F. Colombo

Peyronie’s Disease: Prevalence and Association with Cigarette Smoking

Objectives: We present a multicenter, population–based epidemiological survey aimed at assessing the prevalence of Peyronie’s disease (PD) and its potential risk factors in the general population. Methods: In each of the ten centers throughout Italy, a uroandrologist contacted all the men in the age range 50–69 years registered with a general practitioner (GP). The subjects recruited were evaluated on the basis of their medical history, including alcohol consumption and cigarette smoking. The following questionnaires were administered: IIEF, IIPSS symptom score, premature ejaculation and PD. Results: All the subjects registered with a GP were invited to participate in the study. Of the 1,180 subjects, 647 (53%) entered over survey. In this population, 46 cases of PD were identified, accounting for a prevalence of 7.1%. The prevalence rate increased with age even if the trend is not statistically significant. The multivariate analysis showed a significant correlation between cigarette smoking and PD, with an odds ratio (OR) of 4.6 (CL 95%) confidence limit 1.506– 14.287). Smoking as single variable had an OR of 7.2 (95% CL 2.34–24.93). No significant association was observed between PD and the other variables such as cardiovascular diseases, diabetes, hypertension and alcohol consumption. Conclusions: PD is a much more frequent condition in the general population than previously reported. According to our results, cigarette smoking may be considered a risk factor for developing PD. If further and more targeted studies confirm that giving up smoking may reduce the risk of developing PD, then there will be new prospects for primary and secondary prevention and for curbing the progression of the disease.

PPTLBA-01 QUALITY OF LIFE AFTER PENILE PROSTHESIS IMPLANTATION – 1 YEAR FOLLOW-UP DATA OF THE ITALIAN PROSPECTIVE REGISTRY INSIST-ED

Paolo Capogrosso*, Giovanni Alei, Gabriele Antonini, Antonio Avolio, Antonio Barbieri, Carlo Bettocchi, Marco Bitelli, Francesco Boezio, Masssomo Capone, Enrico Caraceni, Maurizio Carrino, Carlo Ceruti, Sandro Ciampalini, Fulvio Colombo, Enrico Conti, Antonio Corvasce, Giuseppe Dachille, Diego Pozza, Stefano Fiordelise, Alessandro Franceschelli, Giulio Garaffa, Nicola Ghidini, FrancoGiorgio, Emilio Italiano, Giuseppe La Pera, Antonino Lagan a, Giovanni Liguori, Lilia Utizi, Matteo Matera, Nicola Mondaini, Alessandro Natali, Carlo Negro, Fabrizio Palumbo, Matteo Paradiso, Edoardo Pescatori, MassimoPolito,GaiaPolloni, AndreaSalonia,MauroSilvani, AldoTamai, Massimiliano Timpano, Francesco Varvello, Patrizio Vicini, Antonio Vitarelli, Antonio Palmieri, Federico Deh o, Milan, Italy

Technical Suggestions for Better and Lasting Functional and Aesthetic Outcomes in Creating the Neoclitoris

Urethral and clitoral reconstruction remains one of the most challenging fields in male-to-female sex reassignment surgery (SRS). It is a very difficult and demanding step of the intervention because the functionality and aesthetics are essential for a good outcome. Generally expectations of male-to-female transsexuals are very high, especially as regards cosmetics and functionality. To reach these expectations and to make the patient satisfied, a great knowledge of reconstructive surgery techniques and aesthetic refinements is required. In this chapter, we minutely describe the technique that permit to construct a functional and aesthetically pleasing neoclitoral complex emphasising the most important and critical steps of the intervention.

ATP Depletion: A Possible Role in the Pathogenesis of Uric Acid Nephrolithiasis in the Elderly

Undue acidity of the urine attributed to a deficiency in renal ammoniogenesis has been claimed to be prevalent in certain groups of patients who may form uric acid stones even in the absence of hyperuricosuria1.

Venous Surgery in Erectile Dysfunction: Therapeutic Strategy and Results

The therapeutic rationale of venous surgery is to create an effective obstacle to the pathologically increased venous outflow, determined by an intrinsic pathology of the cavernous bodies. In the last 15 years, many techniques have been proposed, and our therapeutic approach has evolved with our knowledge of penile haemodynamics. Up to October 1990, we performed 316 operations for the relief of impotence. In a 2-year follow-up our recurrence rates were as follows: DDV plus corporpexy (n = 50): 26% (n = 13); DDV plus crura plication (n = 34): 47% (n = 16); DDV plus collateral vein ligation (n = 48): 62.5% (n = 30).