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Publication
Featured researches published by F. Arena.
European Journal of Medicinal Chemistry | 1999
Antonia Sacchi; Sonia Laneri; F. Arena; Enrico Abignente; Marina Gallitelli; Michele D'Amico; Walter Filippelli; Francesco Rossi
Abstract The synthesis of a group of 2-phenylimidazo[1,2-b]pyridazine-3-acetic esters and acids is described. The structures of the new compounds are supported by 1 H-NMR spectra. These compounds were tested in vivo for their anti-inflammatory, analgesic and ulcerogenic activity. All new compounds showed remarkable anti-inflammatory action in the carrageenan rat paw oedema (one third of that for indomethacin) but no significant analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action, and were also found to be lacking inhibitory activity on cyclooxygenase in vitro.
European Journal of Medicinal Chemistry | 1998
Sonia Laneri; Antonia Sacchia; Marina Gallitelli; F. Arena; Elena Luraschi; Enrico Abignente; Walter Filippelli; Francesco Rossi
Abstract The synthesis of a group of 2-methylimidazo[1,2- a ]pyrimidine-3-carboxylic esters, acids and amides is described. The structures of new compounds are supported by 1 H and 13 C NMR spectra. These compounds were tested in vivo for their antiinflammatory, analgesic and ulcerogenic activity. Eight new compounds out of fifteenshowed remarkable dose-dependent antiinflammatory action in the carrageenan rat paw edema (1/2–1/3 × indomethacin) but weak analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action. The new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro.
Archiv Der Pharmazie | 1998
Anna Di Chiacchio; Maria Grazia Rimoli; Lucia Avallone; F. Arena; Enrico Abignente; Walter Filippelli; Amelia Filippelli; Guiseppe Falcone
A series of 2‐phenylimidazo[1,2‐a]pyridine‐3‐carboxylic esters, acids, and amides were synthesized and pharmacologically tested in order to evaluate their antiinflammatory and analgesic activity and their ulcerogenic action on the gastro‐intestinal tract. The most active member of this series of compounds was found to be 6‐methyl‐2‐phenylimidazo[1,2‐a]pyridine‐3‐carboxylic acid (5c).
European Journal of Medicinal Chemistry | 1997
Antonia Sacchi; Sonia Laneri; F. Arena; Elena Luraschi; E Attignente; M.D. Amico; L Berrino; Francesco Rossi
European Journal of Medicinal Chemistry | 1985
Enrico Abignente; F. Arena; P. De Caprariis; Rosaria Patscot; E. Marmo; E. Lampa; F. Rossi
ChemInform | 1985
Enrico Abignente; F. Arena; P. De Caprariis; Rosaria Patscot; E. Marmo; E. Lampa; F. Rossi
ChemInform | 2010
E. Luraschi; F. Arena; A. Sacchi; S. Laneri; Enrico Abignente
ChemInform | 2010
Enrico Abignente; F. Arena; P. De Caprariis; E. Luraschi; A. Sacchi; Carmela Saturnino
Pharmacological Research | 1992
Enrico Abignente; F. Arena; P. De Caprariis; E. Luraschi; A. Sacchi; Carmela Saturnino; M.G. Ri moli; F. Rossi; E. Lampa; L Berrino
ChemInform | 1982
Enrico Abignente; F. Arena; P. Decaprariis; E. Luraschi; E. Marmo; E. Lampa; G. Vairo; A. Somma