F. Kradolfer

Eine neue gegen Bilharziose und Amoebiase wirksame Verbindung

5-[nitro-thiazolyl-(2)]-2-oxo-tetrahydroimidazole was found to possess schistosomicidal and amoebicidal properties. In mice this substance exhibited a curative effect in experimental infections withS. mansoni andS. japonicum. Preliminary clinical trials indicated that the compound is effective and well tolerated in the treatment of vesical bilharziasis.

Schutzwirkung von polysaccharidartigen Fraktionen bakterieller Herkunft bei einer experimentellen Virusinfektion

A polysaccharide like substance derived from cultivated bacteria is shown to exert a protective effect in mice infected with SK.-Col. Encephalomyelitis. The effect is optimally produced when the substance is applied previous to the infection. Certain changes in sera treated with the substance are observed involving normal virucidal factors of the sera.

Antagonistische Wirkung von Mucoprotein Gottschalk gegenüber Shearschem Polysaccharid an isolierten Zellen

Shears Polysaccharide and Gottschalks Virusreceptor-Mucoprotein are biological antagonists. The latter inhibits the stimulation of leucocytic migration produced by the former. Inhibition of virushaemagglutination by Gottschalks Mucoprotein is reversed by Shears Polysaccharide.

Zur Frage der Begleitstoffe in gonadotropen Hormonpräparaten

Substances obtained from urinary extracts were investigated for their inhibitory effect on virus hemagglutination (Hirst), and a comparison was made with the gonadotropic hormone activity of these substances. No clear-cut parallelity between these characteristics was demonstrable. An urinary extract substance was further tested both prior to and subsequent to contact with the virus receptor destroying enzyme (R.D.E.), for the three established properties, hormonal activity, leucocytotactic effect and influenza-virus-receptor characteristics. R.D.E. did not affect these three properties to the same degree. These results support the assumption that urinary extracts represent a mixture of chemically closely related substances.

Abhängigkeit der Antiviruswirkung bakterieller Polysaccharide von Behandlungstermin, Behandlungsdosis und Infektionsstärke

The paper analyses the protective or aggravating effect of a purified bacterial polysaccharide in Col.-SK.-Encephalomyelitis and infectious ectromelia in mice, as a function of the method of treatment. Both infections are influenced in a largely similar manner with a typical pattern of variation in the host resistance optimal effects depending on characteristic dose/time relations.

Cholesterin und Fettsäuren als Ersatz von Serum in der Kultur vonTrichomonas foetus

In the presence of a minimal amount of a water-soluble growth factor from bovine serum, cholesterol together with an unsaturated fatty acid may replace the ethersoluble lipoid fraction of the same serum. The concentration of cholesterol and fatty acid, as well as the chemical structure of the latter, are relevant.

Einfluss von Antikoagulantien auf Zellkernproteine

During osmotic hemolysis in the presence of heparin there is a marked increase in the viscosity of the cell suspension, which reaches its maximum only at a certain, fixed ratio of cell quantity to heparin. The increase in viscosity is accompanied by modifications of the structure of the cell nuclei. This process appears to affect the anticoagulant activity of heparin in a certain manner.