-one were synthesized as potential building blocks for preparation of 9-LO thromboxanes.

Prostanoids: LXXXI. Synthesis of (±)-2-Decarboxy-2-ethyl-19,20-dinor-18-carboxyprostaglandin E1

Abstract2-Decarboxy-2-ethyl-19,20-dinor-18-carboxyprostaglandin E1 was synthesized starting from (±)-7α-hydroxy-6β-hydroxymethyl-2-oxa-cis-bicyclo[3.3.0]octan-3-one.

Prostanoids: LXXXV. Synthesis 9-Oxo Derivatives of 9-LO Thromboxans

Starting from levoglucosan, 1,6-anhydro-2,4-dideoxy-4-C-(2Z-octenyl)-β-D-arabino-hexopyranose was synthesized and converted into 9-oxo-9-LO thromboxan δ-lactone.

Reactions of secondary amines with derivatives of 5-(2-methyl-3-furyl)cyclopent-2-en-1-one

The reactions of 2,3,5-trichloro- and 2,5-dichloro-3-furfuryloxy-5-(2-methyl-3-furyl)-4,4-dimethoxycyclopent-2-en-1-ones with diethylamine or morpholine result in the decyclization of the 2-methylfuran substituent, giving the corresponding products in good yields.

Geminal Dimethyl-Substituted Functionalized C4-Synthons from Pantolactone

Some geminal dimethyl-substituted functionalized C4-synthons were prepared on the basis of (±)-pantolactone.

Some features of RuCl3-catalyzed periodate oxidation of 3-N-substituted 5-allenyl-2,5-dichloro-4,4-dimethoxycyclopent-2-en-1-ones

Abstract3-N-Substituted 5-(1Z-carboxymethylene)-2-chloro-4,4-dimethoxycyclopent-2-en-1-ones have been prepared from the corresponding 3-N-substituted 5-allenyl-2,5-dichloro-4,4-dimethoxycyclopent-2-en-1-ones using selective oxidative cleavage of their allene bond by the RuCl3−NaIO4 system.

Formation of isomeric iodohydrins from terminal alkenes upon oxidation by a RuCl3-NaIO4 system

RuCl3-catalyzed periodate oxidation of alkenes affords isomeric iodohydrins.

Prostanoids: LXXXVIII. Chlorocyclopentenone Building Blocks in the Synthesis of Marine Prostanoids

Starting from 2,3-dichloro-4,4-ethylenedioxy-2-cyclopentenone, a practical procedure has been developed for the synthesis of a series of 4-substituted 2-chloro-4-hydroxycyclopentenones.