F. Witte

[Biodegradable synthetic implant materials : clinical applications and immunological aspects].

ZusammenfassungBiodegradable synthetische Implantatmaterialien haben sich in den letzten Jahren in verschiedenen Anwendungsbereichen etabliert. Keramische Werkstoffe wie Kalziumphosphate und Biogläser sowie Polymere kommen als degradable Implantate zum Einsatz; zusätzlich werden sie inzwischen auch als Beschichtungsmaterialen oder Mikrosphären für die Pharmakonfreisetzung eingesetzt oder sie dienen als Matrix für das Tissue Engineering. Da beim Abbau dieser Materialien große Mengen an Abbauprodukten anfallen, beschäftigt sich dieser Review mit der Fragestellung, ob allergische Immunreaktionen, wie sie für klassische metallische oder auch organische Implantatmaterialien berichtet wurden, auch für degradable synthetische Biomaterialien in der Klinik eine Rolle spielen. Es werden weiterhin mögliche Erklärungsansätze entwickelt, um das Fehlen klinischer Fallberichte über Allergien auf degradable Implantatmaterialien zu erklären.AbstractIn the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.

Degradable synthetische Implantatmaterialien

ZusammenfassungBiodegradable synthetische Implantatmaterialien haben sich in den letzten Jahren in verschiedenen Anwendungsbereichen etabliert. Keramische Werkstoffe wie Kalziumphosphate und Biogläser sowie Polymere kommen als degradable Implantate zum Einsatz; zusätzlich werden sie inzwischen auch als Beschichtungsmaterialen oder Mikrosphären für die Pharmakonfreisetzung eingesetzt oder sie dienen als Matrix für das Tissue Engineering. Da beim Abbau dieser Materialien große Mengen an Abbauprodukten anfallen, beschäftigt sich dieser Review mit der Fragestellung, ob allergische Immunreaktionen, wie sie für klassische metallische oder auch organische Implantatmaterialien berichtet wurden, auch für degradable synthetische Biomaterialien in der Klinik eine Rolle spielen. Es werden weiterhin mögliche Erklärungsansätze entwickelt, um das Fehlen klinischer Fallberichte über Allergien auf degradable Implantatmaterialien zu erklären.AbstractIn the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.

Injizierbare Trägersysteme für die Wachstumsfaktorapplikation zur minimal-invasiven Knochenheilungsstimulation

The characterization and cloning of growth factors for bone healing provide an enormous potential for minimally invasive treatment procedures for bone defects or fractures. However, the clinical application of injection vehicles for these growth factors must be made user-friendlier. In this study, two different injection vehicles were tested for their practicability and efficacy to enhance callus maturation during distraction osteogenesis. Calcium phosphate carriers showed a rather low user-friendliness and were less efficient in the animal model of distraction osteogenesis in sheep. Collagen carriers provided both a higher practicability for injection procedures and a higher efficacy.

Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model

In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.ZusammenfassungIn dieser Studie werden die ersten Ergebnisse von unterschiedlichen an Titanzylindern gebundenen Polymeren vorgestellt. Diese wurden im Rahmen einer tierexperimentellen Studie an „New Zealand White Rabbits“ bezüglich ihrer Osteointegration untersucht. Hierbei konnte in den ersten qualitativen histologischen Analysen sowie in DEXA- und Mikro-CT-Messungen eine deutlich verbesserte Integration des Implantats im Knochen nachgewiesen werden.AbstractIn this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.

Injectable carrier system for growth factor application in minimally invasive stimulation of bone healing

The characterization and cloning of growth factors for bone healing provide an enormous potential for minimally invasive treatment procedures for bone defects or fractures. However, the clinical application of injection vehicles for these growth factors must be made user-friendlier. In this study, two different injection vehicles were tested for their practicability and efficacy to enhance callus maturation during distraction osteogenesis. Calcium phosphate carriers showed a rather low user-friendliness and were less efficient in the animal model of distraction osteogenesis in sheep. Collagen carriers provided both a higher practicability for injection procedures and a higher efficacy.

Degradable synthetische Implantatmaterialien@@@Biodegradable synthetic implant materials: Klinische Applikationen und immunologische Aspekte@@@Clinical applications and immunological aspects

ZusammenfassungBiodegradable synthetische Implantatmaterialien haben sich in den letzten Jahren in verschiedenen Anwendungsbereichen etabliert. Keramische Werkstoffe wie Kalziumphosphate und Biogläser sowie Polymere kommen als degradable Implantate zum Einsatz; zusätzlich werden sie inzwischen auch als Beschichtungsmaterialen oder Mikrosphären für die Pharmakonfreisetzung eingesetzt oder sie dienen als Matrix für das Tissue Engineering. Da beim Abbau dieser Materialien große Mengen an Abbauprodukten anfallen, beschäftigt sich dieser Review mit der Fragestellung, ob allergische Immunreaktionen, wie sie für klassische metallische oder auch organische Implantatmaterialien berichtet wurden, auch für degradable synthetische Biomaterialien in der Klinik eine Rolle spielen. Es werden weiterhin mögliche Erklärungsansätze entwickelt, um das Fehlen klinischer Fallberichte über Allergien auf degradable Implantatmaterialien zu erklären.AbstractIn the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.

Verbesserte Osteointegration von Titanimplantaten nach Oberflächenbeschichtung mit Polymeren im Kaninchenmodell

In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.ZusammenfassungIn dieser Studie werden die ersten Ergebnisse von unterschiedlichen an Titanzylindern gebundenen Polymeren vorgestellt. Diese wurden im Rahmen einer tierexperimentellen Studie an „New Zealand White Rabbits“ bezüglich ihrer Osteointegration untersucht. Hierbei konnte in den ersten qualitativen histologischen Analysen sowie in DEXA- und Mikro-CT-Messungen eine deutlich verbesserte Integration des Implantats im Knochen nachgewiesen werden.AbstractIn this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.

Verbesserte Osteointegration von Titanimplantaten nach Oberflächenbeschichtung mit Polymeren im Kaninchenmodell@@@Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model

In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.ZusammenfassungIn dieser Studie werden die ersten Ergebnisse von unterschiedlichen an Titanzylindern gebundenen Polymeren vorgestellt. Diese wurden im Rahmen einer tierexperimentellen Studie an „New Zealand White Rabbits“ bezüglich ihrer Osteointegration untersucht. Hierbei konnte in den ersten qualitativen histologischen Analysen sowie in DEXA- und Mikro-CT-Messungen eine deutlich verbesserte Integration des Implantats im Knochen nachgewiesen werden.AbstractIn this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.