B. Schär

Weitere Untersuchungen über Bakterienchemotaxine

The majority of the bacteria investigated, in the living state exhibited leukotaxisin vitro; it is, however, mainly the gramnegative organisms and their culturefiltrates which contain active substances, probably of a polysaccharide-like nature, in readily demonstrable quantities.

[A chemically and pharmacologically novel antagonist of physiopathologically important amines, kinins and kinin-forming factors].

CIBA 21 401-Ba, a glucofuranoside derivative (ethyl-3,5,6-O-benzyl-d-glucofuranoside), antagonizes in vitro the smooth-muscle action of a large number of biogenic amines and polypeptides, the accelerated migration of leucocytes induced by endotoxin, and the Schultz-Dale phenomenon. In vivo, the compound shows anti-inflammatory and anti-allergic effects and improves the survival rate of infected mice treated with suboptimal doses of a sulphonamide.CIBA 21 401-Ba, a glucofuranoside derivative (ethyl-3,5,6-O-benzyl-d-glucofuranoside), antagonizes in vitro the smooth-muscle action of a large number of biogenic amines and polypeptides, the accelerated migration of leucocytes induced by endotoxin, and the Schultz-Dale phenomenon. In vivo, the compound shows anti-inflammatory and anti-allergic effects and improves the survival rate of infected mice treated with suboptimal doses of a sulphonamide.

Spezifische Wirkung einiger tierischer und bakterieller Polysaccharide auf Leucocytenin vitro

Different purified polysaccharides, mucopolysaccharides, phosphatides and carbohydrat-sulfonic acids have been investigated for their effect on stimulation of leucocytic migrationin vitro. The bacterial polysaccharides of proteus,S. marcescens, shiga and shiga fullantigen, have been found to be of high specific activity. All other compounds have much less or no activity. Therefore it might be concluded that the type of bacterial polysaccharides which promote leucocytic migration belong to a highly specific group.

Antagonistische Wirkung von Mucoprotein Gottschalk gegenüber Shearschem Polysaccharid an isolierten Zellen

Shears Polysaccharide and Gottschalks Virusreceptor-Mucoprotein are biological antagonists. The latter inhibits the stimulation of leucocytic migration produced by the former. Inhibition of virushaemagglutination by Gottschalks Mucoprotein is reversed by Shears Polysaccharide.

Wirkung von Harnextraktstoffen auf die Bewegungsreaktionen der Leukozyten

It could be demonstrated that extracts prepared from urine of pregnant women besides their gonadotropic activity contain also substances with an action on the migration of leucocytesin vitro. They have chemotactic effects and enhance the velocity of the migration of the leucocytes.

Über antimitotische und tumorhemmende Eigenschaften des inneren Salzes des 2,5-Bis-Äthylenimino-hydrochinons

A new hydroquinone compound, the internal salt of 2,5-bis-ethylenimino-hydroquinone, has a multiform antimitotic effect and a potent tumor-inhibiting action on a wide spectrum of inoculated tumors of mice and rats. On the other hand, normal tissues undergoing intensive cell division do not appear to be affected adversely from the histological standpoint.

Die Wirkung von Demecolceinamiden an Zellenin vitro

A series of demecolceinamids was examinedin vitro on chicken fibroblasts, leucocytes, and different bacteria. It was found that with increasing length of the side chain on ring C the antimitotic activity is decreasing while the antibacterial effect is increasing.

Leukocytenemigrationsförderung durch Antigen-Antikörper-Reaktionin vitro

Pronounced stimulation of leucocytic migration can be produced by addition of low concentrations of different anti-chicken anti-sera to chicken leucocytes migrating in corresponding plasma. The effective substance is present in the precipitate produced by precipitating anti-serum.

Zur Frage der Begleitstoffe in gonadotropen Hormonpräparaten

Substances obtained from urinary extracts were investigated for their inhibitory effect on virus hemagglutination (Hirst), and a comparison was made with the gonadotropic hormone activity of these substances. No clear-cut parallelity between these characteristics was demonstrable. An urinary extract substance was further tested both prior to and subsequent to contact with the virus receptor destroying enzyme (R.D.E.), for the three established properties, hormonal activity, leucocytotactic effect and influenza-virus-receptor characteristics. R.D.E. did not affect these three properties to the same degree. These results support the assumption that urinary extracts represent a mixture of chemically closely related substances.

Leukozytenemigrationsfördernde Wirkung durch Leukozytenschädigung

Leukocytic cells after slight damage produce stimulation of migration of other normal leucocytes; normal leukocytes inhibit to some extent migration of other normal leukocytes, killed leukocytes have no effect. The significance of this result is, that secondary accumulation of leukocytes with not primary chemotactic substances may be explained by the interaction of damaged leukocytes.